Results 171 to 180 of about 137,024 (324)

Phase I/II Trial of Perioperative Avelumab in Combination With Chemoradiation in the Treatment of Stage II/III Resectable Esophageal and Gastroesophageal Junction Cancer

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.
Nataliya V. Uboha   +15 more
wiley   +1 more source

A new genomic resource to enable standardized surveys of SNPs across the native range of brook trout (Salvelinus fontinalis)

open access: yesMolecular Ecology Resources, EarlyView., 2023
Abstract Understanding how genetic diversity is distributed across spatiotemporal scales in species of conservation or management concern is critical for identifying large‐scale mechanisms affecting local conservation status and implementing large‐scale biodiversity monitoring programmes.
Nadya R. Mamoozadeh   +5 more
wiley   +1 more source

Microsatellite instability during the immortalization and transformation of human breast epithelial cells in vitro [PDF]

open access: bronze, 1999
Yajue Huang   +6 more
openalex   +1 more source

Trends in Immunotherapy (IO) Use and Survival Among Patients With High‐Incidence Stage IV Cancers Across the United States

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives IO has transformed cancer management, but its adoption in advanced cancer patients varies by tumor type. With more Stage IV patients undergoing surgery, understanding site‐specific outcomes in these challenging patients is essential.
Samantha C. Warwar   +4 more
wiley   +1 more source

Scaling‐up RADseq methods for large datasets of non‐invasive samples: Lessons for library construction and data preprocessing

open access: yesMolecular Ecology Resources, EarlyView., 2023
Abstract Genetic non‐invasive sampling (gNIS) is a critical tool for population genetics studies, supporting conservation efforts while imposing minimal impacts on wildlife. However, gNIS often presents variable levels of DNA degradation and non‐endogenous contamination, which can incur considerable processing costs. Furthermore, the use of restriction‐
Larissa S. Arantes   +6 more
wiley   +1 more source

CIMIL-CRC: a clinically-informed multiple instance learning framework for patient-level colorectal cancer molecular subtypes classification from H\&E stained images [PDF]

open access: yesarXiv
Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS) subtype. There is promising potential in utilizing deep neural networks (DNNs) to automate the differentiation of CRC ...
arxiv  

Fluorescence-Based Resource for Semiautomated Genomic Analyses Using Microsatellite Markers

open access: hybrid, 1994
Roy C. Levitt   +6 more
openalex   +1 more source

CT Scans Understage Lymph Nodes in Gastric and Gastroesophageal Adenocarcinoma

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives The presence of lymph node metastases in patients with gastric and gastroesophageal junction (GEJ) adenocarcinoma provides prognostic information and guides treatment decisions. We sought to determine the sensitivity of computed tomography (CT) imaging for clinical nodal staging in patients with resectable gastric and
Morgan F. Pettigrew   +6 more
wiley   +1 more source

Evolutionary history and seascape genomics of Harbour porpoises (Phocoena phocoena) across environmental gradients in the North Atlantic and adjacent waters

open access: yesMolecular Ecology Resources, EarlyView., 2023
Abstract The Harbour porpoise (Phocoena phocoena) is a highly mobile cetacean species primarily occurring in coastal and shelf waters across the Northern hemisphere. It inhabits heterogeneous seascapes broadly varying in salinity and temperature. Here, we produced 74 whole genomes at intermediate coverage to study Harbour porpoise's evolutionary ...
Enrique Celemín   +13 more
wiley   +1 more source

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