Results 31 to 40 of about 140,760 (298)

De Novo Assembly, Characterization and Functional Annotation of Southern Hake (Merluccius australis) Transcriptome

Frontiers in Marine Science, 2016
Southern hake (Merluccius australis) is an ecological and economically important demersal fish in Chile and Argentina. Notwithstanding, genetic resource for genetic or ecological studies on this species are scarce.
Daniela Reyes, John Gold, Ruth Gonzalez, Rodrigo Vidal   +3 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A Web-Based Prototype System for Deforestation Detection on High-Resolution Remote Sensing Imagery With Deep Learning

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Forests are the largest carbon storage and carbon sinks on land and are closely related to global climate change. Using remote sensing images to monitor global deforestation has become the mainstream method, mainly because of their long time-series ...
Zhipan Wang, Zewen Mo, Yinyu Liang, Zijun Yang, Xiang Liao, Zhongwu Wang, Qingling Zhang   +6 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The Population Structure of a Globe Artichoke Worldwide Collection, as Revealed by Molecular and Phenotypic Analyzes

Frontiers in Plant Science, 2022
The knowledge of the organization of the domesticated gene pool of crop species is an essential requirement to understand crop evolution, to rationalize conservation programs, and to support practical decisions in plant breeding.
Domenico Rau, Giovanna Attene, Monica Rodriguez, Limbo Baghino, Anna Barbara Pisanu, Davide Sanna, Alberto Acquadro, Ezio Portis, Cinzia Comino   +8 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Isolation and Characterization of Microsatellite Loci for the Large-Seeded Tree Protorhus deflexa (Anacardiaceae)

Applications in Plant Sciences, 2013
Premise of the study: Protorhus deflexa is an endemic large-seeded tree in Madagascar that depends heavily on insects for cross-pollination and on large-bodied frugivores for seed dispersal.
Hiroki Sato, Christopher Adenyo, Tsuyoshi Harata, Satoshi Nanami, Akira Itoh, Yukio Takahata, Miho Inoue-Murayama   +6 more
doaj   +1 more source

Effects of hunting on genetic diversity, inbreeding and dispersal in Finnish black grouse (Lyrurus tetrix)

Evolutionary Applications, 2023
Intensive hunting activities such as commercial fishing and trophy hunting can have profound influences on natural populations. However, less intensive recreational hunting can also have subtle effects on animal behaviour, habitat use and movement, with ...
Rebecca S. Chen, Carl D. Soulsbury, Christophe Lebigre, Gilbert Ludwig, Kees vanOers, Joseph I. Hoffman   +5 more
doaj   +1 more source

Genomic Comparison and Genetic Marker Identification of the White-Spotted Bamboo Shark Chiloscyllium plagiosum

Frontiers in Marine Science, 2022
The white-spotted bamboo shark (Chiloscyllium plagiosum) is an ecologically and commercially important marine cartilaginous fish in the Indo-Western Pacific.
Ruirui Zhao, Shanshan Cai, Dingfang Lu, Pengfei Li, Shengyong Xu, Yuan Li   +5 more
doaj   +1 more source

Estimation of population differentiation using pedigree and molecular data in Black Slavonian pig [PDF]

Acta Fytotechnica et Zootechnica, 2020
The aim of the study was to investigate the genetic differentiation of the Black Slavonian pig population. Two parallel analyses were performed using genealogical records and molecular data. Pedigree information of 6,099 pigs of the Black Slavonian breed
Kristina Gvozdanović
doaj   +1 more source