Results 31 to 40 of about 364,495 (312)

Demystified ...: Microsatellites [PDF]

Molecular Pathology, 2000
Microsatellite DNA sequences consist of relatively short repeats of one to five base pair units; together with satellites and minisatellites they comprise a larger family known as tandemly repetitive sequences. Microsatellites are found both in prokaryotes and eukaryotes, including humans, wherein they appear scattered almost at random throughout the ...
openaire   +2 more sources

FDA Approval Summary: Pembrolizumab for the Treatment of Microsatellite Instability-High Solid Tumors

Clinical Cancer Research, 2019
The FDA approved pembrolizumab on May 23, 2017, for the treatment of adult and pediatric patients with unresectable or metastatic, microsatellite instability-high (MSI-H), or mismatch repair deficient (dMMR) solid tumors that have progressed following ...
L. Marcus, S. Lemery, P. Keegan, R. Pazdur   +3 more
semanticscholar   +1 more source

Mendelian Inheritance Pattern and High Mutation Rates of Microsatellite Alleles in the Diatom Pseudo-nitzchia multistriata [PDF]

, 2012
The diatom Pseudo-nitzschia multistriata exhibits a diplontic life cycle composed of an extensive phase of vegetative cell division and a brief phase of sexual reproduction.
Amos, Bengtsson, Brinkmann, Callen, Casteleyn, Chepurnov, Chepurnov, Christophe Legrand, Cloutier, Cock van Oosterhout, De Meester, Dobrowolski, Douhovnikoff, Duret, D’Alelio, D’Alelio, D’Alelio, Ellegren, Ellegren, Ellegren, Evans, Gabriele Procaccini, Guillard, Halkett, Hohoff, Härnström, Kruglyak, Lakeman, Li, Marina Montresor, Ouborg, O’Connell, Reece, Reusch, Round, Rynearson, Rynearson, Rynearson, Schurko, Selkoe, Seyfert, Spurgin, Sylvie V.M. Tesson, Tesson, Valière, van Oosterhout, van Oosterhout, Vanoverbeke, White, Wiebe H.C.F. Kooistra, Zar   +50 more
core   +1 more source

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

JAMA Oncology, 2019
Importance The anti–programmed cell death protein 1 (PD-1) antibody pembrolizumab is approved by the US Food and Drug Administration for the treatment of microsatellite instability–high (MSI-H) or mismatch repair–deficient (dMMR) solid tumors, but the ...
W. Abida, M. Cheng, J. Armenia, S. Middha, K. Autio, H. Vargas, D. Rathkopf, M. Morris, D. Danila, S. Slovin, E. Carbone, E. Barnett, Melanie A. Hullings, J. Hechtman, A. Zehir, J. Shia, P. Jonsson, Z. Stadler, P. Srinivasan, V. Laudone, V. Reuter, J. Wolchok, N. Socci, B. Taylor, M. Berger, P. Kantoff, C. Sawyers, N. Schultz, D. Solit, A. Gopalan, H. Scher   +30 more
semanticscholar   +1 more source

ICEYE microsatellite SAR constellation status update: Evaluation of first commercial imaging modes [PDF]

arXiv, 2021
The ICEYE constellation features the first operational microsatellite based X-band SAR sensors suitable for all weather day-and-night Earth Observation. In this paper, we report on the status of the ICEYE Constellation and describe the characteristics of the first operational imaging modes.
arxiv  

Natural recovery of genetic diversity by gene flow in reforested areas of the endemic Canary Island pine, Pinus canariensis [PDF]

Forest Ecology and Management 244, 1-3 (2007) 122-128, 2008
The endemic pine, Pinus canariensis, forms one of the main forest ecosystems in the Canary Islands. In this archipelago, pine forest is a mosaic of natural stands (remnants of past forest overexploitation) and artificial stands planted from the 1940's. The genetic makeup of the artificially regenerated forest is of some concern. The use of reproductive
arxiv   +1 more source

Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium [PDF]

, 2015
© 2015 Webster et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in ...
A. A. Hamidou, A. Garba, A. Gouvras, A. M. Emery, AM Emery, B. L. Webster, BL Webster, C Van Oosterhout, CM Gower, CM Gower, D. Rollinson, F. Allan, J. P. Webster, JP Webster, K. A. Mohammed, L Meurs, M Kearse, M. Rabone, R Peakall, S Knopp, S. Knopp, S. M. Ame, T. Pennance, TC Glenn   +23 more
core   +4 more sources

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Journal of Hematology & Oncology, 2019
Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li   +3 more
semanticscholar   +1 more source

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.

Journal of Clinical Oncology, 2019
PURPOSE Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and endometrial cancer (EC) to screen for Lynch syndrome (LS)-associated cancer predisposition ...
Alicia J Latham, P. Srinivasan, Y. Kemel, J. Shia, C. Bandlamudi, D. Mandelker, S. Middha, J. Hechtman, A. Zehir, Marianne E. Dubard-Gault, Christina Tran, Carolyn Stewart, M. Sheehan, A. Penson, D. DeLair, R. Yaeger, J. Vijai, Semanti Mukherjee, Jesse Galle, M. Dickson, Y. Janjigian, E. O’Reilly, N. Segal, L. Saltz, D. Reidy‐Lagunes, A. Varghese, D. Bajorin, M. Carlo, K. Cadoo, M. Walsh, M. Weiser, J. G. Aguilar, D. Klimstra, L. Diaz, J. Baselga, Liying Zhang, M. Ladanyi, D. Hyman, D. Solit, M. Robson, B. Taylor, K. Offit, M. Berger, Z. Stadler   +43 more
semanticscholar   +1 more source

Microsatellite Instability in Keratoacanthoma [PDF]

Cancer, 1995
Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In general, this form of genomic instability results from mutations that inactivate DNA mismatch repair genes.
Stephen N. Thibodeau, Mark R. Pittelkow, Kevin C. Hailing M.D., Ronald Honchel   +3 more
openaire   +3 more sources