Results 81 to 90 of about 299,272 (340)

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Natural hybridization between Populus nigra L. and P. x canadensis Moench. Hybrid offspring competes for niches along the Rhine river in the Netherlands [PDF]

, 2008
Black poplar (Populus nigra L.) is a major species for European riparian forests but its abundance has decreased over the decades due to human influences.
Arens, P.F.P., Beringen, R., Schoot, J., van der, Smulders, M.J.M., Vanden Broeck, A., Volosyanchuk, R., Vosman, B.   +6 more
core   +2 more sources

Identification of Novel Microsatellite Markers Flanking the SMN1 and SMN2 Duplicated Region and Inclusion Into a Single-Tube Tridecaplex Panel for Haplotype-Based Preimplantation Genetic Testing of Spinal Muscular Atrophy

Frontiers in Genetics, 2019
Preimplantation genetic testing for the monogenic disorder (PGT-M) spinal muscular atrophy (SMA) is significantly improved by supplementation of SMN1 deletion detection with marker-based linkage analysis. To expand the availability of informative markers
Mingjue Zhao, Mulias Lian, Felicia S.H. Cheah, Arnold S.C. Tan, Arnold S.C. Tan, Anupriya Agarwal, Samuel S. Chong, Samuel S. Chong, Samuel S. Chong   +8 more
doaj   +1 more source

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self‐Supervised Learning

Advanced Science, EarlyView.
CRCFound is a self‐supervised learning‐based CT image foundation model for colorectal cancer (CRC). Pretrained on 5137 unlabeled CRC CT images, it learns universal feature representations, enabling efficient adaptation to various clinical tasks. The model demonstrates outstanding performance and generalization across multiple diagnostic and prognosis ...
Jing Yang, Du Cai, Junwei Liu, Zhenfeng Zhuang, Yibin Zhao, Feng‐ao Wang, Chenghang Li, Chuling Hu, Baowen Gai, Yiping Chen, Yixue Li, Liansheng Wang, Feng Gao, Xiaojian Wu   +13 more
wiley   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Ten polymorphic microsatellite primers in the tropical tree caimito, Chrysophyllum cainito (Sapotaceae). [PDF]

, 2014
UnlabelledPremise of the studyWe developed microsatellite primers for the tropical tree Chrysophyllum cainito (Sapotaceae) to determine the native range of the species, investigate the origin of cultivated populations, and examine the partitioning of ...
Parker, Ingrid M, Petersen, Jennifer J, Potter, Daniel   +2 more
core   +3 more sources

A Comparison of Microsatellites in Phytopathogenic Aspergillus Species in Order to Develop Markers for the Assessment of Genetic Diversity among Its Isolates

Frontiers in Microbiology, 2017
The occurrence of Microsatellites (SSRs) has been witnessed in most of the fungal genomes however its abundance varies across species. In the present study, we analyzed the frequency of SSRs in the whole genome and transcripts of two phyto-pathogenic ...
Sahil Mahfooz, Satyendra P. Singh, Nishtha Mishra, Aradhana Mishra   +3 more
doaj   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

The geographic distribution of saccharomyces cerevisiae isolates within three Italian neighboring winemaking regions reveals strong differences in yeast abundance, genetic diversity and industrial strain dissemination [PDF]

, 2017
In recent years the interest for natural fermentations has been re-evaluated in terms of increasing the wine terroir and managing more sustainable winemaking practices.
Almeida, Antonangelo, Berger, Borneman, Bovo, Bovo, Bovo, Bruvo, Capece, Coi, Comi, Cordero-Bueso, Cubillos, De Filippo, Di Maio, Diezmann, Erny, Esteve-Zarzoso, Ezov, Fay, Franco-Duarte, Gao, Gayevskiy, Gayevskiy, Huson, Hyma, Johnson, Kamvar, Knight, Kumar, Legras, Legras, Legras, Liti, Lopez, Magwene, Martini, Martiniuk, Mortimer, Nardi, Naumov, Novo, Perez, Querol, Querol, Richards, Robiglio, Ruderfer, Sampaio, Santamaría, Schacherer, Schuller, Schuller, Sipiczki, Sniegowski, Stefanini, Tapsoba, Treu, Valero, Valero, Wang, Weir, Wright, Zhang   +63 more
core   +3 more sources

Development and Characterization of Microsatellite Loci for the Moroccan Endemic Endangered Species Argania spinosa (Sapotaceae)

Applications in Plant Sciences, 2014
Premise of the study: Microsatellite loci were developed for the Moroccan endemic endangered species Argania spinosa with a combination of a typical library enrichment procedure and a 454 GS FLX Titanium–based high-throughput sequencing approach ...
Yasmina El Bahloul, Nicolas Dauchot, Ikrame Machtoun, Fatima Gaboun, Pierre Van Cutsem   +4 more
doaj   +1 more source