Results 91 to 100 of about 859,289 (399)
Deep Learning based Prediction of MSI using MMR Markers in Colorectal Cancer [PDF]
arXiv, 2022 The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate treatment selection, has prognostic implications and is used to investigate the possibility of patients having ...
arxiv
An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins. [PDF]
, 2013 Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E.
Donnenberg, Michael S. +2 more
core +1 more source
Microsatellite Instability in Endometrial Carcinoma.
Annals of Pathology and Laboratory Medicine, 2020 Background: Endometrial carcinoma is the commonest gynaecological malignancy in the western countries with a standardised incidence of 8 per 100000 women. In India and Southeast Asia, the incidence of endometrial carcinoma is low but it is increasing due
S. Toor +3 more
semanticscholar +1 more source
Tumor Biology, 2017 This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability.
Britta Kleist +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Gut Pathogens, 2020 Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP).
Yoshiki Okita +14 more
doaj +1 more source
Local Attention Graph-based Transformer for Multi-target Genetic Alteration Prediction [PDF]
arXiv, 2022 Classical multiple instance learning (MIL) methods are often based on the identical and independent distributed assumption between instances, hence neglecting the potentially rich contextual information beyond individual entities. On the other hand, Transformers with global self-attention modules have been proposed to model the interdependencies among ...
arxiv
Landscape of Microsatellite Instability Across 39 Cancer Types.
JCO Precision Oncology, 2017 Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic microsatellites and is caused by defects in the mismatch repair system. Mismatch repair deficiency that leads to MSI has been well described in several types of
Russell Bonneville +8 more
semanticscholar +1 more source
Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability
Cancers, 2020 Simple Summary Microsatellite instability (MSI) has been detected in multiple types of gynecologic cancers. MSI is linked to mutations in mismatch repair (MMR) genes that cause mismatch repair deficit (dMMR) in human cells.
Madhura Deshpande +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto +3 more
wiley +1 more source