Results 91 to 100 of about 55,423 (289)

Targeted Cancer Next-Generation Sequencing as a Primary Screening Tool for Microsatellite Instability and Lynch Syndrome in Upper Gastrointestinal Tract Cancers [PDF]

, 2019
Alexander G. Christakis, David Papke, Jonathan A. Nowak, Matthew B. Yurgelun, Agoston T. Agoston, Neal I. Lindeman, Laura E. MacConaill, Lynette M. Sholl, Fei Dong   +8 more
openalex   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers [PDF]

, 2023
Javier Ros, Iosune Baraibar, N. Saoudi Gonzalez, Marta Rodríguez, Francesc Salvà, Josep Tabernero, Élena Elez   +6 more
openalex   +1 more source

Microsatellite Instability in Malignant Melanomas

Acta Dermato-Venereologica, 2001
Microsatellite instability (MSI) is caused by deficient DNA mismatch repair, and results in a "mutator" phenotype. Recent studies have produced contradictory results about the frequency and significance of MSI in malignant melanomas. In this study, we therefore determined the time of onset and relative frequency of MSI during the progression of ...
M M, Kroiss, T M, Vogt, J, Schlegel, M, Landthaler, W, Stolz   +4 more
openaire   +3 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Microsatellite instability as an expert biomarker in cancer diseases

Journal of Education, Health and Sport
The diagnostic and predictive activities of the oncology service are based on a wide range of immunohistochemical and genetic studies with a different spectrum of applications and different levels of efficacy.
O. Bondar
doaj   +1 more source

Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions [PDF]

, 2020
Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi, Hiromasa Ohira   +15 more
openalex   +1 more source

Biomarker‐based long‐term safety and efficacy of PD‐1/PD‐L1 inhibitors combined with chemotherapy in advanced gastroesophageal carcinomas: A systematic review and meta‐analysis

Precision Medical Sciences, EarlyView.
This graphical abstract concisely encapsulates the principal findings of the meta‐analysis, emphasizing the notable survival advantages of PD‐1/PD‐L1 inhibitors in conjunction with chemotherapy for advanced gastroesophageal tumors. The visual presentation briefly defines the study's history, methodologies, results, and conclusions, while highlighting ...
Muhammad Ahsan, Muhammad Javaid Umer, Rath Shree, Jan Qureshi Ahmar, Ahmad Khan Mudassir, Masood Salman, Muhammad Hassan, Hayyat Omna, Iqbal Javed, Asraf Hussain   +9 more
wiley   +1 more source

IMMU-26. DISEASE CONTROL IN A PEDIATRIC PATIENT WITH NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM) AND SOMATIC HIGH MICROSATELLITE INSTABILITY (MSI-H) WITH PD-1 INHIBITOR NIVOLUMAB (NIVO) ONLY AND NO FOCAL RADIOTHERAPY (RT) [PDF]

, 2020
Trisha Larkin, Jason E. Blatt, Sridharan Gururangan   +2 more
openalex   +1 more source

Microsatellite instability in colorectal cancer

British Journal of Surgery, 2006
Abstract Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although the basic mechanisms are not clear, there is increased understanding of the clinicopathological consequences of MSI.
K, Söreide, E A M, Janssen, H, Söiland, H, Körner, J P A, Baak   +4 more
openaire   +2 more sources