Results 131 to 140 of about 868,914 (412)
Advanced Science, EarlyView.Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu +10 more
wiley +1 more source
Medical Journal of The Islamic Republic of Iran, 2009 Background:The polymorphic variants at codon 72 of the p53 gene, encoding either proline or arginine at residue 72,produce marked change in the structure of p53.From the evidence that the DNAmismatch repair system and p53 interact to maintain genomic ...
Mansour Salehi +3 more
doaj
Genetics and Molecular Biology, 2006 The structurally complex MYCL1 microsatellite marker is often used to determine microsatellite instability in colorectal cancers but the allelic variation of this marker has remained largely uncharacterized in both populations and in cancers.
Hanna Vauhkonen, Antti Sajantila
doaj +1 more source
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. [PDF]
PLoS ONE, 2007 Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently.
Marcos R H Estécio +11 more
doaj +1 more source
Microsatellite Instability and Colorectal Cancer Prognosis [PDF]
Clinical Cancer Research, 2005 Abstract Purpose: Many studies have evaluated the role of high levels of microsatellite instability (MSI) as a prognostic marker and predictor of the response to chemotherapy in colorectal cancer (CRC); however, the results are not conclusive.
BENATTI, Piero +19 more
openaire +6 more sources
Advanced Science, EarlyView.This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng +10 more
wiley +1 more source
The Importance of DNA Repair in Tumor Suppression [PDF]
, 2004 The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions. One hallmark of cancerous genomes is genomic instability, with mutation rates far greater than those of normal cells.
arxiv +1 more source
Self supervised learning improves dMMR/MSI detection from histology slides across multiple cancers [PDF]
Proceedings of the MICCAI Workshop on Computational Pathology,
156, 2021, 191-205, 2021 Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors directly from H&E stained slides have shown promise in improving diagnosis of MSI patients.
arxiv
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
Journal of Clinical Oncology, 2019 PURPOSE In the CLASSIC and MAGIC trials, microsatellite instability (MSI)-high status was a favorable prognostic and potential negative predictive factor for neoadjuvant/adjuvant chemotherapy in resectable gastric cancer (GC). Given the low prevalence of
F. Pietrantonio +23 more
semanticscholar +1 more source