Results 181 to 190 of about 859,289 (399)

Prognosis of mucinous colon cancer is determined by histological biomarkers rather than microsatellite instability

Histopathology, Volume 82, Issue 2, Page 314-323, January 2023., 2023
The prognostic value of microsatellite instability (MSI), as well as other histological characteristics such as lymphovascular invasion (LI), perineural invasion (PNI) and extramural vascular invasion (EMVI), is unclear in colorectal mucinous carcinoma (MC).
Peter H. van Zwam, Elisa M. Vink‐Börger, Carolien M. Bronkhorst, Adriaan P. de Bruine, Anneke A. van der Wurff, Harm J.T. Rutten, Valery E.P.P. Lemmens, Iris D. Nagtegaal, Niek Hugen   +8 more
wiley   +1 more source

Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches

Cellular and Molecular Life Sciences, 2018
Gastric cancer is one of the most aggressive malignancies, with limited treatment options in both locally advanced and metastatic setting, resulting in poor prognosis.
M. Ratti, A. Lampis, J. Hahne, R. Passalacqua, N. Valeri   +4 more
semanticscholar   +1 more source

Single‐cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer

Immunology, Volume 168, Issue 1, Page 135-151, January 2023., 2023
Our study provides deep insights into infiltrating B cells, including their phenotypes, location, antibody isotypes and interplay within the TME. Moreover, it was found that a B cell‐rich group, which was characterized by microsatellite instability‐high (MSI‐H) and high tumour mutation burden (TMB‐H), as well as immunosuppressive property in particular,
Jie Xia, Zhangjuan Xie, Gengming Niu, Zhou Lu, Zhiqiang Wang, Yun Xing, Jun Ren, Zhiqing Hu, Runqi Hong, ZhiPeng Cao, Shanliang Han, Yiwei Chu, Ronghua Liu, Chongwei Ke   +13 more
wiley   +1 more source

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj  

Correlations between microsatellite instability and the biological behaviour of tumours

Journal of Cancer Research and Clinical Oncology, 2019
Microsatellites are widely distributed repetitive DNA motifs, accounting for approximately 3% of the genome. Due to mismatch repair system deficiency, insertion or deletion of repetitive units often occurs, leading to microsatellite instability.
Guang Yang, Ruizhu Zheng, Zai-shun Jin
semanticscholar   +1 more source

Genetic structure and historic demography of endangered unarmoured threespine stickleback at southern latitudes signals a potential new management approach

Molecular Ecology, Volume 31, Issue 24, Page 6515-6530, December 2022., 2022
Abstract Habitat loss, flood control infrastructure, and drought have left most of southern California and northern Baja California's native freshwater fish near extinction, including the endangered unarmoured threespine stickleback (Gasterosteus aculeatus williamsoni). This subspecies, an unusual morph lacking the typical lateral bony plates of the G.
Rachel Turba, Jonathan Q. Richmond, Sorel Fitz‐Gibbon, Marco Morselli, Robert N. Fisher, Camm C. Swift, Gorgonio Ruiz‐Campos, Adam R. Backlin, Chris Dellith, David K. Jacobs   +9 more
wiley   +1 more source

Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia

Gastroenterology Research and Practice, 2012
Background. In gastric carcinogenesis, changes of DNA methylation appear to be an early molecular event, and the genome-wide methylation state is closely correlated with the level of long interspersed nucleotide element-1 (LINE-1) methylation.
Jin Su Kim, Woo Chul Chung, Kang-Moon Lee, Chang Nyol Paik, Kyeong Soo Lee, Hye Ji Kim, Young Wook Kim, Ji Han Jung, Seung June Noh, Yun Kyung Lee   +9 more
doaj   +1 more source

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

bioRxiv, 2019
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific ...
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, C. Schwarz, Katharina Ehrenhöfer-Wölfer, A. Schlattl, Andreas Wernitznig, J. Lipp, Kota Nagasaka, Petra van der Lelij, G. Bader, M. Koi, A. Goel, Ralph A. Neumüller, J. Peters, N. Kraut, M. Pearson, M. Petronczki, Simon Wöhrle   +19 more
semanticscholar   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes. [PDF]

, 2019
BackgroundThe major histocompatibility complex class I (MHC-I) molecule is a protein complex that displays intracellular peptides to T cells, allowing the immune system to recognize and destroy infected or cancerous cells.
Carter, Hannah, Castro, Andrea, Ozturk, Kivilcim, Pyke, Rachel Marty, Xian, Su, Zanetti, Maurizio   +5 more
core   +1 more source