Results 11 to 20 of about 55,423 (289)

Editorial: Microsatellite and microsatellite instability

Frontiers in Genetics, 2023
Alexandre How-Kit, Kai Ye, Kai Ye, Kai Ye, Kai Ye, Kai Ye   +5 more
openaire   +4 more sources

Clinical and morphological portrait of tumors with microsatellite instability

Успехи молекулярной онкологии, 2021
Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability.
A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

Dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer

IJU Case Reports, 2022
Introduction Prostate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been ...
Takumi Kageyama, Norihito Soga, Sho Sekito, Seiichi Kato, Yuji Ogura, Takahiro Kojima, Masahiro Kanai, Takahiro Inoue   +7 more
doaj   +1 more source

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Libri Oncologici, 2023
Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols.
Suzana Janković, Snježana Ramić, Tomislav Kelava, Zvonimir Misir, Iva Kirac, Goran Glavčić, Jakša Filipović-Čugura   +6 more
doaj   +1 more source

Long response duration to pembrolizumab in metastatic, castration-resistant prostate cancer with microsatellite instability-high and neuroendocrine differentiation: A case report

Frontiers in Oncology, 2022
BackgroundThe detection of microsatellite instability in urologic cancers is rare, especially in metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.Case presentationThis is a case of a 66-year-old Asian male patient with
Tsukasa Yoshida, Hiroshi Yaegashi, Ren Toriumi, Suguru Kadomoto, Hiroaki Iwamoto, Kouji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Atsushi Mizokami   +8 more
doaj   +1 more source

An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

Biology Direct, 2022
Background Historically, the molecular classification of colorectal cancer (CRC) was based on the global genomic status, which identified microsatellite instability in mismatch repair (MMR) deficient CRC, and chromosomal instability in MMR proficient CRC.
Pasquale Sibilio, Francesca Belardinilli, Valerio Licursi, Paola Paci, Giuseppe Giannini   +4 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity

iScience, 2023
Summary: There is an urgent need for markers to predict the efficacy of different chemotherapy drugs. Herein, we examined whether microsatellite instability (MSI) status can predict tumor multidrug sensitivity and explored the underlying mechanisms.
Taojun Ye, Anqi Lin, Zhengang Qiu, Shulu Hu, Chaozheng Zhou, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo   +8 more
doaj   +1 more source

Microsatellite Instability and Its Clinical Significance in Endometrial Carcinoma [PDF]

Zhongguo quanke yixue, 2022
BackgroundThe role of microsatellite instability in the progression of endometrial cancer, a common cancer in women, has obtained increasing attentions in recent years.
XIAO Jing, WU Ying
doaj   +1 more source

Pembrolizumab for a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high

IJU Case Reports, 2020
Introduction We report the case of a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high who was treated with pembrolizumab after cabazitaxel administration.
Motohiro Fujiwara, Yoshinobu Komai, Takeshi Yuasa, Noboru Numao, Shinya Yamamoto, Iwao Fukui, Junji Yonese   +6 more
doaj   +1 more source