Results 11 to 20 of about 124,795 (370)

Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin's Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. [PDF]

, 2015
Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers.
Alfieri, R, Amadori, Alberto, Boldrin, E, Cagol, M, Cappellesso, Rocco, Castoro, C, Chiarion Sileni, V, Fassan, Matteo, Rugge, Massimo, Rumiato, E, Ruol, A, Saggioro, D.   +11 more
core   +23 more sources

COLORECTAL CANCER: HISTOPATHOLOGICAL PROFILE AND PREVALENCE OF DNA REPAIR SYSTEM DEFICIENCY IN PATIENTS SUBMITTED TO SURGICAL TREATMENT IN A UNIVERSITY HOSPITAL [PDF]

ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2023
BACKGROUND: Part of colorectal cancer cases occurs due to modifications in the DNA mismatch repair system, which are responsible for microsatellite instability. This alteration results in an unconventional phenotypic pattern of colorectal cancer.
Julia Werner de Oliveira, Raquel Aguirra de Moraes, Samya Hamad Mehanna, Julia Costa Linhares   +3 more
doaj   +1 more source

Clinical and morphological portrait of tumors with microsatellite instability

Успехи молекулярной онкологии, 2021
Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability.
A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

Microsatellite instability in colorectal cancer [PDF]

Asia-Pacific Journal of Clinical Oncology, 2010
AbstractApproximately 20 percent of right‐sided colon cancers and 5 percent of left‐sided colon and rectal cancers have a deficient DNA mismatch repair system. This results in the widespread accumulation of mutations to nucleotide repeats, some of which occur within the coding regions of cancer‐related genes such as TGFβRII and BAX.
Iacopetta, Barry, Grieu, Fabienne, Amanuel, Benhur   +2 more
openaire   +7 more sources

Microsatellite Instability in Keratoacanthoma [PDF]

Cancer, 1995
Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In general, this form of genomic instability results from mutations that inactivate DNA mismatch repair genes.
Stephen N. Thibodeau, Mark R. Pittelkow, Kevin C. Hailing M.D., Ronald Honchel   +3 more
openaire   +3 more sources

Microsatellite instability in sarcomas [PDF]

Annals of Surgical Oncology, 1998
Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas.We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p--all potential regions of interest regarding musculoskeletal sarcomas ...
Stephanie S. Martin, Herbert S. Schwartz, Lora K. Hedges, W. Grear Hurt, Merlin G. Butler   +4 more
openaire   +3 more sources

Dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer

IJU Case Reports, 2022
Introduction Prostate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been ...
Takumi Kageyama, Norihito Soga, Sho Sekito, Seiichi Kato, Yuji Ogura, Takahiro Kojima, Masahiro Kanai, Takahiro Inoue   +7 more
doaj   +1 more source

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Libri Oncologici, 2023
Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols.
Suzana Janković, Snježana Ramić, Tomislav Kelava, Zvonimir Misir, Iva Kirac, Goran Glavčić, Jakša Filipović-Čugura   +6 more
doaj   +1 more source

Long response duration to pembrolizumab in metastatic, castration-resistant prostate cancer with microsatellite instability-high and neuroendocrine differentiation: A case report

Frontiers in Oncology, 2022
BackgroundThe detection of microsatellite instability in urologic cancers is rare, especially in metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.Case presentationThis is a case of a 66-year-old Asian male patient with
Tsukasa Yoshida, Hiroshi Yaegashi, Ren Toriumi, Suguru Kadomoto, Hiroaki Iwamoto, Kouji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Atsushi Mizokami   +8 more
doaj   +1 more source

Microsatellite instability in colorectal cancer [PDF]

Radiology and Oncology, 2011
Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis ...
Horvat, Matej, Štabuc, Borut
openaire   +4 more sources