Results 11 to 20 of about 91,099 (324)

Microsatellite Instability in Keratoacanthoma [PDF]

Cancer, 1995
Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In general, this form of genomic instability results from mutations that inactivate DNA mismatch repair genes.
Stephen N. Thibodeau, Mark R. Pittelkow, Kevin C. Hailing M.D., Ronald Honchel   +3 more
openaire   +3 more sources

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +4 more sources

Microsatellite instability in sarcomas [PDF]

Annals of Surgical Oncology, 1998
Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas.We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p--all potential regions of interest regarding musculoskeletal sarcomas ...
Stephanie S. Martin, Herbert S. Schwartz, Lora K. Hedges, W. Grear Hurt, Merlin G. Butler   +4 more
openaire   +3 more sources

Dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer

IJU Case Reports, 2022
Introduction Prostate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been ...
Takumi Kageyama, Norihito Soga, Sho Sekito, Seiichi Kato, Yuji Ogura, Takahiro Kojima, Masahiro Kanai, Takahiro Inoue   +7 more
doaj   +1 more source

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Libri Oncologici, 2023
Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols.
Suzana Janković, Snježana Ramić, Tomislav Kelava, Zvonimir Misir, Iva Kirac, Goran Glavčić, Jakša Filipović-Čugura   +6 more
doaj   +1 more source

Long response duration to pembrolizumab in metastatic, castration-resistant prostate cancer with microsatellite instability-high and neuroendocrine differentiation: A case report

Frontiers in Oncology, 2022
BackgroundThe detection of microsatellite instability in urologic cancers is rare, especially in metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.Case presentationThis is a case of a 66-year-old Asian male patient with
Tsukasa Yoshida, Hiroshi Yaegashi, Ren Toriumi, Suguru Kadomoto, Hiroaki Iwamoto, Kouji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Atsushi Mizokami   +8 more
doaj   +1 more source

Microsatellite instability in colorectal cancer [PDF]

Radiology and Oncology, 2011
Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis ...
Horvat, Matej, Štabuc, Borut
openaire   +4 more sources

An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

Biology Direct, 2022
Background Historically, the molecular classification of colorectal cancer (CRC) was based on the global genomic status, which identified microsatellite instability in mismatch repair (MMR) deficient CRC, and chromosomal instability in MMR proficient CRC.
Pasquale Sibilio, Francesca Belardinilli, Valerio Licursi, Paola Paci, Giuseppe Giannini   +4 more
doaj   +1 more source

Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity

iScience, 2023
Summary: There is an urgent need for markers to predict the efficacy of different chemotherapy drugs. Herein, we examined whether microsatellite instability (MSI) status can predict tumor multidrug sensitivity and explored the underlying mechanisms.
Taojun Ye, Anqi Lin, Zhengang Qiu, Shulu Hu, Chaozheng Zhou, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo   +8 more
doaj   +1 more source

Microsatellite Instability and Its Clinical Significance in Endometrial Carcinoma [PDF]

Zhongguo quanke yixue, 2022
BackgroundThe role of microsatellite instability in the progression of endometrial cancer, a common cancer in women, has obtained increasing attentions in recent years.
XIAO Jing, WU Ying
doaj   +1 more source