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Microsatellite Instability in Colorectal Cancer [PDF]
, 2016 Cancer is a genetic disease. Cancer cells contain various mutations, which includes SNPs to chromosomal aberrations. Together, these changes are referred to as genome instability.
Alanazi, Mohammad Saud +2 more
core +5 more sources
Microsatellite instability in ovarian neoplasms. [PDF]
British Journal of Cancer, 1995 Microsatellite instability has been observed in a variety of sporadic malignancies, but its existence in sporadic ovarian cancer has been the subject of conflicting reports.
Carcangiu, M. L. +6 more
core +7 more sources
Microsatellite Instability in Malignant Melanoma [PDF]
Cancer Genetics and Cytogenetics, 1998 Defective mismatch repair has been detected in human colorectal and endometrial carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to search for MIN in melanoma. Paraffin-embedded neoplastic and non-neoplastic control cells were obtained from 20 untreated individuals with cutaneous malignant melanoma.
Vishwas R. Talwalkar +4 more
openalex +4 more sources
Microsatellite instability in sacral chordoma [PDF]
Journal of Surgical Oncology, 2000 Microsatellite instability (MIN) is an indirect marker of globally defective DNA mismatch repair in the neoplastic cells of cancer patients. Chordomas are rare, primary skeletal malignancies for which few characteristic molecular genetic markers have been identified.
Lance Klingler +5 more
openalex +4 more sources
Microsatellite instability in colorectal cancer [PDF]
Asia-Pacific Journal of Clinical Oncology, 2010 AbstractApproximately 20 percent of right‐sided colon cancers and 5 percent of left‐sided colon and rectal cancers have a deficient DNA mismatch repair system. This results in the widespread accumulation of mutations to nucleotide repeats, some of which occur within the coding regions of cancer‐related genes such as TGFβRII and BAX.
Iacopetta, Barry +2 more
openaire +7 more sources
Microsatellite instability in multiple colorectal tumors [PDF]
International Journal of Cancer, 1999 Tumor multiplicity is a hallmark of hereditary cancers: in the colon-rectum multiple tumors represent 5-10% of all colorectal cancer cases. A portion of these cases belongs to hereditary non-polyposis colorectal cancer (HNPCC), a genetic cancer syndrome due to mismatch repair (MMR) gene mutations, phenotypically expressed as microsatellite instability (
Monica Pedroni +15 more
openalex +6 more sources
Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer.
New England Journal of Medicine, 2020 BACKGROUND Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) tumors after previous therapy.
T. André +20 more
semanticscholar +1 more source
Cancer Discovery, 2021 Sequence alterations in microsatellites and an elevated mutational burden are observed in 20% of gastric cancers (GC) and associated with clinical response to anti-programmed death (PD)-1 antibodies. However, 50% of microsatellite instability-high (MSI-H)
M. Kwon +16 more
semanticscholar +1 more source
Microsatellite Instability in Keratoacanthoma [PDF]
Cancer, 1995 Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In general, this form of genomic instability results from mutations that inactivate DNA mismatch repair genes.
Stephen N. Thibodeau +3 more
openaire +3 more sources