Results 261 to 270 of about 55,423 (289)

Braf + Egfr +/- Mek Inhibitors after Immune Checkpoint Inhibitors In Braf V600e Mutated and Deficient Mismatch Repair or Microsatellite Instability High Metastatic Colorectal Cancer

Margherita Ambrosini, David Tougeron, Dominik Paul Modest, Rosine Guimbaud, Scott Kopetz, Marie Decraecker, Stéfano Kim, Clélia Coutzac, Géraldine Perkins, Emily Alouani, Federica Marmorino, Simon Pernot, Frank A. Sinicrope, María Elena Elez, Pauline Parent, Chiara Cremolini, Filippo Pietrantonio, Sara Lonardi, Claire Gallois, Julien Taı̈eb   +19 more
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Microsatellite Instability and Myometrial Infiltration in Low-Grade Endometrial Cancer: A Focus on MMR Heterodimer Dysfunction by a Retrospective Multicentric Italian Study. [PDF]

J Pers Med
Ronsini C, Restaino S, Di Donna MC, Cucinella G, Solazzo MC, De Franciscis P, Vizzielli G, Ludovisi M, Chiantera V.   +8 more
europepmc   +1 more source

Artificial intelligence-driven microsatellite instability profiling reveals distinctive genetic features in patients with lung cancer. [PDF]

Cancer
Thomas QD, Vendrell JA, Khellaf L, Cavaillon S, Quantin X, Solassol J, Cabello-Aguilar S.   +6 more
europepmc   +1 more source

Correction to "Multi-sequence MRI-based clinical-radiomics models for the preoperative prediction of microsatellite instability-high status in endometrial cancer". [PDF]

Precis Radiat Oncol
europepmc   +1 more source

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Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Y R, Parc, K C, Halling
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Microsatellite instability

Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite instability: an update

Archives of Toxicology, 2015
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Hiroyuki, Yamamoto, Kohzoh, Imai
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Microsatellite instability in esophageal adenocarcinoma

Cancer Letters, 2004
The frequency of microsatellite instability (MSI), a result of defective mismatch repair during DNA replication, has been reported inconsistently in primary esophageal adenocarcinoma (EADC). Using a panel of 15 markers, the primary aim of this study was to analyze the frequency of MSI in a well-characterized series of 27 primary EADCs, defined ...
Susan C, Evans, Amy, Gillis, Laurette, Geldenhuys, Nadine M, Vaninetti, Dickran A, Malatjalian, Geoffrey A, Porter, Duane L, Guernsey, Alan G, Casson   +7 more
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Microsatellite instability in oral cancer

International Journal of Cancer, 1995
AbstractGeneralized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability.
C S, Ishwad, R E, Ferrell, K M, Rossie, B N, Appel, J T, Johnson, E N, Myers, J C, Law, S, Srivastava, S M, Gollin   +8 more
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Detection of Microsatellite Instability

2003
In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER).
K D, Berg, C A, Griffin, J R, Eshleman
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