Results 271 to 280 of about 55,423 (289)

Microsatellite Instability in Hematological Malignancies

Leukemia & Lymphoma, 2002
The replication error (RER+) phenotype, characterized by microsatellite instability (MSI) has been recently related to mutations of genes involved in DNA mismatch repair pathway. These genetic alterations were first described in hereditary non polyposis colorectal cancer (HNPCC). We examined 44 patients with hematological malignancies (27 AML, 9 MDS, 2
Lenka, Krsková-Honzátková, Jaroslav, Cermák, Jana, Sajdová, Jan, Starý, Petr, Sedlácek, Zuzana, Sieglová   +5 more
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Microsatellite instability in cervical carcinoma

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.A retrospective study of 100 cases of cervical carcinoma.MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical
T K, Chung, T Y, Ip, G M, Hampton, V W, Wang, T H, Cheung, Y F, Wong   +5 more
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Microsatellite instability in uterine sarcomas

International Journal of Gynecological Cancer, 2001
Studies have shown a 15-30% frequency of microsatellite instability in endometrial cancer. In addition, we found a 21% frequency of microsatellite instability in endometrial cancer. Our aim was to investigate the presence of microsatellite instability and loss of heterozygosity in uterine sarcomas.
Amant, F., Dorfling, C. M., Dreyer, L., Vergote, I., Lindeque, B. G., van Rensburg, E. J.   +5 more
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Microsatellite instability in gallbladder carcinoma

Virchows Archiv, 2015
The genetic abnormalities involved in the pathogenesis of gallbladder carcinoma (GBC) remain unclear. Microsatellite instability (MSI) has been described in many carcinomas, but little is known about the significance of mismatch repair in gallbladder carcinogenesis.
Andrea P, Moy, Mohammad, Shahid, Cristina R, Ferrone, Darrell R, Borger, Andrew X, Zhu, David, Ting, Vikram, Deshpande   +6 more
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Microsatellite instability in breast cancer

Annals of Surgical Oncology, 1997
Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of primary breast carcinoma surgical specimens.Using
E B, Rush, J E, Calvano, K J, van Zee, A D, Zelenetz, P I, Borgen   +4 more
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Microsatellite instability associated with hepatocarcinogenesis

Journal of Hepatology, 1999
The biological and clinicopathological significance of microsatellite instability in hepatocellular carcinoma still remains to be determined. The aim of this study was to assess the role of microsatellite instability in hepatocarcinogenesis.Genomic DNA extracted from 38 fresh samples of hepatocellular carcinoma was amplified by polymerase chain ...
Y, Kondo, Y, Kanai, M, Sakamoto, M, Mizokami, R, Ueda, S, Hirohashi   +5 more
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Microsatellite DNA Instability in COPD

Chest, 1999
Cigarette smoking is the prime cause of COPD; however, only a few smokers develop the disease. In a previous study, we demonstrated that microsatellite DNA instability (MSI) is a detectable phenomenon in sputum cells of COPD patients. Therefore, we hypothesize that this genetic alteration may indicate susceptibility to COPD.In order to investigate this
N M, Siafakas, E G, Tzortzaki, G, Sourvinos, D, Bouros, N, Tzanakis, A, Kafatos, D, Spandidos   +6 more
openaire   +2 more sources

Microsatellite Instability in Hematologic Malignancies

Leukemia & Lymphoma, 1997
Malignant transformation in humans occurs via different mechanisms including the activation of oncogenes and/or loss of tumor suppressor genes. Recently, DNA mismatch repair defects manifest as genome wide microsatellite instability have been described as an additional mechanism of tumorgenesis in humans.
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Microsatellite Instability

Nihon rinsho. Japanese journal of clinical medicine, 2012
Tamotsu, Sugai, Noriyuki, Uesugi, Wataru, Habano, Kazuyuki, Suzuki   +3 more
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Microsatellite Instability

2004
Wolfgang Dietmaier, Arndt Hartmann
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