Microsatellite instability (MSI, EMAST) in the pathogenesis of follicular lymphoma
Онкогематология, 2021 Background. Genetic instability, an important phenomenon involved in oncogenic transformation and tumor progression, is associated with the insufficiency of the multicomponent DNA repair complex, in particular, the nucleotide mismatch repair (MMR) system.
K. A. Sychevskaya +6 more
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Development and Validation of a Deep Learning-Based Microsatellite Instability Predictor from Prostate Cancer Whole-Slide Images [PDF]
, 2023 Qiyuan Hu +15 more
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Testing tumors for microsatellite instability [PDF]
European Journal of Human Genetics, 1999 The methods for determining microsatellite instability in tumors are highly heterogeneous. Recently a 5-marker panel of microsatellites was suggested for this purpose. In this review attention is drawn to the fact that microsatellite instability can be assessed by analyzing tumor DNA with a single marker, BAT-26, and that normal tissue DNA from the ...
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Cancer Nexus, EarlyView.Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa +2 more
wiley +1 more source
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. [PDF]
PLoS ONE, 2007 Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently.
Marcos R H Estécio +11 more
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Genomic and Immune Correlates of EZH2 Expression and Activity in Olfactory Neuroblastoma
Head &Neck, EarlyView.ABSTRACT Purpose Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy with limited therapeutic options in the recurrent/metastatic setting; little is known regarding its responsiveness to immunotherapy. Inhibition of enhancer of zeste homolog 2 (EZH2) has been shown to improve T‐cell‐mediated killing and susceptibility to immune checkpoint ...
Elisabetta Xue +12 more
wiley +1 more source
Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts
Virology Journal, 2012 Background Marek’s disease virus (MDV), an oncogenic α-herpes virus, causes a devastating disease in chickens characterized by development of lymphoblastoid tumors in multiple organs.
Zhou Zhenlei +3 more
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Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells
International Journal of Cancer, EarlyView.What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange +9 more
wiley +1 more source
Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR) w raku piersi
Menopause Review, 2010 Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers.
Hanna Romanowicz +6 more
doaj
Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
Neoplasia: An International Journal for Oncology Research, 2018 There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening.
Amy L. Cisyk +4 more
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