LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. [PDF]
PLoS ONE, 2007 Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently.
Marcos R H Estécio +11 more
doaj +1 more source
Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model. [PDF]
, 2012 Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.
Buschiazzo, Emmanuel +4 more
core +1 more source
Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts
Virology Journal, 2012 Background Marek’s disease virus (MDV), an oncogenic α-herpes virus, causes a devastating disease in chickens characterized by development of lymphoblastoid tumors in multiple organs.
Zhou Zhenlei +3 more
doaj +1 more source
Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR) w raku piersi
Menopause Review, 2010 Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers.
Hanna Romanowicz +6 more
doaj
Screening Relevance of Sessile Serrated Polyps [PDF]
, 2019 Conventional adenomas have historically been considered to be the only screening-relevant colorectal cancer (CRC) precursor lesion. The prevailing paradigm was that most CRCs arise along the chromosomal instability pathway, where adenomas accumulate ...
Kahi, Charles J.
core +1 more source
Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
Neoplasia: An International Journal for Oncology Research, 2018 There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening.
Amy L. Cisyk +4 more
doaj +1 more source
Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. [PDF]
, 2007 Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive ...
Agnese, V. +13 more
core +1 more source
Editorial: Microsatellite and microsatellite instability
Frontiers in Genetics, 2023 Alexandre How-Kit +5 more
doaj +1 more source
Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]
, 2015 Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier +2 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2020 Background Microsatellite instability in colon cancer implies favorable therapeutic outcomes after checkpoint blockade immunotherapy. However, the molecular nature of microsatellite instability is not well elucidated.Methods We examined the immune ...
Wei Wu +12 more
doaj +1 more source