Results 81 to 90 of about 859,289 (399)

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

JAMA Oncology, 2019
Importance The anti–programmed cell death protein 1 (PD-1) antibody pembrolizumab is approved by the US Food and Drug Administration for the treatment of microsatellite instability–high (MSI-H) or mismatch repair–deficient (dMMR) solid tumors, but the ...
W. Abida, M. Cheng, J. Armenia, S. Middha, K. Autio, H. Vargas, D. Rathkopf, M. Morris, D. Danila, S. Slovin, E. Carbone, E. Barnett, Melanie A. Hullings, J. Hechtman, A. Zehir, J. Shia, P. Jonsson, Z. Stadler, P. Srinivasan, V. Laudone, V. Reuter, J. Wolchok, N. Socci, B. Taylor, M. Berger, P. Kantoff, C. Sawyers, N. Schultz, D. Solit, A. Gopalan, H. Scher   +30 more
semanticscholar   +1 more source

A radiological complete response to pembrolizumab in a patient with metastatic upper urinary tract urothelial cancer and Lynch syndrome

IJU Case Reports, Volume 6, Issue 1, Page 33-36, January 2023., 2023
Introduction In Lynch syndrome, urothelial cancer is the third most common cancer, following colorectal and endometrial cancers. Little is known, however, about the efficacy of immune checkpoint inhibitors in the treatment of metastatic urothelial cancer in Lynch syndrome.
Ryosuke Oki, Tetsuya Urasaki, Arisa Ueki, Kentaro Inamura, Yoshinobu Komai, Shunji Takahashi, Junji Yonese, Takeshi Yuasa   +7 more
wiley   +1 more source

Microsatellite instability in endometrial polyps [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010
To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25,
Rosângela Vieira de Andrade, Érica Carvalho Caldas, Nathan R. Wall, Salete da Silva Rios, Khaled Bahjri, Florêncio Figueiredo, Florêncio Figueiredo, Larissa Cavalcante, Rinaldo Wellerson Pereira   +8 more
openaire   +2 more sources

A molecular portrait of microsatellite instability across multiple cancers

Nature Communications, 2017
Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to
Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim, Peter J. Park   +4 more
doaj   +1 more source

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.

Journal of Clinical Oncology, 2019
PURPOSE Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and endometrial cancer (EC) to screen for Lynch syndrome (LS)-associated cancer predisposition ...
Alicia J Latham, P. Srinivasan, Y. Kemel, J. Shia, C. Bandlamudi, D. Mandelker, S. Middha, J. Hechtman, A. Zehir, Marianne E. Dubard-Gault, Christina Tran, Carolyn Stewart, M. Sheehan, A. Penson, D. DeLair, R. Yaeger, J. Vijai, Semanti Mukherjee, Jesse Galle, M. Dickson, Y. Janjigian, E. O’Reilly, N. Segal, L. Saltz, D. Reidy‐Lagunes, A. Varghese, D. Bajorin, M. Carlo, K. Cadoo, M. Walsh, M. Weiser, J. G. Aguilar, D. Klimstra, L. Diaz, J. Baselga, Liying Zhang, M. Ladanyi, D. Hyman, D. Solit, M. Robson, B. Taylor, K. Offit, M. Berger, Z. Stadler   +43 more
semanticscholar   +1 more source

Mismatch Repair Deficiency and Microsatellite Instability

Encyclopedia, 2022
Mismatch repair deficiency (MMRd) is caused by the biallelic inactivation of an MMR gene, which can be attributed either to an inherited or an acquired pathway.
Sandra Schöniger, Josef Rüschoff
doaj   +1 more source

XDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System In Colorectal Cancer [PDF]

arXiv, 2021
We present a system for the prediction of microsatellite instability (MSI) from H&E images of colorectal cancer using deep learning (DL) techniques customized for tissue microarrays (TMAs). The system incorporates an end-to-end image preprocessing module that produces tiles at multiple magnifications in the regions of interest as guided by a tissue ...
arxiv  

Development and Validation of a Deep Learning-Based Microsatellite Instability Predictor from Prostate Cancer Whole-Slide Images [PDF]

arXiv, 2023
Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction of MSI status from hematoxylin and eosin (H&E) stained whole-slide images (WSIs) could identify prostate cancer ...
arxiv  

The order of surgery and chemotherapy matters: Multimodality therapy and stage‐specific differences in survival in gastric cancer

Journal of Surgical Oncology, Volume 127, Issue 1, Page 56-65, January 2023., 2023
Abstract Background and Objectives Multimodality treatment improves survival for gastric cancer (GC). However, the effect of treatment sequence by stage remains unclear. We aim to compare outcomes between patients receiving neoadjuvant(neoadj) and adjuvant chemotherapy (adj).
Vicente Ramos‐Santillan, Patricia Friedmann, Mariam Eskander, Jennifer Chuy, Michael Parides, Haejin In   +5 more
wiley   +1 more source

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source