Results 261 to 270 of about 57,676 (330)

Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence suggests NOTCH activation is among the survival and proliferation pathways interacting with FOXL2 c.402C > G (p.Cys134Trp) mutation in granulosa cell tumours (GCT). This Phase II clinical trial of nirogacestat in GCT achieved its enrolment target in < 1 year and primary analysis within 2 years.
Rachel N. Grisham, Elizabeth Hopp, Kathryn Pennington, Robert Holloway, Robert M. Wenham, Pawel Blecharz, Lauren Dockery, Koji Matsuo, Ritu Salani, Mariusz Bidzinski, Patricia Braly, Paul Celano, Thomas Reid, Shelly Seward, Jocelyn Lewis, Mark Johnson, Robert DuBose, Sarah Ahn, Shinta Cheng, Carmelita Alvero, Panagiotis A. Konstantinopoulos   +20 more
wiley   +1 more source

The Application of Microsatellite Markers as Molecular Tools for Studying Genomic Variability in Vertebrate Populations. [PDF]

Curr Issues Mol Biol
Kulibaba RO, Srikulnath K, Singchat W, Liashenko YV, Griffin DK, Romanov MN.   +5 more
europepmc   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

Silent Persistence: Molecular Evidence of Clonal Transmission in Fluconazole-Resistant <i>Candida parapsilosis</i> Hospital Outbreaks over Decades. [PDF]

J Fungi (Basel)
Semet C, Kazak E, Ak-Aksoy S, Ağca H, Ener B.   +4 more
europepmc   +1 more source

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Overview of study design. Metagenomic and plasma/fecal metabolomic studies were performed in 44 NSCLC patients who underwent neoadjuvant tislelizumab therapy plus platinum ‐ based doublet chemotherapy. Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage ...
Ailing Cao, Yaobin Lin, Shaoxing Guan, Youhao Chen, Wenyu Zhai, Yuheng Zhou, Shoucheng Feng, Yanping Guan, Yiyu Zhang, Min Huang, Xueding Wang, Hao Long   +11 more
wiley   +1 more source

The plastid genome of the critically endangered Valeriana trinervis (= Centranthus trinervis) and insights from comparison with other Valeriana plastomes (Caprifoliaceae). [PDF]

Planta
De Luca D, De Castro O.
europepmc   +1 more source

Multi‐omics analysis identifies PUS7 as an immune modulator driving NETs‐mediated macrophage polarization in pancreatic cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
PUS7 reshapes the PDAC immune landscape primarily by inducing NETs, which drive macrophage polarization from M1 to M2, fostering immune suppression and tumour progression. The inhibitory effects of S428‐1145 and DNase I on pancreatic cancer are mediated through blocking the PUS7/NETs/M2 macrophage pathway.
Jike Fang, Shiye Ruan, Yajie Wang, Yue Chen, Fuxin Huang, Zhongyan Zhang, Chuanzhao Zhang, Baohua Hou, Shanzhou Huang   +8 more
wiley   +1 more source

Oxidative stress accelerates repeat sequence instability and base substitutions promoting gastrointestinal driver mutations in MSH2 deficient mice. [PDF]

Genes Environ
Ohno M, Takano N, Hidaka K, Sasaki F, Aoki Y, Nohmi T, Tsuzuki T.   +6 more
europepmc   +1 more source

Reverse Random Amplified Microsatellite Polymorphism Reveals Enhanced Polymorphisms in the 3′ End of Simple Sequence Repeats in the Pepper Genome

, 2008
Woong-Ki Min, Jung-Heon Han, Won‐Hee Kang, Heung-Ryul Lee, Byung-Dong Kim   +4 more
openalex   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source