Results 81 to 90 of about 28,396 (290)

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer   +11 more
wiley   +1 more source

Characterization of Waxy microsatellite classes that are closely linked to the rice Waxy gene and amylose content in Thai rice germplasm [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2003
Sixty-eight strains belonging to two species of Oryza were characterized by using Wx microsatellite, (CT)n repeats that are closely linked to the rice Waxy gene.
Preecha Prathepha
doaj  

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia   +4 more
wiley   +1 more source

Detection of MSI signals from peripheral blood for monitoring response to immune checkpoint blockade therapy in patients with advanced microsatellite‐unstable gastrointestinal cancers: A pilot study

open access: yesInternational Journal of Cancer, EarlyView.
What's New? A substantial proportion of patients with microsatellite‐unstable gastrointestinal adenocarcinomas do not benefit from immunotherapy. This study demonstrates that microsatellite instability can be reliably detected in plasma‐derived extracellular vesicle DNA from patients with microsatellite‐unstable gastrointestinal cancers.
Aysel Ahadova   +16 more
wiley   +1 more source

Isolation and Characterization of 20 Polymorphic Microsatellite Markers for Juglans mandshurica (Juglandaceae)

open access: yesApplications in Plant Sciences, 2013
Premise of the study: Fifty microsatellite loci were developed for the endangered species Juglans mandshurica to investigate its genetic diversity and population structure.
Chang-Mei Chen   +4 more
doaj   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

open access: yesiMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang   +3 more
wiley   +1 more source

Microsatellite Primers in the Lichen Symbiotic Alga Trebouxia decolorans (Trebouxiophyceae)

open access: yesApplications in Plant Sciences, 2013
Premise of the study: Polymorphic microsatellite markers were developed for the symbiotic green alga Trebouxia decolorans to study fine-scale population structure and clonal diversity.
Francesco Dal Grande   +3 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

open access: yesiMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang   +31 more
wiley   +1 more source

Life Stage‐Specific Genetic Diversity and Landscape Characteristics Collectively Influence Genetic Recovery in Pometia pinnata Population 生活史阶段特异的遗传多样性与景观特征对番龙眼种群遗传恢复的协同影响

open access: yesIntegrative Conservation, EarlyView.
Pometia pinnata demonstrated life‐stage‐specific genetic responses to landscape features, with asymmetric gene flow patterns and population recovery following historical bottlenecks, revealing complex topographic and demographic influences on forest genetic structure.
Madhuparna Chatterjee   +5 more
wiley   +1 more source

Application of a double-enrichment procedure for microsatellite isolation and the use of tailed primers for high throughput genotyping

open access: yesGenetics and Molecular Biology, 2007
The number of microsatellite loci and their allelic diversity contribute to increase accuracy and informativity of genetic estimates, however, the isolation of microsatellite loci is not only laborious but also quite expensive.
Fábio Mendonça Diniz   +4 more
doaj   +1 more source

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