Results 81 to 90 of about 55,724 (327)

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Analysis of microsatellite aberrations and loss of heterozygosity in follicular lymphoma, diffuse large B-cell lymphoma, and high-grade B-cell lymphoma patients

Онкогематология, 2022
Background. The study of genetic predictors of non-Hodgkin’s lymphomas prognosis is one of the most relevant areas of oncohematology. It is extremely interesting to search for integral markers that reflect the most important stages of tumor pathogenesis.
K. A. Sychevskaya, A. E. Misyurina, E. E. Nikulina, N. V. Risinskaya, R. R. Abdurashidova, Z. T. Sarakaeva, A. U. Magomedova, A. B. Sudarikov, S. K. Kravchenko   +8 more
doaj   +1 more source

PCR-based characterisation of entomopathogenic fungi for ecological studies [PDF]

, 2008
The implementation of PCR-based tools for characterisation of organisms has greatly advanced our understanding of the phylogenies and species boundaries in entomopathogenic fungi, especially the widespread taxa Beauveria bassiana and Metarhizium ...
Meyling, Nicolai V.
core  

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

Advanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu, Mengxi Xiu, Shijun Yu, Zhiqin Chen, Yandong Li, Yong Gao   +5 more
wiley   +1 more source

Climatic niche and neutral genetic diversity of the six Iberian pine species: a retrospective and prospective view [PDF]

, 2010
Quaternary climatic fluctuations have left contrasting historical footprints on the neutral genetic diversity patterns of existing populations of different tree species.
Soto de Viana, Álvaro
core   +2 more sources

Isolation and characterization of dinucleotide repeat microsatellites in Drosophila ananassae

Genetical Research, 2004
Drosophila ananassae is a cosmopolitan species with a geographic range throughout most of the tropical and subtropical regions of the world. Previous studies of DNA sequence polymorphism in three genes has shown evidence of selection affecting broad expanses of the genome in regions with low rates of recombination in geographically local populations in
Schug, M.D., Regulski, E.E., Pearce, A., Smith, S.G.   +3 more
openaire   +3 more sources

Quasimonomorphic Mononucleotide Repeats for High‐Level Microsatellite Instability Analysis [PDF]

Disease Markers, 2004
Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non‐Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phenotype, a meeting held in Bethesda ...
Asad Umar, Olivier Buhard, Nirosha Suraweera, Aude Lectard, Alex Duval, Richard Hamelin   +5 more
openaire   +2 more sources

Radiomics‐Based Unsupervised Clustering Identifies Subtypes Associated With Prognosis and Immune Microenvironment in Clear Cell Renal Cell Carcinoma: A Multicenter Study

Advanced Science, EarlyView.
This study developed an unsupervised radiomics system integrating CT imaging and multi‐omics data to stratify clear cell renal cell carcinoma into two subtypes with distinct clinical outcomes. Cluster 1 showed lower recurrence risk and active immunity, while Cluster 2 exhibited higher recurrence risk, enriched VHL/KDM5C mutations, immunosuppressive ...
Yusheng Guo, Bingxin Gong, Yi Li, Jie Lou, Shuai Shan, Xiaodong Zhang, Qiang Lu, Dongyong Zhu, Qing Sun, Lianwei Miao, Yuanxi Li, Yu‐Dong Zhang, Wei Tan, Lian Yang, Chuansheng Zheng   +14 more
wiley   +1 more source

Characterization of new Schistosoma mansoni microsatellite loci in sequences obtained from public DNA databases and microsatellite enriched genomic libraries

Memorias do Instituto Oswaldo Cruz, 2002
In the last decade microsatellites have become one of the most useful genetic markers used in a large number of organisms due to their abundance and high level of polymorphism. Microsatellites have been used for individual identification, paternity tests,
NB Rodrigues, PT LoVerde, AJ Romanha, G Oliveira   +3 more
doaj   +1 more source