Results 241 to 250 of about 1,751,921 (298)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Macroscopic and histological analyses of cremated remains from the Imperial Roman necropolis of La Cona (1st cent. BCE-1st cent. CE, Teramo, Italy). [PDF]

PLoS One
Galbusera A, Magri S, Higgins OA, Trevisan M, Prillo VG, Vidale M, Torrieri V, Benazzi S, Bondioli L, Nava A, Gigante M.   +10 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Comparative evaluation of enzymatic, acidic, and alkaline digestion protocols for organic matrix removal from lyophilized and frozen mussel samples (<i>Mytilus galloprovincialis</i>). [PDF]

Front Toxicol
Turmanova S, Hristov Y, Kiryakova D, Ivanova E, Atanasova P, Kolchakova G, Ilieva A, Mollova E, Dimitrov A, Todorov N, Grigorova G.   +10 more
europepmc   +1 more source

ANCA-associated vasculitis is associated with an increased risk of cardiac and vascular morbidity: results of a large-scale propensity-matched global retrospective cohort study. [PDF]

Front Immunol
Klapa S, Bieber K, Vorobyev A, Ludwig M, Vollert G, Arnold S, Olbrich H, Nording H, Müller A, Kridin K, Schirmer JH, von Allwörden K, Staehle A, Ludwig R, Lamprecht P.   +14 more
europepmc   +1 more source

Scleroderma renal crisis: avoiding the diagnostic pitfalls of an elusive condition. [PDF]

Rheumatol Adv Pract
Ng IKS, Tang MS, See FH, Cho J.
europepmc   +1 more source

Gluten Catastrophe: A Fatal Case of Refractory Celiac Disease Type 2. [PDF]

ACG Case Rep J
Thakkar B, Hagen R, Robert ME, Nguyen MTT.   +3 more
europepmc   +1 more source

Models for Training in Pediatric Otologic Surgery: A Systematic Review. [PDF]

Children (Basel)
Carlotto E, Cirillo S, Marconi S, Pisani S, Bertozzi M, Chiapperini C, Mauramati S, Benazzo M, Canzi P.   +8 more
europepmc   +1 more source

Swept-source intraoperative optical coherence tomography for real-time detection of anterior segment membranes during cataract surgery: a case series. [PDF]

Quant Imaging Med Surg
Fang J, Shi C, Ma X, Liu C, Sheng S, Yao M, Yan W, Xu Z, Xu W.   +8 more
europepmc   +1 more source