Results 171 to 180 of about 277,529 (354)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Optimization of image operators for microscopic image segmentation
, 2018 Delo obravnava obdelavo mikroskopskih slik celic oz. tkiv na podlagi večstopenjske digitalne obdelave slik. Namen je bila optimizacija morfoloških operatorjev za segmentacijo mikroskopskih slik.
Avberšek, Tomaž
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Three-Dimensional Microscopic Image Reconstruction Based on Structured Light Illumination. [PDF]
Sensors (Basel), 2021 Shi T, Qi Y, Zhu C, Tang Y, Wu B.
europepmc +1 more source
Coherent field emission image of graphene predicted with a microscopic theory [PDF]
, 2012 Zhibing Li, Ningsheng Xu, H. J. Kreuzer
openalex +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Color-Coded Droplets and Microscopic Image Analysis for Multiplexed Antibiotic Susceptibility Testing. [PDF]
Biosensors (Basel), 2021 Jeong Y +6 more
europepmc +1 more source
Efficient high-resolution microscopic ghost imaging via sequenced speckle illumination and deep learning from a single noisy image [PDF]
Sukyoon Oh +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Infrared Microscopic Imaging Analysis
Proceedings of the 13th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications, 2018 Anselmo Jara +3 more
openaire +1 more source