Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Automated Detection of Parasitic Elements in Veterinary Fecal Samples Using a Deep Learning-Based Object Detection Framework. [PDF]
Yang J +4 more
europepmc +1 more source
Neutron scattering analysis with microscopic optical model potentials
L.F. Hansen
openalex +1 more source
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
MBMSA-UNet: A Multi-Scale Attention-Based Instance Segmentation Model for Moso Bamboo Cells. [PDF]
Zhou X +7 more
europepmc +1 more source
Microscopic cluster model of elastic scattering and bremsstrahlung of light nuclei
Jérémy Dohet-Eraly +2 more
openalex +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Characterising Epigenetic Tipping Points using a Spectral Dimension Reduction Approach. [PDF]
Alarcón T, Menendez JA, Sardanyés J.
europepmc +1 more source
Publisher's Note: “Fast water flow through graphene nanocapillaries: A continuum model approach involving the microscopic structure of confined water” [Appl. Phys. Lett. 113, 083101 (2018)] [PDF]
M. Neek-Amal +5 more
openalex +1 more source

