Results 241 to 250 of about 14,500,098 (303)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Boosting low-resolution algae detection via cross-resolution knowledge distillation and transfer learning. [PDF]

Front Microbiol
Jiang M, Yang M, Wu Y, Zheng H.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Channel-resolved excitation trends in Si, GaAs, and NiO for sub-GeV dark matter detection. [PDF]

Sci Rep
Sharaf MAM.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Vaginal <i>Lactobacillus</i> spp. Dominance in Late Pregnancy and Neonatal Anthropometric Outcomes: A Prospective Observational Study. [PDF]

J Clin Med
Atomei OL, Lobiuc A, Vicoveanu P, Cobuz M, Tarcea M.   +4 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Exploratory machine learning-based early post-treatment assessment of willingness to reuse rubber dam isolation after microscopic root canal treatment. [PDF]

J Int Med Res
Cai Y, Xiang T, Sun Q, Guan L, Zhao C.
europepmc   +1 more source

Artificial intelligence in non-small cell lung cancer: transforming diagnosis, treatment, and prognostic evaluation. [PDF]

Front Med (Lausanne)
Zheng S, Lv C, Yao Z.
europepmc   +1 more source

Entropic Phenomena in Spin-Ice Materials and Magnetic Monopole Excitations. [PDF]

Entropy (Basel)
Chappa A, Miao L.
europepmc   +1 more source