Results 171 to 180 of about 2,913 (260)

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Vibration Control and Micro-Forming Quality Guarantee of BMF-Based UHPC Wet Joints Under Traffic Loads Using Tuned Mass Dampers. [PDF]

Materials (Basel)
Wang Z, Zhang L, Zhou C, Wang P.
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Reinforcement learning for dynamic speed control in connected and autonomous vehicles: A review of applications and challenges. [PDF]

iScience
Alhmiedat T, Albelwi S, Alotaibi M, Mustafa M, Alquier F, Gochoo M, Alnajjar F.   +6 more
europepmc   +1 more source

Exact and metaheuristic approaches to minimizing makespan in parallel machine scheduling with conflicting jobs

International Transactions in Operational Research, EarlyView.
Abstract We address the scheduling conflicting jobs on parallel identical machines problem with makespan minimization, a classical and computationally challenging variant of parallel machine scheduling. We develop and evaluate three distinct solution methodologies: a novel constraint programming (CP) formulation, and two metaheuristics: a multi ...
Roberto Maria Rosati, Dinh Quy Ta, Minh Hoàng Hà, Andrea Schaerf   +3 more
wiley   +1 more source

Optimizing Urban Traffic Efficiency and Safety via V2X: A Simulation Study Using the MOSAIC Platform. [PDF]

Sensors (Basel)
Alupoaei SI, Caruntu CF.
europepmc   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

Journal of Integrative Plant Biology, EarlyView.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang, Junyan Xie, Yiping Zou, Chunliang Yao, Hai Fan, Chenqi Shen, Wenyan Zhou, Jingran Qin, Xinke Zhang, Baoshan Wang, Jian Zhang, Guoliang Han   +11 more
wiley   +1 more source

Bilevel multiobjective control enhances arterial performance via spatiotemporal optimization of presignalized intersections. [PDF]

Sci Rep
Pan J, Yang Q, Li P.
europepmc   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

Multiscale Damage and Failure Behavior of Drainage Asphalt Mixture Under Multifactor. [PDF]

Materials (Basel)
Tao X, Bai T, Fan J, Shen H, Cheng H.
europepmc   +1 more source