Results 71 to 80 of about 8,924,569 (266)
Malaria JournalIntroduction Accurate diagnosis of malaria, caused by Plasmodium falciparum, remains challenging in endemic resource-limited settings. Molecular diagnostics, like PCR, offer a higher sensitivity, but are often impractical at the point-of-care.
Francois Kiemde +9 more
doaj +1 more source
The Ratio of Smear-Negative Tuberculosis in Sindh: An insight using Fluorescence Microscopy
JLUMHS, 2017 BACKGROUND: Sputum smear microscopy is the most useful tool used for the screening of presumptive tuberculosis cases. Conventionally Ziehl-Neelsen (ZN) based staining is used to microscopically screen sputum from the presumptive Tuberculosis Cases ...
Muhammad Yahya Noori +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Atomic Force Microscopy Imaging of Living Cells [PDF]
, 2010 Over the last two decades, Atomic Force Microscopy (AFM) has emerged as the tool of choice to image living organisms in a near-physiological environment.
Berquand, Alexandre +17 more
core +2 more sources
Diagnosis of malaria among children in Sokoto: A comparison of microscopy and Rapid Diagnostic Tests
UMYU Journal of Microbiology ResearchMalaria is a life-threatening disease primarily found in tropical countries, and it is the leading cause of morbidity and mortality among children. Diagnosis of malaria depends largely on clinical presentations and laboratory diagnosis.
M U Kalgo +3 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 1970 Light emitting diode (LED) fluorescence microscopy offers well described benefits compared with brightfield microscopy by Ziehl-Neelsen stained sputum, even which are smear negative.
Md Quddusur Rahman +4 more
core +1 more source
International Journal of Microbiology, 2014 We quantify the false-negative diagnostic rate of septic arthritis using Gram-stain microscopy of synovial fluid and compare this to values reported in the peer-reviewed literature.
Paul Stirling +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source