Results 21 to 30 of about 1,221 (137)

Bayesian Calibration of Microsimulation Models [PDF]

Journal of the American Statistical Association, 2009
Microsimulation models that describe disease processes synthesize information from multiple sources and can be used to estimate the effects of screening and treatment on cancer incidence and mortality at a population level. These models are characterized by simulation of individual event histories for an idealized population of interest ...
Rutter, Carolyn M., Miglioretti, Diana L., Savarino, James E.   +2 more
openaire   +3 more sources

Microsimulation for demography

Australian Population Studies, 2017
Background: Microsimulation consists of a set of techniques for estimating characteristics and modelling change in populations of individuals. Aims: To demonstrate how microsimulation can be used by demographers who want to undertake population estimates and projections.
Lomax, NM, Smith, AP
openaire   +4 more sources

Evaluating risk factor assumptions: a simulation-based approach

BMC Medical Informatics and Decision Making, 2011
Background Microsimulation models are an important tool for estimating the comparative effectiveness of interventions through prediction of individual-level disease outcomes for a hypothetical population.
Miglioretti Diana L, Rutter Carolyn M, Savarino James E   +2 more
doaj   +1 more source

Multi-model traffic microsimulations [PDF]

Proceedings of the 2009 Winter Simulation Conference (WSC), 2009
sponsorship: This research was funded by the IWT - SBO project ‘MASE’ (project no. 060823) and by the Interuniversity Attraction Poles Programme Belgian State, Belgian Science Policy, and by the Research Fund K.U.Leuven.
Claes, Rutger, Holvoet, Tom
openaire   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

The Role of Research in the Basic Income Debate in the UK

LSE Public Policy Review, 2020
This paper will explore a variety of aspects of the current debate on Basic Income in the UK. It will survey the different kinds of research that have been carried out, and will identify where research results have informed the debate, where they have ...
Malcolm Torry
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Inside CKD: Cost-Effectiveness of Multinational Screening for CKD

Kidney International Reports
Introduction: Early detection of chronic kidney disease (CKD) could slow its progression; however, most patients in earlier stages remain undiagnosed. Our study objective was to assess the cost-effectiveness of multinational CKD screening strategies from
Navdeep Tangri, Kook-Hwan Oh, Jason C.J. Choo, Michel Jadoul, Johan Ärnlöv, Marcelo Costa Batista, Christian F. Christiansen, Gil Chernin, Lise Retat, Joshua Card-Gowers, Timothy Coker, Salvatore Barone, Stephen Nolan, Juan Jose Garcia Sanchez   +13 more
doaj   +1 more source