Results 31 to 40 of about 6,333 (188)

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Simulating family life courses: An application for Italy, Great Britain, Norway, and Sweden

Demographic Research, 2021
Background: Family patterns in Western countries have changed substantially across birth cohorts. The spread of unmarried cohabitation, the decline and postponement of marriage and fertility, and the rise in nonmarital births, partnership instability ...
Maria Winkler-Dworak, Eva Beaujouan, Paola Di Giulio, Martin Spielauer   +3 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Inside CKD: Cost-Effectiveness of Multinational Screening for CKD

Kidney International Reports
Introduction: Early detection of chronic kidney disease (CKD) could slow its progression; however, most patients in earlier stages remain undiagnosed. Our study objective was to assess the cost-effectiveness of multinational CKD screening strategies from
Navdeep Tangri, Kook-Hwan Oh, Jason C.J. Choo, Michel Jadoul, Johan Ärnlöv, Marcelo Costa Batista, Christian F. Christiansen, Gil Chernin, Lise Retat, Joshua Card-Gowers, Timothy Coker, Salvatore Barone, Stephen Nolan, Juan Jose Garcia Sanchez   +13 more
doaj   +1 more source

The Spanish income tax reform of 2015: analysis of the effects on poverty and redistribution using microsimulation tools

Public Sector Economics, 2017
In this work we analyze the effects of the 2015 reform of the Spanish personal income tax (PIT) on tax revenue, liquidity, redistribution, progressivity, and poverty, using microdata. Tax reform has increased the redistributive effect.
Nuria Badenes-Plá, José María Buenaventura-Zabala   +1 more
doaj   +1 more source

Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic

eLife, 2023
The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening.
Pedro Nascimento de Lima, Rosita van den Puttelaar, Anne I Hahn, Matthias Harlass, Nicholson Collier, Jonathan Ozik, Ann G Zauber, Iris Lansdorp-Vogelaar, Carolyn M Rutter   +8 more
doaj   +1 more source

The OncoSim-Breast cancer microsimulation model [PDF]

Current Oncology, 2020
ABSTRACT Background The increasing demand for health care resources requires measures to evaluate the impact of cancer control approaches. A cancer simulation model can help integrate new knowledge to inform clinical and policy decisions. OncoSim-Breast is a breast cancer simulation model. This paper
Jean H. E. Yong, Claude Nadeau, William M. Flanagan, Andrew J. Coldman, Keiko Asakawa, Rochelle Garner, Natalie Fitzgerald, Martin J. Yaffe, Anthony B. Miller   +8 more
openaire   +5 more sources

Evaluating the Impact of Age on Prostate Cancer Overdiagnosis Using Long‐Term Follow‐Up From the CAP Randomised Trial

International Journal of Cancer, EarlyView.
Uncertainty persists over whether the benefits of prostate‐specific antigen (PSA) screening outweigh harms from overdiagnosis, a key barrier to population‐wide adoption. Here, English male mortality rates were analyzed alongside long‐term data from the UK Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) to estimate age‐specific ...
Adam R. Brentnall, Matejka Rebolj, Peter Sasieni, Garth Funston, Rhian Gabe, Andrew J. Vickers   +5 more
wiley   +1 more source

Heuristic Fuzzy Approach to Traffic Flow Modelling and Control on Urban Networks

Future Internet
Computer-aided transport modelling is essential for testing different control strategies for traffic lights. One approach to modelling traffic control is by heuristically defining fuzzy rules for the control of traffic light systems and applying them to ...
Alexander Gegov, Boriana Vatchova, Yordanka Boneva, Alexandar Ichtev   +3 more
doaj   +1 more source

Profitability Optimization of Dairy Farms: The Effect of Pregnancy Rate and Culling Decision

Animals, 2023
One of the most important decisions in dairy cattle production today is the correct choice of culling time for cows. In the culling decision process, the farmer has to take into account a number of factors, the complexity of which makes the decision ...
Violetta Tóth, Emília Heinc, Edit Mikó, Tibor Csendes, Balázs Bánhelyi   +4 more
doaj   +1 more source