Results 31 to 40 of about 32,956 (230)

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Inside CKD: Cost-Effectiveness of Multinational Screening for CKD

Kidney International Reports
Introduction: Early detection of chronic kidney disease (CKD) could slow its progression; however, most patients in earlier stages remain undiagnosed. Our study objective was to assess the cost-effectiveness of multinational CKD screening strategies from
Navdeep Tangri, Kook-Hwan Oh, Jason C.J. Choo, Michel Jadoul, Johan Ärnlöv, Marcelo Costa Batista, Christian F. Christiansen, Gil Chernin, Lise Retat, Joshua Card-Gowers, Timothy Coker, Salvatore Barone, Stephen Nolan, Juan Jose Garcia Sanchez   +13 more
doaj   +1 more source

The Spanish income tax reform of 2015: analysis of the effects on poverty and redistribution using microsimulation tools

Public Sector Economics, 2017
In this work we analyze the effects of the 2015 reform of the Spanish personal income tax (PIT) on tax revenue, liquidity, redistribution, progressivity, and poverty, using microdata. Tax reform has increased the redistributive effect.
Nuria Badenes-Plá, José María Buenaventura-Zabala   +1 more
doaj   +1 more source

Cost‐effectiveness of risk‐stratified screening for cervical cancer in cohorts vaccinated against human papillomavirus with moderate vaccination coverage

International Journal of Cancer, EarlyView.
What's New? Effective cervical cancer prevention centers around screening and testing for human papillomavirus (HPV) infection. With birth cohorts of HPV‐vaccinated women now reaching screening‐eligible ages, however, the best means to maintaining cost‐effective cervical cancer screening is unclear.
Tiago M. de Carvalho, Johannes Berkhof, Johannes A. Bogaards   +2 more
wiley   +1 more source

Heuristic Fuzzy Approach to Traffic Flow Modelling and Control on Urban Networks

Future Internet
Computer-aided transport modelling is essential for testing different control strategies for traffic lights. One approach to modelling traffic control is by heuristically defining fuzzy rules for the control of traffic light systems and applying them to ...
Alexander Gegov, Boriana Vatchova, Yordanka Boneva, Alexandar Ichtev   +3 more
doaj   +1 more source

WHAT HAS HAPPENED TO REPLACEMENT RATES? ESRI Working Paper No. 76, May 1996 [PDF]

, 1996
Financial incentives to take up and stay in work, and the impact of the tax and social welfare systems on these incentives, have become a major preoccupation of Irish policy-makers. Recent Budgets have highlighted measures to "reward work" through income
Callan, Tim, Nolan, Brian, O'Donoghue, Cathal   +2 more
core  

Comparing the effectiveness of prostate cancer screening protocols: European Association of Urology– and European Randomized Study of Screening for Prostate Cancer–based strategies

International Journal of Cancer, EarlyView.
What's New? Although screening reduces prostate cancer mortality, concerns about overdiagnosis and unnecessary biopsies have given rise to more tailored strategies. The European Association of Urology (EAU) proposed a risk‐adapted screening strategy combining prostate‐specific antigen (PSA)‐based intervals, a risk calculator, and magnetic resonance ...
Zhenwei Yang, Luuk A. van Duuren, Monique J. Roobol, Nicole S. Erler, Dimitris Rizopoulos, Eveline A. M. Heijnsdijk   +5 more
wiley   +1 more source

Method to Use Transport Microsimulation Models to Create Synthetic Distributed Acoustic Sensing Datasets

Applied Sciences
This research introduces a new method for creating synthetic Distributed Acoustic Sensing (DAS) datasets from transport microsimulation models. The process involves modeling detailed vehicle interactions, trajectories, and characteristics from the PTV ...
Ignacio Robles-Urquijo, Juan Benavente, Javier Blanco García, Pelayo Diego Gonzalez, Alayn Loayssa, Mikel Sagues, Luis Rodriguez-Cobo, Adolfo Cobo   +7 more
doaj   +1 more source

Common and Foral IRPF after the 1998 reform: analysis of the differences of collection and redistribution through microsimulation [PDF]

Investigaciones Regionales - Journal of Regional Research, 2003
After the reforms introduced in Spanish personal income tax (IRPF) in 1998, foral and common territory tax structures present differentiated structures. These normative differences are reviewed in the first part of the paper.
Francisco José Delgado Rivero
doaj