Results 31 to 40 of about 20,472 (228)

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Inside CKD: Cost-Effectiveness of Multinational Screening for CKD

Kidney International Reports
Introduction: Early detection of chronic kidney disease (CKD) could slow its progression; however, most patients in earlier stages remain undiagnosed. Our study objective was to assess the cost-effectiveness of multinational CKD screening strategies from
Navdeep Tangri, Kook-Hwan Oh, Jason C.J. Choo, Michel Jadoul, Johan Ärnlöv, Marcelo Costa Batista, Christian F. Christiansen, Gil Chernin, Lise Retat, Joshua Card-Gowers, Timothy Coker, Salvatore Barone, Stephen Nolan, Juan Jose Garcia Sanchez   +13 more
doaj   +1 more source

The Spanish income tax reform of 2015: analysis of the effects on poverty and redistribution using microsimulation tools

Public Sector Economics, 2017
In this work we analyze the effects of the 2015 reform of the Spanish personal income tax (PIT) on tax revenue, liquidity, redistribution, progressivity, and poverty, using microdata. Tax reform has increased the redistributive effect.
Nuria Badenes-Plá, José María Buenaventura-Zabala   +1 more
doaj   +1 more source

Long‐term cost‐effectiveness of belatacept vs. tacrolimus in kidney transplantation: Trade‐off between metabolic benefit and immunological risk

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the long‐term cost‐effectiveness of belatacept vs. tacrolimus as maintenance immunosuppression in adult kidney transplant recipients, focusing on the trade‐off between reduced new‐onset diabetes after transplantation (NODAT), immunological risk and potential renal benefit.
Salvatore Di Maria, Carmelo Puglia, Alessio Provenzani   +2 more
wiley   +1 more source

Heuristic Fuzzy Approach to Traffic Flow Modelling and Control on Urban Networks

Future Internet
Computer-aided transport modelling is essential for testing different control strategies for traffic lights. One approach to modelling traffic control is by heuristically defining fuzzy rules for the control of traffic light systems and applying them to ...
Alexander Gegov, Boriana Vatchova, Yordanka Boneva, Alexandar Ichtev   +3 more
doaj   +1 more source

Simulating family life courses: An application for Italy, Great Britain, Norway, and Sweden

Demographic Research, 2021
Background: Family patterns in Western countries have changed substantially across birth cohorts. The spread of unmarried cohabitation, the decline and postponement of marriage and fertility, and the rise in nonmarital births, partnership instability ...
Maria Winkler-Dworak, Eva Beaujouan, Paola Di Giulio, Martin Spielauer   +3 more
doaj   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source