Results 1 to 10 of about 6,917 (192)

Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
BackgroundHepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH).
Jian-Hong Zhong, Bang-De Xiang, Liang Ma, Xue-Mei You, Le-Qun Li, Gui-Sheng Xie   +5 more
doaj   +4 more sources

Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes [PDF]

International Journal of COPD, 2015
Jian-Qing Zhang,1 Jia-Qiang Zhang,1 Hua Liu,2 Zhi-Huan Zhao,1 Li-Zhou Fang,1 Ling Liu,1 Wei-Ping Fu,1 Jing-Kui Shu,1 Jia-Gang Feng,1 Lu-Ming Dai1 1Department of Respiratory Critical Care Medicine, 2Department of Clinical Laboratory, First Affiliated ...
Zhang JQ, Zhang JQ, Liu H, Zhao ZH, Fang LZ, Liu L, Fu WP, Shu JK, Feng JG, Dai LM   +9 more
doaj   +3 more sources

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. [PDF]

PLoS ONE, 2015
Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in the metabolism of numerous xenobiotics as well as mediating the sodium-dependent transport of bile acids into hepatocytes.
Hui Peng, Qin-shi Zhu, Shuping Zhong, Daniel Levy   +3 more
doaj   +4 more sources

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol [PDF]

Journal of Lipid Research, 2014
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom, Michael P. Endsley, Adam W. Pfeiffer, John R. Falck, William B. Campbell   +4 more
doaj   +2 more sources

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury [PDF]

Frontiers in Pharmacology
Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide
Niklas Larsson, Cindy B. McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind, Anders Brolin, Martin Isaksson Mettävainio, Bruce D. Hammock, Christophe Morisseau, Malin L. Nording, Malin L. Nording   +15 more
doaj   +2 more sources

Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase-derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Type 2 diabetes mellitus (T2DM) is a risk factor for dementia and cerebral small vessel disease, but there remains a need to identify targetable molecular pathways involved in the underlying pathophysiology. METHODS In participants with Alzheimer's disease, related dementias, or cerebrovascular diseases, we assessed associations ...
Ryoo SW, Lin WZ, Magliocco A, Ruthirakuhan M, Wong YY, Perfetto SE, Huang C, Anita NZ, Arnott SR, Lang AE, Symons S, Hegele RA, Goubran M, Ramirez J, Ottoy J, Rabin JS, MacIntosh BJ, Lanctôt KL, Liang N, Cogo-Moreira H, Taha AY, Swardfager W, ONDRI Investigators.   +22 more
europepmc   +2 more sources

5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates. [PDF]

Arch Pharm (Weinheim)
5‐Methyl‐2‐carboxamidepyrrole‐based compounds were disclosed as new microsomal prostaglandin E2 synthase‐1 (mPGES‐1)/soluble epoxide hydrolase (sEH) inhibitors, highlighting their promising profile as anticancer agents. A combined in silico/experimental approach is reported, highlighting its applicability for discovering novel bioactive compounds ...
Colarusso E, Lauro G, Potenza M, Galatello P, Garigliota MLD, Ferraro MG, Piccolo M, Chini MG, Irace C, Campiglia P, Hoffstetter RK, Werz O, Ramunno A, Bifulco G.   +13 more
europepmc   +2 more sources

The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase. [PDF]

Int J Mol Sci, 2023
He Q, McCoy MR, Qi M, Morisseau C, Yang H, Xu C, Shey R, Goodman MC, Zhao S, Hammock BD.   +9 more
europepmc   +3 more sources

Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. [PDF]

Toxicol Lett, 2016
Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS.   +4 more
europepmc   +2 more sources

Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence. [PDF]

Mol Biol Int, 2013
Aydin A, Pinarbasi H, Gurelik M.
europepmc   +3 more sources