Regulation of cardiovascular biology by microsomal epoxide hydrolase. [PDF]
Toxicol Res, 2021 Microsomal epoxide hydrolase/epoxide hydrolase 1 (mEH/EPHX1) works in conjunction with cytochromes P450 to metabolize a variety of compounds, including xenobiotics, pharmaceuticals and endogenous lipids. mEH has been most widely studied for its role in metabolism of xenobiotic and pharmaceutical compounds where it converts hydrophobic and reactive ...
Edin ML, Zeldin DC.
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Development of potent inhibitors of the human microsomal epoxide hydrolase. [PDF]
Eur J Med Chem, 2020 Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing molecules. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of some diseases. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more
Barnych B +11 more
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Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma. [PDF]
PLoS ONE, 2013 BackgroundHepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH).
Jian-Hong Zhong +5 more
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The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase. [PDF]
Int J Mol Sci, 2023 A microsomal epoxide hydrolase (mEH) metabolizes in vivo in both xenobiotic and endogenous epoxides associated with signaling function. Findings in patients suggest that mEH might be a biomarker for several diseases, including metastatic cancer and viral hepatitis.
He Q +9 more
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Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. [PDF]
Toxicol Lett, 2016 Naphthalene (NA) is a ubiquitous pollutant to which humans are widely exposed. 1,2-Dihydro-1,2-dihydroxynaphthalene (NA-dihydrodiol) is a major metabolite of NA generated by microsomal epoxide hydrolase (mEH). To investigate the role of the NA-dihydrodiol and subsequent metabolites (i.e.
Carratt SA +4 more
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A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol [PDF]
Journal of Lipid Research, 2014 Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom +4 more
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Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes [PDF]
International Journal of COPD, 2015 Jian-Qing Zhang,1 Jia-Qiang Zhang,1 Hua Liu,2 Zhi-Huan Zhao,1 Li-Zhou Fang,1 Ling Liu,1 Wei-Ping Fu,1 Jing-Kui Shu,1 Jia-Gang Feng,1 Lu-Ming Dai1 1Department of Respiratory Critical Care Medicine, 2Department of Clinical Laboratory, First Affiliated ...
Zhang JQ +9 more
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Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. [PDF]
Journal of Biological Chemistry, 1980 Hepatic microsomal epoxide hydrolase activity (EC 3.3.2.3), assayed using styrene oxide as the substrate, has a pH optimum of 9.5 from C57BL/6J mice and a pH optimum of 8.7 from DBA/2J mice. In cross and back-cross matings between C57BL/6J and DBA/2J mice, this phenotypic difference in epoxide hydrolase activity is inherited as a single autosomal trait,
Stewart D. Lyman +2 more
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Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD [PDF]
International Journal of Molecular Medicine, 2005 Although smoking is the major causal factor in the development of chronic obstructive pulmonary disease (COPD), only 10-20% of chronic heavy cigarette smokers develop symptomatic COPD, which suggests the presence of genetic susceptibility. The human microsomal epoxide hydrolase (EH) is a metabolizing enzyme which involves the process of numerous ...
Jong Moon Park +3 more
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A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia [PDF]
Journal of Medical Genetics, 2001 Microsomal epoxide hydrolase is an important enzyme involved in the metabolism of endogenous and exogenous toxicants. Polymorphic variants of the human epoxide hydrolase gene vary in enzyme activity. We determined whether genetic variability in the gene encoding for microsomal epoxide hydrolase contributes to individual differences in susceptibility to
Petra L.M. Zusterzeel
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