Results 161 to 170 of about 2,725 (177)
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Induction of microsomal epoxide hydrolase by tienilic acid in the rat
Journal of Applied Toxicology, 1983AbstractThe effects of tienilic acid [2,3‐dichloro‐4‐(2‐thienylcarbonyl)phenoxy acetic acid] on drug‐metabolizing enzymes in the rat liver and kidneys were studied. Short‐term treatment for 2 weeks (450 mg per kg per day) increased the activity of microsomal epoxide hydrolase at least two‐fold in both rat liver and kidneys.
R. Sellman, M. G. Parkki
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Interaction of epoxide hydrolase with itself and other microsomal proteins
Archives of Biochemistry and Biophysics, 1982Abstract The interactions of rat liver epoxide hydrolase (EC 3.3.2.3) with itself and with cytochromes P-450 and NADPH-cytochrome P-450 reductase were investigated in microsomal preparations and in reconstituted systems in which all of the enzymes are functionally active.
F. Peter Guengerich, Nancy K. Davidson
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Purification and Characterization of Dog Liver Microsomal Epoxide Hydrolase
The Journal of Biochemistry, 1994An epoxide hydrolase (mEH) in liver microsomes was purified to apparent homogeneity from a dog treated with phenobarbital. The purified enzyme had a minimum molecular weight of 47,000 as determined by SDS-PAGE. The dog mEH activity was characterized by use of a substrate, 7-glycidoxycoumarin (GOC), and some effectors of this enzyme. In vitro activators,
Yuji Ishii +3 more
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Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer
Head & Neck, 2008AbstractBackground.Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke. We investigated whether functional genetic polymorphisms in mEH may have a risk‐modifying effect on head and neck carcinogenesis.Methods.Blood from 429 patients with oral, pharyngeal, and laryngeal carcinoma and 419 ...
Lacko, M. +6 more
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Fish Physiology and Biochemistry, 1996
Epoxide hydrolase of microsomal membranes of the common dab (Limanda limanda) has been characterized using p-nitrostyrene oxide as substrate. Under the conditions of assay used, the turnover number with this substrate was higher than found for the more frequently used styrene oxide and steady state kinetics were observed. The enzyme had a KM of 0.12 mM
Nicola Dunlop +3 more
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Epoxide hydrolase of microsomal membranes of the common dab (Limanda limanda) has been characterized using p-nitrostyrene oxide as substrate. Under the conditions of assay used, the turnover number with this substrate was higher than found for the more frequently used styrene oxide and steady state kinetics were observed. The enzyme had a KM of 0.12 mM
Nicola Dunlop +3 more
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Toxicology and Applied Pharmacology, 1983
Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrolase activity with benzo(a)pyrene, 4 ...
Bruce D. Hammock, Kenji Ota
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Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrolase activity with benzo(a)pyrene, 4 ...
Bruce D. Hammock, Kenji Ota
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Microsomal Epoxide Hydrolase Is Not Associated with COPD in a Community-Based Sample
Human Biology, 2006Microsomal epoxide hydrolase (EPHX1) is an important gene because of its role in the metabolism of components of cigarette smoke; thus it may be an important potential modifier of the risk of developing smoking-related lung disease, such as chronic obstructive pulmonary disease (COPD). Several studies have investigated EPHX1 and COPD, but some of these
Matheson, Melanie C +4 more
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Expression of rat microsomal epoxide hydrolase during pregnancy
Biochemical Pharmacology, 1995Microsomal epoxide hydrolase (mEH) protein and messenger ribonucleic acid (mRNA) levels were assessed in maternal rats during pregnancy and mEH gene expression was compared with cytochrome P450 expression. Immunoblot analysis using goat anti-rat mEH antibody showed that hepatic mEH levels in adult rats at day 12 of gestation were comparable to those in
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Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer
Molecular Carcinogenesis, 1996Microsomal epoxide hydrolase (EPHX) is one of many enzymes involved in the metabolism of endogenous and exogenous toxicants. Polymorphic forms of the human EPHX gene have been described that vary in enzymatic activity, and one, Tyr113His, has been associated with hepatocellular carcinoma susceptibility. We demonstrated that EPHX was highly expressed in
Andrew Berchuck +7 more
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Journal of the Chemical Society, Chemical Communications, 1989
1,2-Epoxycycloalkanes from C5 to C8 and cis-stilbene oxide are respectively hydrolysed to the corresponding (–)-(R,R)-trans-diols and to (+)-(R,R)-1,2-diphenylethane-1,2-diol by both the microsomal and the cytosolic epoxide hydrolase of rabbit liver, the former enzyme being more active and giving higher enantiomeric excesses.
BELLUCCI G +3 more
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1,2-Epoxycycloalkanes from C5 to C8 and cis-stilbene oxide are respectively hydrolysed to the corresponding (–)-(R,R)-trans-diols and to (+)-(R,R)-1,2-diphenylethane-1,2-diol by both the microsomal and the cytosolic epoxide hydrolase of rabbit liver, the former enzyme being more active and giving higher enantiomeric excesses.
BELLUCCI G +3 more
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