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Genetic Variants in Microsomal Epoxide Hydrolase Influence Carbamazepine Dosing
Clinical Neuropharmacology, 2009The dose of carbamazepine required to achieve optimal seizure control varies widely from patient to patient. We investigated polymorphic variants in various genes involved in the pharmacokinetics and pharmacodynamics of carbamazepine in an effort to identify predictors of maintenance dose.: A total of 70 patients with epilepsy (49% were males; median ...
Elaine A. Wilson +6 more
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Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase
Chemical Research in Toxicology, 2008The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of xenobiotics such as polyaromatic toxicants. Additionally, polymorphism studies have underlined a potential role of this enzyme in relation to a number of diseases, such as emphysema, spontaneous abortion, eclampsia, and several forms of cancer. We recently demonstrated
Dexter Morin +6 more
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Selective inhibition and selective induction of multiple microsomal epoxide hydrolases
Biochemical Pharmacology, 1986The inhibition in vitro and induction in vivo of microsomal trans-stilbene oxide hydrolase have been studied. This microsomal epoxide hydrolase activity is distinguishable from the previously well-defined microsomal arene oxide hydrolase by a number of catalytic criteria.
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Microsomal epoxide hydrolase properties, regulation and function
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1983Joseph W. DePierre, Janeric Seidegård
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Metabolism and Toxicity of Styrene in Microsomal Epoxide Hydrolase-Deficient Mice
Journal of Toxicology and Environmental Health, Part A, 2010Styrene, which is widely used in manufacturing, is both acutely and chronically toxic to mice. Styrene is metabolized by cytochromes P-450 to the toxic metabolite styrene oxide, which is detoxified via hydrolysis with microsomal epoxide hydrolase (mEH) playing a major role. The purpose of these studies was to characterize the importance of this pathway
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Polymorphism in gene for microsomal epoxide hydrolase and lung disease [PDF]
The Lancet, 1997 Neil R. Kitteringham +2 more
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