Results 21 to 30 of about 6,917 (192)

Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region. [PDF]

RNA, 2013
Nguyen HL, Yang X, Omiecinski CJ.
europepmc   +3 more sources

Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene

Frontiers in Pharmacology, 2023
Introduction: In clinical practice, warfarin is often combined with Compound Danshen dripping pill (CDDP) for the treatment of cardiovascular diseases.
Xixi Chen, Xixi Chen, Xurui Zuo, Yingqiang Zhao, Yuhong Huang, Chunxiao Lv   +5 more
doaj   +1 more source

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

Pharmaceuticals, 2021
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids.
Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez   +8 more
doaj   +1 more source

Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers

Scientific Reports, 2021
Over the last decade oxylipins have become more recognized for their involvement in several diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to inhibit cyclooxygenase (COX) enzymes, but how NSAIDs affect oxylipins, in ...
Shuchita Tiwari, Jun Yang, Christophe Morisseau, Blythe Durbin-Johnson, Bruce D. Hammock, Aldrin V. Gomes   +5 more
doaj   +1 more source

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

Journal of Lipid Research, 1974
The formation of 5α,6α- and 5β,6β-epoxides of cholesterol and β-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols ...
Leif Aringer, Peter Eneroth
doaj   +1 more source

Primary Structure and Catalytic Mechanism of the Epoxide Hydrolase from Agrobacterium radiobacter AD1 [PDF]

, 1997
The epoxide hydrolase gene from Agrobacterium radiobacter AD1, a bacterium that is able to grow on epichlorohydrin as the sole carbon source, was cloned by means of the polymerase chain reaction with two degenerate primers based on the N-terminal and C ...
Altschul, Andrade, Arand, Arand, Armstrong, Ausubel, Beetham, Beetham, Bell, Burley, Dick B. Janssen, Dı́az, Falany, Fujio, Geourjon, Grant, Hassett, Hecht, Heidelbach, Innis, Itzhaki, Jacobs, Janssen, Janssen, Johnson, Kawasaki, Kiyosue, Knehr, Kunkel, Lacourciere, Loewenthal, Marko Fennema, Mehta, Miller, Minke Smids, Noble, Ollis, Pries, Provencher, Rick Rink, Rost, Sambrook, Sanger, Schanstra, Skoda, Solovyev, Sreerama, Stapleton, Studier, Thomas, Thompson, Uwe Dehmel, Van den Wijngaard, Verschueren, Verschueren, Wang, Wilson, Winkler, Wojtasek, Yanisch-Perron   +59 more
core   +3 more sources

Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. [PDF]

PLoS ONE, 2016
UNLABELLED:We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). Endoplasmic reticulum (
Fang Yang, Hong Yang, Aramandla Ramesh, J Shawn Goodwin, Emmanuel U Okoro, ZhongMao Guo   +5 more
doaj   +1 more source

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition

European Journal of Medicinal Chemistry Reports, 2022
Here we report the application of a multi-disciplinary protocol for investigating thiazolidin-4-one-based compounds as new promising anti-inflammatory agents interfering with the eicosanoid biosynthesis pathways.
Ester Colarusso, Marianna Potenza, Gianluigi Lauro, Maria Giovanna Chini, Valentina Sepe, Angela Zampella, Katrin Fischer, Robert K. Hofstetter, Oliver Werz, Giuseppe Bifulco   +9 more
doaj   +1 more source