Results 21 to 30 of about 2,725 (177)

Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene

Frontiers in Pharmacology, 2023
Introduction: In clinical practice, warfarin is often combined with Compound Danshen dripping pill (CDDP) for the treatment of cardiovascular diseases.
Xixi Chen, Xixi Chen, Xurui Zuo, Yingqiang Zhao, Yuhong Huang, Chunxiao Lv   +5 more
doaj   +1 more source

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

Pharmaceuticals, 2021
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids.
Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez   +8 more
doaj   +1 more source

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source

Oxetane Substrates of Human Microsomal Epoxide Hydrolase [PDF]

Drug Metabolism and Disposition, 2017
Oxetanyl building blocks are increasingly used in drug discovery because of the improved drug-like properties they confer on drug candidates, yet little is currently known about their biotransformation. A series of oxetane-containing analogs was studied and we provide the first direct evidence of oxetane hydrolysis by human recombinant microsomal ...
Anders Johansson, Francesca Toselli, Lars Weidolf, Martin A. Hayes, Peder Svensson, Marlene Fredenwall, Xue-Qing Li   +6 more
openaire   +2 more sources

Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers

Scientific Reports, 2021
Over the last decade oxylipins have become more recognized for their involvement in several diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to inhibit cyclooxygenase (COX) enzymes, but how NSAIDs affect oxylipins, in ...
Shuchita Tiwari, Jun Yang, Christophe Morisseau, Blythe Durbin-Johnson, Bruce D. Hammock, Aldrin V. Gomes   +5 more
doaj   +1 more source

Targeted Disruption of the Microsomal Epoxide Hydrolase Gene [PDF]

Journal of Biological Chemistry, 1999
Microsomal epoxide hydrolase (mEH) is a conserved enzyme that is known to hydrolyze many drugs and carcinogens, and a few endogenous steroids and bile acids. mEH-null mice were produced and found to be fertile and have no phenotypic abnormalities thus indicating that mEH is not critical for reproduction and physiological homeostasis.
Shioko Kimura, Gen Kudo, Pedro M. Fernández-Salguero, Frank J. Gonzalez, Harry V. Gelboin, Ying-Hue Lee, Tian J. Yang, Masaaki Miyata   +7 more
openaire   +3 more sources

Visualization of a Covalent Intermediate between Microsomal Epoxide Hydrolase, but not Cholesterol Epoxide Hydrolase, and their Substrates [PDF]

European Journal of Biochemistry, 1997
Mammalian soluble and microsomal epoxide hydrolases have been proposed to belong to the family of αlβ‐hydrolase‐fold enzymes. These enzymes hydrolyse their substrates by a catalytic triad, with the first step of the enzymatic reaction being the formation of a covalent enzyme‐substrate ester. In the present paper, we describe the direct visualization of
Müller, F, Arand, Michael, Frank, H, Seidel, A, Hinz, W, Winkler, L, Hänel, K, Blée, E, Beetham, J K, Hammock, B D, Oesch, F   +10 more
openaire   +3 more sources

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Microsomal epoxide hydrolase polymorphisms

Molecular Medicine Reports, 2010
Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively.
Pinarbasi, Hatice, Silig, Yavuz, Pinarbasi, Ergun   +2 more
openaire   +6 more sources

Microsomal epoxide hydrolase genotype and risk of myocardial infarction [PDF]

Archives of Toxicology, 2007
DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). Microsomal epoxide hydrolase (EPHX1) is involved in the metabolism of tobacco smoke mutagens and an amino acid substitution (H139R) in exon 4 of the EPHX1 gene is associated with increased enzyme activity.
Ahmed El-Sohemy, Hannia Campos, Hannia Campos, Marilyn C. Cornelis   +3 more
openaire   +4 more sources