Results 31 to 40 of about 2,725 (177)
Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. [PDF]
PLoS ONE, 2016 UNLABELLED:We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). Endoplasmic reticulum (
Fang Yang +5 more
doaj +1 more source
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. [PDF]
Thorax, 2007 Salam MT +4 more
europepmc +3 more sources
Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine
Frontiers in Veterinary Science, 2020 The veterinary pharmacopeia available to treat pain and inflammation is limited in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs being tested ...
Diyala S. Shihadih +11 more
doaj +1 more source
Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome
Case Reports in Medicine, 2018 Lamotrigine (LTG) is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain.
Marta Vázquez +6 more
doaj +1 more source
Journal of the Formosan Medical Association, 2011 Microsomal epoxide hydrolase (EPHX) is an important enzyme that metabolizes harmful reactive epoxides from smoking. Genetic variations of this enzyme are thought to increase the risk of developing chronic obstructive pulmonary disease (COPD).
Chiung-Zuei Chen +5 more
doaj +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2015 Background: Gene polymorphisms and COPD susceptibility have been paid special attention and were explored in a large number of studies. The results varied between studies and populations.
Rabab A. El Wahsh +4 more
doaj +1 more source
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. [PDF]
PLoS ONE, 2009 Polymorphisms in genes coding for enzymes that activate tobacco lung carcinogens may generate inter-individual differences in lung cancer risk. Previous studies had limited sample sizes, poor exposure characterization, and a few single nucleotide ...
Melissa Rotunno +16 more
doaj +1 more source
Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk. [PDF]
PLoS ONE, 2012 BACKGROUND: Microsomal epoxide hydrolase (EPHX1) plays an important role in both the activation and detoxification of PAHs, which are carcinogens found in cooked meat and tobacco smoking.
Fei Liu +8 more
doaj +1 more source
Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children
Zdorovʹe Rebenka, 2012 The phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied.
L.Ya. Lytvynets +3 more
doaj +1 more source
Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy. [PDF]
British Journal of Clinical Pharmacology, 1994 1. In order to determine whether carbamazepine is an inducer of lymphocyte microsomal epoxide hydrolase, the activity of the enzyme has been measured in the lymphocytes of 40 patients on continuous drug therapy using [3H]‐cis stilbene oxide as a substrate. 2.
Munir Pirmohamed +5 more
openaire +3 more sources