Results 31 to 40 of about 6,917 (192)

Dataset from proteomic analysis of human liver, lung, kidney and intestine microsomes

Data in Brief, 2018
We provide detailed datasets from our analysis of proteins that are identified in human liver, lung, kidney and intestine microsomes by MS-based proteomics.
Wei Song, Longjiang Yu, Zhihong Peng
doaj   +1 more source

Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients [PDF]

, 2014
BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the ...
AGNELLO, Luisa, BAZZA, Federica, BELLIA, Chiara, BIVONA, Giulia, CARUSO, Antonietta, CIACCIO, Marcello, LO SASSO, Bruna, Pivetti, A, SCAZZONE, Concetta   +8 more
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Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]

, 2019
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska, Enghard, Philipp, Gollasch, Maik, Hammock, Bruce D., Klocke, Jan, Riemekasten, Gabriela, Rudolph, Birgit, Schunck, Wolf-Hagen, Ulu, Arzu, Wu, Kaiyin   +9 more
core   +2 more sources

Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine

Frontiers in Veterinary Science, 2020
The veterinary pharmacopeia available to treat pain and inflammation is limited in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs being tested ...
Diyala S. Shihadih, Todd R. Harris, Sean D. Kodani, Sung-Hee Hwang, Kin Sing Stephen Lee, Kin Sing Stephen Lee, Vengai Mavangira, Briana Hamamoto, Alonso Guedes, Alonso Guedes, Bruce D. Hammock, Christophe Morisseau   +11 more
doaj   +1 more source

Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome

Case Reports in Medicine, 2018
Lamotrigine (LTG) is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain.
Marta Vázquez, Cecilia Maldonado, Natalia Guevara, Andrea Rey, Pietro Fagiolino, Antonella Carozzi, Carlos Azambuja   +6 more
doaj   +1 more source

Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice [PDF]

, 2017
We recently generated glutathione S-transferase (GST) A3 knockout (KO) mice as a novel model to study the risk factors for liver cancer. GSTA3 KO mice are sensitive to the acute cytotoxic and genotoxic effects of aflatoxin B1 (AFB1), confirming the ...
Crawford, Dana R., Ilic, Zoran, Guest, Ian, Milne, Ginger L., Hayes, John D., Sell, Stewart   +5 more
core   +5 more sources

A single meal has the potential to alter brain oxylipin content. [PDF]

, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH, Norman, JE, Otoki, Y, Rutledge, JC, Taha, AY, Zhang, Z   +5 more
core   +1 more source

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function

Journal of Lipid Research, 2018
Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi, William E. Boeglin, Christophe Morisseau, Robert W. Davis, Gary A. Sulikowski, Bruce D. Hammock, Alan R. Brash   +6 more
doaj   +1 more source

Evidence for the role of EPHX2 gene variants in anorexia nervosa. [PDF]

, 2013
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants.
Bansal, V, Berenson, G, Bergen, AW, Berrettini, W, Bloss, CS, Brandt, H, Bulik, CM, Carson, A, Chen, W, Crawford, S, Crow, S, Darst, BF, Duvvuri, V, Fichter, MM, Galvez, L, Halmi, KA, Johnson, C, Kaplan, AS, Kaye, W, Keel, P, Klump, KL, La Via, M, Levy, S, Libiger, O, Lilenfeld, L, Magistretti, P, Mitchell, JE, Murray, S, Pham, P, Phillips, T, Plotnicov, K, Rotondo, A, Schork, NJ, Scott-Van Zeeland, AA, Shih, PB, Smith, EN, Srinivasan, S, Strober, M, Tewhey, R, Tisch, R, Topol, EJ, Torkamani, A, Treasure, J, Villarasa, N, Wineinger, N, Woodside, DB, Zhang, G   +46 more
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Polymorphism of microsomal epoxide hydrolase is associated with chronic obstructive pulmonary disease and bronchodilator response

Journal of the Formosan Medical Association, 2011
Microsomal epoxide hydrolase (EPHX) is an important enzyme that metabolizes harmful reactive epoxides from smoking. Genetic variations of this enzyme are thought to increase the risk of developing chronic obstructive pulmonary disease (COPD).
Chiung-Zuei Chen, Ru-Hsueh Wang, Cheng-Hung Lee, Chien-Chung Lin, Han-Yu Chang, Tzuen-Ren Hsiue   +5 more
doaj   +1 more source