Results 41 to 50 of about 6,917 (192)

Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. [PDF]

PLoS ONE, 2009
Polymorphisms in genes coding for enzymes that activate tobacco lung carcinogens may generate inter-individual differences in lung cancer risk. Previous studies had limited sample sizes, poor exposure characterization, and a few single nucleotide ...
Melissa Rotunno, Kai Yu, Jay H Lubin, Dario Consonni, Angela C Pesatori, Alisa M Goldstein, Lynn R Goldin, Sholom Wacholder, Robert Welch, Laurie Burdette, Stephen J Chanock, Pier Alberto Bertazzi, Margaret A Tucker, Neil E Caporaso, Nilanjan Chatterjee, Andrew W Bergen, Maria Teresa Landi   +16 more
doaj   +1 more source

GSTM1, GSTT1 and EPHX1 gene polymorphisms and susceptibility to COPD in a sample of Egyptian population

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: Gene polymorphisms and COPD susceptibility have been paid special attention and were explored in a large number of studies. The results varied between studies and populations.
Rabab A. El Wahsh, Enas S. Essa, Ramadan M. Bakr, Mohamed A. Zamzam, Shimaa M. Abozeid   +4 more
doaj   +1 more source

Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children

Zdorovʹe Rebenka, 2012
The phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied.
L.Ya. Lytvynets, O.B. Synoverska, O.Z. Gnateyko, N.V. Vyshtak   +3 more
doaj   +1 more source

Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids[S]

Journal of Lipid Research, 2019
A chiral lipidomics approach was established for comprehensive profiling of regio- and stereoisomeric monoepoxy and monohydroxy metabolites of long-chain PUFAs as generated enzymatically by cytochromes P450 (CYPs), lipoxygenases (LOXs), and ...
Maximilian Blum, Inci Dogan, Mirjam Karber, Michael Rothe, Wolf-Hagen Schunck   +4 more
doaj   +1 more source

Aryl Hydrocarbon Hydroxylase, Epoxide Hydrolase, and Benzo[a]pyrene Metabolism in Human Epidermis: Comparative Studies in Normal Subjects and Patients with Psoriasis [PDF]

, 1984
Prior studies have shown that human skin possesses a cytochrome P-450-dependent microsomal enzyme that is capable of metabolizing drugs and polycyclic aromatic hydrocarbon (PAH) carcinogens.
David R. Bickers, Hasan Mukhtar, Tapu Dutta-Choudhury, Cynthia L. Marcelo, John J. Voorhees, Blum, Hueper, Bickers, Miller, Heidelberger, Gelboin, Daudel, Levin, Koreeda, Alvares, Bickers, Oesch, Nebert, Nebert, Chapman, Shuster, Stern, Rawlins, Finnen, Voorhees, Nebert, Mukhtar, Lowry, Bickers, Bickers, Chapman, Chapman, Shuster, Pott, Blum, Henry, Harber, Goeckerman, Kellermann, Paigen, McLemore, Prasad, Fletcher, Paigen, Jett, Ruzicka, Karki   +46 more
core   +6 more sources

Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Pharmaceuticals, 2017
Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate.
Natalia Guevara, Cecilia Maldonado, Manuel Uría, Raquel González, Manuel Ibarra, Silvana Alvariza, Antonella Carozzi, Carlos Azambuja, Pietro Fagiolino, Marta Vázquez   +9 more
doaj   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, Volume 118, Issue 3, Page 682-692, September 2025.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study

Frontiers in Oncology, 2012
Background:The countries of Central and Eastern Europe have among the highest worldwide rates of renal cell cancer. Few studies have examined whether genetic variation in xenobiotic metabolic pathway genes may modify risk for this cancer.
Julia E. Heck, Julia E. Heck, Lee eMoore, Yuan-Chin Amy eLee, James eMcKay, Rayjean eHung, Sara eKarami, Valérie eGaborieau, Neonila eSzeszenia-Dabrowska, David eZaridze, Anush eMukeriya, Dana eMates, Lenka eForetova, Vladimir eJanout, Helena eKollárová, Vladimir eBencko, Nathaniel eRothman, Paul eBrennan, Wong-Ho eChow, Paolo eBoffetta   +19 more
doaj   +1 more source

Toxicological Response of the BEAS‐2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m‐Xylene Alone and in Binary Mixtures

Journal of Applied Toxicology, Volume 45, Issue 9, Page 1770-1786, September 2025.
ABSTRACT Benzene, toluene, ethylbenzene, and xylenes (o‐, m‐, and p‐xylenes) constitute a family, named BTEX, of volatile organic compounds (VOCs) known for its toxicity. This study aimed to study the acute in vitro toxicity of ethylbenzene and m‐xylene on human bronchial epithelial cells exposed at the air–liquid interface (ALI).
Nour Jaber, Claude Emond, Fabrice Cazier, Sylvain Billet   +3 more
wiley   +1 more source

GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD [PDF]

, 2014
The aim of this study was to test the hypothesis that glutathione-S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian ...
Dodig, Slavica, Petlevski, Roberta, Popović-Grle, Sanja, Žuntar, Irena   +3 more
core   +4 more sources