Results 41 to 50 of about 2,725 (177)

Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Pharmaceuticals, 2017
Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate.
Natalia Guevara, Cecilia Maldonado, Manuel Uría, Raquel González, Manuel Ibarra, Silvana Alvariza, Antonella Carozzi, Carlos Azambuja, Pietro Fagiolino, Marta Vázquez   +9 more
doaj   +1 more source

Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study

Frontiers in Oncology, 2012
Background:The countries of Central and Eastern Europe have among the highest worldwide rates of renal cell cancer. Few studies have examined whether genetic variation in xenobiotic metabolic pathway genes may modify risk for this cancer.
Julia E. Heck, Julia E. Heck, Lee eMoore, Yuan-Chin Amy eLee, James eMcKay, Rayjean eHung, Sara eKarami, Valérie eGaborieau, Neonila eSzeszenia-Dabrowska, David eZaridze, Anush eMukeriya, Dana eMates, Lenka eForetova, Vladimir eJanout, Helena eKollárová, Vladimir eBencko, Nathaniel eRothman, Paul eBrennan, Wong-Ho eChow, Paolo eBoffetta   +19 more
doaj   +1 more source

Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer [PDF]

British Journal of Cancer, 1998
We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0).
C A D Smith, Andrew H. Wyllie, A. L. Hubbard, J MacMillan, David J. Harrison   +4 more
openaire   +3 more sources

The Chicken Egg Genotoxicity Assay (CEGA): Assessing Target Tissue Exposure and Metabolism in the Embryo‐Fetal Chicken Livers

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar, T. Kobets, Anne Marie Api, J. D. Duan, G. M. Williams   +4 more
wiley   +1 more source

Toxicological Response of the BEAS‐2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m‐Xylene Alone and in Binary Mixtures

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzene, toluene, ethylbenzene, and xylenes (o‐, m‐, and p‐xylenes) constitute a family, named BTEX, of volatile organic compounds (VOCs) known for its toxicity. This study aimed to study the acute in vitro toxicity of ethylbenzene and m‐xylene on human bronchial epithelial cells exposed at the air–liquid interface (ALI).
Nour Jaber, Claude Emond, Fabrice Cazier, Sylvain Billet   +3 more
wiley   +1 more source

Reversible Neonatal Cholestasis Following In Utero Exposure to Valproic Acid

McGill Journal of Medicine, 2020
Valproic acid (VPA) is a branched-chain carboxylic acid with broad anticonvulsant activity. Its spectrum of activity is thought to be mediated by combined molecular effects on intercellular Na+ currents, neuron K+ channels, and inhibition of gamma ...
Douglas G Chang, Martin Stein, David Sine, David Yeung, Frank Mannino   +4 more
doaj   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population

Neuropsychiatric Disease and Treatment, 2021
Birsen Can Demirdöğen,1 Yağmur Miçooğulları,2 Aysun Türkanoğlu Özçelik,3 Orhan Adalı4 1Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey; 2Institute of Natural and Applied ...
Can Demirdöğen B, Miçooğulları Y, Türkanoğlu Özçelik A, Adalı O   +3 more
doaj  

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Discovery of the First‐in‐Class Inhibitors of Hypoxia Up‐Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation

Angewandte Chemie, Volume 136, Issue 14, April 2, 2024.
A multidisciplinary pipeline consisting of medicinal chemistry, molecular phenotyping, chemoproteomics, RNA‐sequencing, short hairpin RNAs (shRNAs)‐mediated gene silencing and in vivo studies led to a novel series of compounds suppressing pathogenic fibroblast activation via Hypoxia up‐regulated protein 1 (HYOU1) inhibition.
Dimitra Papadopoulou, Vasiliki Mavrikaki, Filippos Charalampous, Christos Tzaferis, Martina Samiotaki, Konstantinos D. Papavasileiou, Antreas Afantitis, Niki Karagianni, Maria C. Denis, Julie Sanchez, J. Robert Lane, Zacharias Faidon Brotzakis, Georgios Skretas, Dimitris Georgiadis, Alexios N. Matralis, George Kollias   +15 more
wiley   +2 more sources