Results 61 to 70 of about 6,917 (192)

Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD)

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Dissecting the pathophysiological role of Leukotrienes in the lung–gut axis: A potential mediator of the asthma–IBD crosstalk. ABSTRACT Leukotrienes are potent inflammatory lipid mediators produced primarily by immune cells. Inflammation, being the center stone of two major disease conditions, namely, asthma and inflammatory bowel disease (IBD), has ...
Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K. Thodeti, Sailaja Paruchuri   +4 more
wiley   +1 more source

Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences [PDF]

, 2017
Activities of microsomal monooxygenases (MO) and epoxide hydrolase (EH) and cytoplasmic glutathione-S-transferases (GST) will contribute to controlling the pool of reactive intermediates, enzymatically derived from polynuclear aromatic hydrocarbons (PAH)
Althaus, Ulrich, Lorenz, Joachim, Oesch, Franz, Ohnhaus, Edgar, Schmassmann, Hansueli   +4 more
core  

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

Medicines, 2016
Background: Traditional Chinese Medicine (TCM) with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products.
Rolf Teschke, Dominique Larrey, Dieter Melchart, Gaby Danan   +3 more
doaj   +1 more source

The Chicken Egg Genotoxicity Assay (CEGA): Assessing Target Tissue Exposure and Metabolism in the Embryo‐Fetal Chicken Livers

Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 243-257, June 2025.
ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar, T. Kobets, Anne Marie Api, J. D. Duan, G. M. Williams   +4 more
wiley   +1 more source

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices [PDF]

, 2017
The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of
Ioannides, C, Plant, KE, Plant, NJ, Pushparajah, DS   +3 more
core   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery

Respiratory Research, 2007
Background In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability.
DeMeo Dawn L, Hersh Craig P, Reilly John J, Silverman Edwin K   +3 more
doaj   +1 more source

TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1‐Mediated Arachidonic Acid Metabolism

Advanced Science, Volume 12, Issue 8, February 24, 2025.
This study integrates multi‐omics to reveal TRIM21's pivotal role in pancreatic cancer development and resistance to gemcitabine. TRIM21 promotes ubiquitin‐mediated degradation of EPHX1 at the K105 site, which in turn inhibits arachidonic acid metabolism. Bezafibrate sensitizes gemcitabine sensitivity by inhibiting the TRIM21‐EPHX1 interaction and is a
Xiaona Fan, Yisheng Dai, Chuanfeng Mo, Hengzhen Li, Xindi Luan, Bojun Wang, Jiani Yang, Guangtao Jiao, XiaoLin Lu, Zhuo Chen, Yuanyu Liao, Ling Qu, Huike Yang, Changjie Lou, Chao Liu, Zhiwei Li   +15 more
wiley   +1 more source

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling [PDF]

, 2018
Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the classification of epoxide hydrolases as typical detoxifying enzymes.
Arand, Michael, Cronin, Annette, Decker, Martina   +2 more
core