Results 61 to 70 of about 2,725 (177)

Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study

BMC Medical Genetics, 2010
Background In addition to smoking, genetic predisposition is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Dezso Balazs, Scholtz Beata, Csanky Eszter, Poliska Szilard, Penyige Andras, Schmelczer Ivan, Kilty Iain, Takacs Laszlo, Nagy Laszlo   +8 more
doaj   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

BMC Cancer, 2006
Background Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is
Gao Weimin, Hu Xu, Wang Shaokang, Xie Yin, Tang Yuntian, Sun Guiju, Tang Lili, Wang Zemin, Cox Stephen B, Wang Jia-Sheng   +9 more
doaj   +1 more source

Structure and organization of the microsomal xenobiotic epoxide hydrolase gene.

Journal of Biological Chemistry, 1987
The gene for the microsomal xenobiotic rat liver epoxide hydrolase has been isolated and characterized. Clones were obtained from a Wistar Furth Charon 35 genomic library by hybridization with a full-length epoxide hydrolase cDNA. The gene for the xenobiotic epoxide hydrolase is approximately 16 kilobases in length and consists of 9 exons ranging in ...
Charles B. Kasper, Charles N. Falany, P McQuiddy   +2 more
openaire   +3 more sources

Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 5, Page 620-640, November 2024.
Abstract Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. As perinatal asphyxia and TH impact neonatal physiology, this could also influence enzyme functionality. Therefore, this study aimed to unravel the impact of age, hypothermia and hypoxia on porcine hepatic cytochrome P450 (CYP) gene expression ...
Marina‐Stefania Stroe, Laura De Clerck, Maarten Dhaenens, Rachel Siân Dennis, Dieter Deforce, Sebastien Carpentier, Pieter Annaert, Karen Leys, Anne Smits, Karel Allegaert, Chris Van Ginneken, Steven Van Cruchten   +11 more
wiley   +1 more source

PharmVar GeneFocus: CYP4F2

Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 963-975, October 2024.
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain ...
Pablo Zubiaur, Cristina Rodríguez‐Antona, Erin C. Boone, Ann K. Daly, Evangelia Eirini Tsermpini, Lubna Q. Khasawneh, Katrin Sangkuhl, Jorge Duconge, Mariana R. Botton, Jessica Savieo, Charity Nofziger, Michelle Whirl‐Carrillo, Teri E. Klein, Andrea Gaedigk   +13 more
wiley   +1 more source

COVID‐19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples

British Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2137-2158, September 2024.
Aim Understanding how COVID‐19 impacts the expression of clinically relevant drug metabolizing enzymes and membrane transporters (DMETs) is vital for addressing potential safety and efficacy concerns related to systemic and peripheral drug concentrations.
Chukwunonso K. Nwabufo, Jessica Luc, Allison McGeer, Jeremy Alexander Hirota, Samira Mubareka, Andrew C. Doxey, Theo J. Moraes   +6 more
wiley   +1 more source

Association of functional variants of phase I and II genes with chronic obstructive pulmonary disease in a Serbian population [PDF]

Journal of Medical Biochemistry, 2015
Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by increased oxidative stress. Functional genetic variants of phase I and II genes are implicated in oxidants-antioxidants imbalance and may be involved in COPD ...
Stanković Marija, Nikolić Aleksandra, Tomović Andrija, Mitić-Milikić Marija, Nagorni-Obradović Ljudmila, Petrović-Stanojević Nataša, Radojković Dragica   +6 more
doaj  

Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals [PDF]

Toxicological Sciences, 1999
Inhibition of xenobiotic-metabolizing enzymes by metals may represent an important mechanism in regulating enzyme activity. Fourteen cations were evaluated for inhibition of microsomal epoxide hydrolase (mEH) (mouse, rat, and human liver), soluble epoxide hydrolase (sEH) (mouse, rat, and human liver), and recombinant potato sEH.
Bruce D. Hammock, Alison J. Draper
openaire   +3 more sources

Characterizing the Nonlinear Pharmacokinetics and Pharmacodynamics of BI 187004, an 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Humans by a Target‐Mediated Drug Disposition Model

The Journal of Clinical Pharmacology, Volume 64, Issue 8, Page 993-1005, August 2024.
Abstract BI 187004, a selective small‐molecule inhibitor of 11β‐hydroxysteroid dehydrogenase‐1 (11β‐HSD1), displayed complex nonlinear pharmacokinetics (PK) in humans. Following nine single oral doses, BI 187004 exhibited nonlinear PK at low doses and linear PK at higher doses.
Xuanzhen Yuan, Guohua An
wiley   +1 more source