Results 71 to 80 of about 6,917 (192)

Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. [PDF]

, 2007
BACKGROUND: The distribution and the potential gene-gene and gene-environment interaction of selected metabolic genetic polymorphisms was investigated in relation to gastric cancer risk in an Italian population.
Arzani D, Boccia S, D'Ugo D, Gianfagna F, La Greca A, La Torre G, Persiani R, Rausei S, Ricciardi G, Sayed-Tabatabaei FA, van Duijn CM   +10 more
core   +1 more source

Expression of Human Microsomal Epoxide Hydrolase in Saccharomyces cerevisiae Reveals a Functional Role in Aflatoxin B1 Detoxification [PDF]

, 2017
The metabolism and genotoxicity of the carcinogenic mycotoxin, aflatoxin B1 (AFB), was studied in the lower eukaryotic yeast Saccharomyces cerevisiae. Recombinant strains of yeast were engineered to express human cDNAs for CYP1A1, CYP1A2, and microsomal ...
Eaton, David L., Erickson, Kristin E., Kelly, Edward J., Sengstag, Christian   +3 more
core  

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.

PLoS ONE, 2012
BackgroundMicrosomal epoxide hydrolase (EPHX1) plays an important role in both the activation and detoxification of PAHs, which are carcinogens found in cooked meat and tobacco smoking.
Fei Liu, Ding Yuan, Yonggang Wei, Wentao Wang, Lvnan Yan, Tianfu Wen, Mingqing Xu, Jiayin Yang, Bo Li   +8 more
doaj   +1 more source

Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin‐D2 in fiber type determination during myogenesis

The FASEB Journal, Volume 38, Issue 24, 31 December 2024.
Transcriptomics (bulk and single‐nuclei RNAseq) and lipidomics (mass spectrometry) analysis showed that slow‐twitch muscle (soleus) is enriched in bioactive lipids derived from docosahexaenoic acid (DHA) and their biosynthesizing enzymes compared to fast‐twitch muscle (tibialis anterior).
Lupann Rieger, Thomas Molina, Paul Fabre, Karine Greffard, Ornella Pellerito, Junio Dort, Jean‐François Bilodeau, Nicolas A. Dumont   +7 more
wiley   +1 more source

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice [PDF]

, 2015
The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the
Albrecht Seidel, Annette M. Krais, David H. Phillips, Ewoud N. Speksnijder, Frederik-J. van Schooten, Heinz H. Schmeiser, Joost P. M. Melis, Klaus Kopka, Marie Stiborova, Michaela Moserova, Mirjam Luijten, Radek Indra, Roger W. Godschalk, Volker M. Arlt   +13 more
core   +3 more sources

Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study

BMC Medical Genetics, 2010
Background In addition to smoking, genetic predisposition is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Dezso Balazs, Scholtz Beata, Csanky Eszter, Poliska Szilard, Penyige Andras, Schmelczer Ivan, Kilty Iain, Takacs Laszlo, Nagy Laszlo   +8 more
doaj   +1 more source

The moulting arthropod: a complete genetic toolkit review

Biological Reviews, Volume 99, Issue 6, Page 2338-2375, December 2024.
ABSTRACT Exoskeletons are a defining character of all arthropods that provide physical support for their segmented bodies and appendages as well as protection from the environment and predation. This ubiquitous yet evolutionarily variable feature has been instrumental in facilitating the adoption of a variety of lifestyles and the exploitation of ...
Giulia Campli, Olga Volovych, Kenneth Kim, Werner P. Veldsman, Harriet B. Drage, Idan Sheizaf, Sinéad Lynch, Ariel D. Chipman, Allison C. Daley, Marc Robinson‐Rechavi, Robert M. Waterhouse   +10 more
wiley   +1 more source

Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

BMC Cancer, 2006
Background Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is
Gao Weimin, Hu Xu, Wang Shaokang, Xie Yin, Tang Yuntian, Sun Guiju, Tang Lili, Wang Zemin, Cox Stephen B, Wang Jia-Sheng   +9 more
doaj   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

The genetics of chronic obstructive pulmonary disease. [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction.
Lomas, DA, Silverman, EK
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