Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +2 more
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Microsomes are the in vitro ER
The Journal of Cell Biology, 2005 ![Graphic][1] Microsomes (here) and ER look similar, and both have ribosomes (see dots near “ob2”). PALADEThe abundance of electron microscope (EM) images in the 1940s and 1950s brought a new problem: nomenclature. What to call all those black smudges?
openaire +3 more sources
ChemMedChem, Accepted Article.We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi +3 more
wiley +1 more source
Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II1The sequence reported in this paper has been deposited in the DDBJ, GenBank and EMBL databases (CYP93B1, accession No. AB001380).1 [PDF]
The microsome of insect cells expressing CYP Ge-5 (CYP93B1), a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), catalyzed the formation of [14C]licodione and [14C]-2-hydroxynaringenin from (2S)-[14C]liquiritigenin and (2S)-[14C]naringenin ...
Akashi, Tomoyoshi +2 more
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Clinical Pharmacology &Therapeutics, EarlyView.Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann +6 more
wiley +1 more source
THADA regulates the organismal balance between energy storage and heat production [PDF]
, 2017 Human susceptibility to obesity is mainly genetic, yet the underlying evolutionary drivers causing variation from person to person are not clear. One theory rationalizes that populations that have adapted to warmer climates have reduced their metabolic ...
Braeckman, Bart +10 more
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Iron concentrations in neurons and glial cells with estimates on ferritin concentrations
, 2019 BACKGROUND: Brain iron is an essential as well as a toxic redox active element. Physiological levels are not uniform among the different cell types. Besides the availability of quantitative methods, the knowledge about the brain iron lags behind. Thereby,
Arendt, T. +4 more
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Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). [PDF]
, 2017 Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins
Tian, Li, Wu, Sheng
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Drug Testing and Analysis, EarlyView.The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler +4 more
wiley +1 more source
The Effects Of Selected Pesticides On Cytochrome P450 System And Acetylcholinesterase Activity In Haruan, Channa Striatus [PDF]
, 2000 Sebaran Sitokrom P-4S0 mikrosomal dikesan dalam organ haruan (Channa striatus), ikan air tawar tropika. Pengasingan mikrosom telah dilakukan berdasarkan tiga kaedah iaitu pengemparan-ultra pada 105,000 g selama 60 minit, pengemparan kelajuan-tinggi ...
Yu, Tian
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