Results 121 to 130 of about 11,599 (234)

Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors. [PDF]

ACS Med Chem Lett
Li S, Yang X, Yin W, Zhang W, Li Z, Hu J, Li Y.   +6 more
europepmc   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Editorial: Non-invasive methods in drug metabolism and transport: insights from biological samples to oral administration. [PDF]

Front Pharmacol
Wróblewski K, Zheng Y, Yue X.
europepmc   +1 more source

AlphaFold‐driven discovery of oxysterol‐binding protein‐related protein‐phosphoinositide 3‐, 4‐, and 5‐phosphatase interactions using new generation confidence scores

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Non‐vesicular lipid transport contributes to the regulation of membrane composition and organelle function at membrane contact sites. OSBP‐related proteins (ORPs) are central to this process, yet their interaction networks remain incompletely defined. Here, we systematically screened potential interactions between ORPs and phosphoinositide 3‐,
Filippo Dall'Armellina, Sylvie Urbé, Daniel J. Rigden   +2 more
wiley   +1 more source

Association of peripheral natural killer cell percentage with age, body mass index, serum anti- Müllerian hormone, various autoantibodies, and thrombophilia-related markers in women undergoing in vitro fertilization. [PDF]

Clin Exp Reprod Med
Choi H, Jee BC.
europepmc   +1 more source

Machine Learning Meets Pharmacokinetics: A Comparative Analysis of Predictive Models for Plasma Concentration‐Time Profiles

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predicting pharmacokinetic (PK) profiles from molecular structures represents a significant advancement in pharmaceutical research with substantial implications for expediting drug discovery processes. We evaluated five approaches to systematically compare five distinct methodological frameworks for predicting rat plasma concentration‐time ...
Felix Jost, Clemens Giegerich, Christoph Grebner, Hans Matter, Henrik Cordes   +4 more
wiley   +1 more source

A perspective review on factors that influence mutagenicity in medicinal plants and their health implications. [PDF]

Toxicol Sci
Fasiku V, Kyagaba D, Hlalele A, Adegoke A, Erukainure OL, Sekhoacha M.   +5 more
europepmc   +1 more source

Population Pharmacokinetics and Exposure‐Response Analysis of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Ziftomenib, a potent, highly selective, oral menin inhibitor, has demonstrated significant clinical benefit and deep responses in relapsed and/or refractory (R/R) nucleophosmin 1‐mutated (NPM1‐m) acute myeloid leukemia (AML) patients. Here we present data from analyses conducted to characterize ziftomenib pharmacokinetics (PK) in healthy ...
Amitava Mitra, Xiaoyan Yang, Roberto H. Ortiz, Claudia Jomphe, Mollie Leoni, Nathalie H. Gosselin   +5 more
wiley   +1 more source

Network Analysis Identifies Microsomal Glutathione S‐Transferase as a Potential Regulator of Oxidative Stress and Proteasome Dysfunction in Human Osteoarthritic Menisci

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Schematic diagram of the study design. OA = osteoarthritis, GSE = Genomic Spatial Event database, DEG = Differentially expressed genes, WGCNA = Weighted gene co‐expression network analysis, MCC = Maximal clique centrality. ABSTRACT Osteoarthritis (OA)‐related meniscal degeneration involves complex interactions between oxidative stress and proteasomal ...
Xinjie Wu, Amina Hamzatova, Cecilia Aulin, Wei Sun, Andre Struglics, David A. Hart, Paul W. Ackermann, Aisha S. Ahmed   +7 more
wiley   +1 more source

Rough microsomes isolated from snap-frozen canine pancreatic tissue retain their co-translational translocation functionality. [PDF]

Biol Methods Protoc
Croonenborghs M, Verhaegen M, Pauwels E, Provinciael B, Vermeire K.   +4 more
europepmc   +1 more source