Results 141 to 150 of about 11,599 (234)

In-silico assessment of phytochemical derivatives generated using CHEESE webserver for advancement of druggable candidate in pancreatic cancer therapy. [PDF]

In Silico Pharmacol
Olowosoke CB, Ishabiyi FO, Bouribab A, Munir A, Awoyemi B, Nsofo WN, Christabel AC, Joy JO, Chtita S, Omoboyede V, Chukwuemeka PO.   +10 more
europepmc   +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long, Franz‐Josef Meyer‐Almes, Aleksandra Kopranovic, Stephen P. Wren   +3 more
wiley   +1 more source

Evaluating diagnostic efficacy of multigene testing in non-diagnostic thyroid nodules by fine-needle aspiration cytology: A prospective cohort study. [PDF]

Chin J Cancer Res
Zhang G, Ren L, Xiao J, Bao Y, Tian H, Shi Q, Tang C, Chen P, Liang Y, Tang P, Yan W, Zhang Y, Qi X, Guo Y, Zhang Y.   +14 more
europepmc   +1 more source

Precise subcellular organelle-targeted analyses of hepatotoxicity of <i>Polygonum multiflorum</i>. [PDF]

Chin Herb Med
Li Y, Duan S, Zhang Y, Liu R, Sun R, Wu J, Ma Z, Li X.   +7 more
europepmc   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Thiadiazino-indole, thiadiazino-carbazole and benzothiadiazino-carbazole dioxides: synthesis, physicochemical and early ADME characterization of representatives of new tri-, tetra- and pentacyclic ring systems and their intermediates. [PDF]

Beilstein J Org Chem
Pusztai G, Poszávácz L, Vincze A, Marton A, Abdulhussein AQ, Halász J, Dancsó A, Simig G, Balogh GT, Volk B.   +9 more
europepmc   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6-epi-β-Verbesinol Coumarate and Its In Silico Prediction of the Toxicity. [PDF]

Chem Biodivers
Vencato SB, Borsoi G, Feistel C, Charão MF, Joaquim AR, Picada JN, Ferraz ABF.   +6 more
europepmc   +1 more source

Structural basis of regulated N-glycosylation at the secretory translocon. [PDF]

Nature
Yamsek M, Ma M, Jha R, Wan Y, Li Q, Zhong F, DeLong K, Ji Z, Rohatgi R, Keenan RJ.   +9 more
europepmc   +1 more source

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo. [PDF]

J Med Chem
Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR.   +18 more
europepmc   +1 more source