Results 111 to 120 of about 32,983 (314)

Human phase‐I metabolism of three synthetic cannabinoids bearing a cumyl moiety and a cyclobutyl methyl or norbornyl methyl tail: Cumyl‐CBMEGACLONE, Cumyl‐NBMEGACLONE, and Cumyl‐NBMINACA

Drug Testing and Analysis, EarlyView.
The human phase‐I metabolism of three SCRAs bearing a cumyl moiety and a CBM or NBM tail, based on LC‐qToF‐MS data of authentic urine specimens. Abstract Synthetic cannabinoid receptor agonists (SCRAs) continue to show high prevalence on the new psychoactive substances drug market.
Arianna Giorgetti, Pietro Brunetti, Belal Haschimi, Benedikt Pulver, Jennifer Paola Pascali, Jan Riedel, Volker Auwärter   +6 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

ER Microsome Preparation and Subsequent IAA Quantification in Maize Coleoptile and Primary Root Tissue

Bio-Protocol, 2016
Auxin is a major growth hormone in plants and the first plant hormone to be discovered and studied (Darwin and Darwin, 1880). The auxin molecule in plants was first identified as indole-3-acetic acid (IAA) by Kögl et al. (1934).
Verena Kriechbaumer
doaj   +1 more source

Gel Electrophoretic Detection of Black Market ACE‐031

Drug Testing and Analysis, EarlyView.
This article presents a study on black market ACE‐031 products and their detection by gel‐electrophoresis and Western blotting. Of the 14 tested products, only 12 contained an ACVR2B‐immunoreactive protein. However, mass spectrometry revealed that the products did not contain the ACVR2B‐Fc fusion protein ACE‐031 but instead the full‐length human ...
Christian Reichel, Thomas Filip, Günter Gmeiner, Mario Thevis   +3 more
wiley   +1 more source

A comparison of the prevalence of anti-Liver/Kidney Microsome antibody type-1(LKM-1) in individuals with chronic hepatitis C and those with autoimmune hepatitis

مجلة كلية الطب, 2007
Background: Autoantibodies are frequently found in patients with chronic hepatitis C, which suggests that HCV elicit an immune response in the host. ).
Eman Sh. AL- Obeidy, Nahida R. Abbs, Aida R. AL-Derzi   +2 more
doaj  

The Oxidation of TPNH by Rat Liver Microsomes and its Stimulation by Inducing Agents. [PDF]

, 1959
Alexandra von der Decken, T. Hultin, Carl Axel Wachtmeister, Susanne Refn   +3 more
openalex   +1 more source

Giant number fluctuations in microbial ecologies

, 2012
Statistical fluctuations in population sizes of microbes may be quite large depending on the nature of their underlying stochastic dynamics. For example, the variance of the population size of a microbe undergoing a pure birth process with unlimited ...
Das, Dibyendu, Das, Dipjyoti, Prasad, Ashok   +2 more
core   +1 more source

Metabolic Identification Based on Proposed Mass Fragmentation Pathways of the Anabolic Steroid Bolasterone by Gas Chromatography Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
The metabolism of bolasterone in liver microsomes and in urine samples of rats orally treated was evaluated due to no availability of its extensive metabolism studies. Its mono‐ and di‐hydroxylated metabolites were detected by GC‐EI‐MS/MS, and the fragmentation pathways of metabolites were suggested.
Anca Raluca Muresan, Khandoker Asiqur Rahaman, Farzana Binte Rafique, Junghyun Son, Min‐Jung Kang, Oh‐Seung Kwon   +5 more
wiley   +1 more source

Analyzing the topology of N-linked glycans by PNGase F accessibility assay

STAR Protocols, 2023
Summary: While N-glycans are synthesized in the lumens, some of them reach the cytosolic side of membranes through retro-translocation independent of endoplasmic-reticulum-associated degradation.
Jingcheng Wang, Jin Ye
doaj