Results 121 to 130 of about 63,135 (311)

Systemic exposure and bioavailability of delgocitinib cream in adults with moderate to severe Chronic Hand Eczema

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Delgocitinib cream demonstrated minimal systemic exposure and no significant accumulation over time in patients with moderate to severe CHE. The systemic exposure was significantly lower versus oral administration (relative bioavailability: 0.6%). These findings suggest that no systemic pharmacological effect is expected with topical application of ...
Diamant Thaçi   +5 more
wiley   +1 more source

Processing of rat liver apoprotein E primary translation product.

open access: yesJournal of Lipid Research, 1984
The primary translation product of rat liver apoE mRNA was isolated from wheat germ cell-free translation systems. Plasma apoE and the primary translation product migrated similarly on SDS-polyacrylamide gels, had similar partial proteolytic peptide maps,
C A Reardon   +3 more
doaj  

A Microsomal Nucleoside Diphosphatase

open access: yesJournal of Biological Chemistry, 1963
Margareta Heus, Alex B. Novikoff
openaire   +3 more sources

Compositional and Metabolomic Shifts of the Gut Microbiome in Alcohol‐Related Liver Disease

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Alcohol‐related liver disease (ALD) is a major global health concern characterized by steatosis and liver inflammation due to chronic alcohol consumption. Emerging evidence suggests that ALD is not solely a liver pathology but also involves dysfunction of the gut‐liver axis, where alterations in the gut microbiota play a significant role ...
Cheng‐Hao Kuo   +4 more
wiley   +1 more source

The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun   +5 more
wiley   +1 more source

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

open access: yesScientific Reports
Solid transplant recipients are at increased risk for invasive aspergillosis. Tacrolimus and Voriconazole is one of the most frequently utilized treatments for those recipients with invasive fungal infections.
Yi-Chang Zhao   +10 more
doaj   +1 more source

7α-Hydroxylation of cholestanol by rat liver microsomes

open access: hybrid, 1968
Sarah Shefer   +2 more
openalex   +1 more source

Home - About - Disclaimer - Privacy