Results 121 to 130 of about 74,782 (341)

Factors influencing the incorporation of amino acid into the protein of microsome and mitochondria preparations of rat liver and liver tumour [PDF]

, 1959
Olga Greengard, P.N. Campbell
openalex   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid [PDF]

, 1959
Luc E. Gosselin, G. Popják
openalex   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, EarlyView.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Some chemical components of mitochondria and microsomes from germinating castor beans [PDF]

, 1957
Takashi Akazawa, Harry Beevers
openalex   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

The Mutagenic Potential of Chloroform, Orange Oil, Eucalyptus Oil and Halothane by Salmonella/Microsome Assay [PDF]

, 2004
Svrha rada bila je ispitati mutagenu aktivnost četiriju komercijalno dostupnih otapala gutaperke Salmonella/mikrosomskim testom. Ispitana su bila otopala: kloroform, narančino ulje, eukaliptusovo ulje i halotan u količinama od 10 μl, 30 μl, 50 μl, 100 μl
Ivana Miletić, Ivica Anić, Maja Osmak, Silvana Jukić, Smiljana Britvić, Zoran Karlović   +5 more
core   +1 more source

The Oxidation of TPNH by Rat Liver Microsomes and its Stimulation by Inducing Agents. [PDF]

, 1959
Alexandra von der Decken, T. Hultin, Carl Axel Wachtmeister, Susanne Refn   +3 more
openalex   +1 more source

Chemical profiling and characterisation of anthraquinone‐based polyphenols as biocolourants from Cortinarius semisanguineus

Coloration Technology, EarlyView.
Abstract Anthraquinone dyes are known for their significant colour (brightness of shade in the red, blue and green areas) and light fastness properties compared with other synthetic dyes (such as azo‐based dyes). However, challenging multi‐step synthesis of anthraquinones and limited access to fewer substituents result in insufficient reactivity ...
Arvind Negi, Peppi Toukola, Riikka Räisänen   +2 more
wiley   +1 more source

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source