Results 141 to 150 of about 32,983 (314)

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

Neurobiology of Disease, 2018
α-synuclein (αS) is a small protein that self-aggregates into α-helical oligomer species and subsequently into larger insoluble amyloid fibrils that accumulate in intraneuronal inclusions during the development of Parkinson's disease.
Emanuela Colla, Giulia Panattoni, Alessio Ricci, Caterina Rizzi, Lucia Rota, Nicola Carucci, Verdiana Valvano, Francesco Gobbo, Simona Capsoni, Michael K. Lee, Antonino Cattaneo   +10 more
doaj  

Effects of vitamins A and D on the biosynthesis of l-ascorbic acid by rat-liver microsomes [PDF]

, 1965
NC GHOSH, I. B. Chatterjee, GC Chatterjee   +2 more
openalex   +1 more source

Studies on phospholipids. 8. Phospholipids in rat-liver mitochondria and microsomes [PDF]

, 1961
F. D. Collins, Valerie L. Shotlander
openalex   +1 more source

Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke, Lahiru Wedasingha, Magnus Rydberg   +2 more
wiley   +1 more source

Tissue‐Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency

PROTEOMICS, EarlyView.
ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo, Jeremie Zander Lindeque, Marianne Venter   +2 more
wiley   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Journal of Lipid Research, 2000
Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-{N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino}-1,1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and ...
Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Issei Ohtsuka, Ichiro Yoshida, Takao Saeki, Hiroshi Tanaka   +6 more
doaj  

Middle‐Out Physiologically Based Pharmacokinetic Modeling to Support Pediatric Dosing Recommendation for Alectinib

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Adult patients with anaplastic lymphoma kinase positive (ALK+) advanced non–small‐cell lung cancer (NSCLC) are treated with 600 mg alectinib twice daily (BID) as first‐line treatment. ALK positive solid and central nervous system (CNS) tumors are described in the pediatric population, with limited clinical data due to the rarity of the disease
Tamara van Donge, Elena Guerini, Amaury O'Jeanson, Neil Parrott, Clare Devlin, Cordula Stillhart, Nassim Djebli   +6 more
wiley   +1 more source

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen   +12 more
wiley   +1 more source

A Hemochromogen Component of Liver Microsomes

, 1952
Cornelius F. Strittmatter, Eric G. Ball
openalex   +1 more source