Results 61 to 70 of about 22,884 (277)
Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism
Pharmaceutical Biology, 2019 Context: Paeoniflorin is reported to possess numerous pharmacological activities. Paeoniflorin and glycyrrhizin are always used together for the treatment of disease in China clinics; however, the drug–drug interaction between glycyrrhizin and ...
Hongjuan Sun, Jingfeng Wang, Juan Lv
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ChemMedChem, EarlyView.The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi +3 more
wiley +1 more source
Effects of psoralen on the pharmacokinetics of anastrozole in rats
Pharmaceutical Biology, 2018 Context: Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. Objective: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. Materials and
Yuzhu Zhang +4 more
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Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative
Molecules, 2017 Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields.
Liang-Chieh Chen +4 more
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ChemMedChem, EarlyView.Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann +6 more
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Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Microsomal epoxide hydrolase polymorphisms
Molecular Medicine Reports, 2010 Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively.
Pinarbasi, Hatice +2 more
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Drug Testing and Analysis, EarlyView.Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer +13 more
wiley +1 more source
Microsomes are the in vitro ER
The Journal of Cell Biology, 2005 ![Graphic][1] Microsomes (here) and ER look similar, and both have ribosomes (see dots near “ob2”). PALADEThe abundance of electron microscope (EM) images in the 1940s and 1950s brought a new problem: nomenclature. What to call all those black smudges?
openaire +3 more sources