Results 71 to 80 of about 32,983 (314)
Smooth microsomes. a trap for cholesteryl ester formed in hepatic microsomes.
Journal of Biological Chemistry, 1980 Acyl-CoA:cholesterol acyltransferase was found predominantly (85%) in RNA-rich microsomes, the rest being in RNA-poor and smooth microsomes. However, the esterified cholesterol concentration of smooth microsomes was 2-fold greater than that of RNA-rich microsomes, suggesting the possibility of an interaction between RNA-rich and smooth microsomes.
S Hashimoto, A M Fogelman
openaire +3 more sources
ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT
Journal of Lipid Research, 2003 Microsomal acyl CoA:cholesterol acyltransferase (AC57) is stimulated in vitro and/or in intact cells by proteins that bind and transfer both substrates, cholesterol, and fatty acyl CoA.
Hsu Chao +4 more
doaj
Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs
Brazilian Journal of Medical and Biological Research, 2004 The GLUT4 transporter plays a key role in insulin-induced glucose uptake, which is impaired in insulin resistance. The objective of the present study was to investigate the tissue content and the subcellular distribution of GLUT4 protein in 4- to 12-year-
A.M. Vargas +5 more
doaj +1 more source
Journal of Lipid Research, 2007 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial ω-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E.
Timothy J. Sontag, Robert S. Parker
doaj
Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells [PDF]
Archives of Biological Sciences, 2005 The inhibition of spontaneous and UV-induced mutations by essential oil (EO) of sage (Salvia officinalis L.) and its fractions F1-F5 containing different proportions of mono- and sesquiterpenes was studied with the Salmonella/microsome, E.
Knežević-Vukčević Jelena B. +5 more
doaj +1 more source
Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism
Pharmaceutical Biology, 2018 Context: Asiatic acid has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.
Ling Guo, Ying Cui, Kaijun Hao
doaj +1 more source
Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells [PDF]
, 2006 Apicularen A and the known vacuolar-type (H+)-ATPase (V-ATPase) inhibitor bafilomycin A1 induced apoptosis of RAW 264.7 cells, while apicularen B, an N-acetyl-glucosamine glycoside of apicularen A, was far less effective.
Ahn, Jong-Woong +11 more
core +1 more source
Frontiers in Oncology, 2022 It is well known that the role of gut microbiota in drug metabolism, especially in oral difficult absorbable drugs. Understanding the gut microbiota could enable us to understand drugs in new ways.
Adili Keranmu +7 more
doaj +1 more source
PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response [PDF]
, 2012 Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage
A Bertolotti +29 more
core +1 more source
Cancer Communications, EarlyView.Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao +12 more
wiley +1 more source