Results 71 to 80 of about 50,037 (190)

Tissue-specific uptake and distribution of liquid crystal monomers (LCMs) in mice

Environment International, 2023
Increasing evidence indicated that liquid crystal monomers (LCMs) in liquid crystal displays can be released into the environment, and ubiquitously detected in environmental matrices and even human bodies.
Yi Kong, Yong Wen, Guanyong Su, Ying Peng, Xinyi Cui   +4 more
doaj  

Pretraining Graph Transformers with Atom-in-a-Molecule Quantum Properties for Improved ADMET Modeling [PDF]

arXiv
We evaluate the impact of pretraining Graph Transformer architectures on atom-level quantum-mechanical features for the modeling of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of drug-like compounds. We compare this pretraining strategy with two others: one based on molecular quantum properties (specifically the ...
arxiv  

Transformers for molecular property prediction: Domain adaptation efficiently improves performance [PDF]

arXiv
Most of the current transformer-based chemical language models are pre-trained on millions to billions of molecules. However, the improvement from such scaling in dataset size is not confidently linked to improved molecular property prediction. The aim of this study is to investigate and overcome some of the limitations of transformer models in ...
arxiv  

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

Neurobiology of Disease, 2018
α-synuclein (αS) is a small protein that self-aggregates into α-helical oligomer species and subsequently into larger insoluble amyloid fibrils that accumulate in intraneuronal inclusions during the development of Parkinson's disease.
Emanuela Colla, Giulia Panattoni, Alessio Ricci, Caterina Rizzi, Lucia Rota, Nicola Carucci, Verdiana Valvano, Francesco Gobbo, Simona Capsoni, Michael K. Lee, Antonino Cattaneo   +10 more
doaj  

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Journal of Lipid Research, 2000
Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-{N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino}-1,1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and ...
Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Issei Ohtsuka, Ichiro Yoshida, Takao Saeki, Hiroshi Tanaka   +6 more
doaj  

A Microsomal Nucleoside Diphosphatase

Journal of Biological Chemistry, 1963
Margareta Heus, Alex B. Novikoff
openaire   +3 more sources

Microsomal enzymes in malnutrition. [PDF]

BMJ, 1977
I T Gilmore, R P Thompson
openaire   +3 more sources

Processing of rat liver apoprotein E primary translation product.

Journal of Lipid Research, 1984
The primary translation product of rat liver apoE mRNA was isolated from wheat germ cell-free translation systems. Plasma apoE and the primary translation product migrated similarly on SDS-polyacrylamide gels, had similar partial proteolytic peptide maps,
C A Reardon, R V Hay, J I Gordon, G S Getz   +3 more
doaj  

Microsomal Enzyme Induction [PDF]

Toxicological Sciences, 2000
openaire   +3 more sources

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes. [PDF]

Nat Struct Mol Biol
Pyle E, Miller EA, Zanetti G.
europepmc   +2 more sources