Results 71 to 80 of about 22,884 (277)

Gel Electrophoretic Detection of Black Market ACE‐031

Drug Testing and Analysis, EarlyView.
This article presents a study on black market ACE‐031 products and their detection by gel‐electrophoresis and Western blotting. Of the 14 tested products, only 12 contained an ACVR2B‐immunoreactive protein. However, mass spectrometry revealed that the products did not contain the ACVR2B‐Fc fusion protein ACE‐031 but instead the full‐length human ...
Christian Reichel, Thomas Filip, Günter Gmeiner, Mario Thevis   +3 more
wiley   +1 more source

Metabolic Identification Based on Proposed Mass Fragmentation Pathways of the Anabolic Steroid Bolasterone by Gas Chromatography Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
The metabolism of bolasterone in liver microsomes and in urine samples of rats orally treated was evaluated due to no availability of its extensive metabolism studies. Its mono‐ and di‐hydroxylated metabolites were detected by GC‐EI‐MS/MS, and the fragmentation pathways of metabolites were suggested.
Anca Raluca Muresan, Khandoker Asiqur Rahaman, Farzana Binte Rafique, Junghyun Son, Min‐Jung Kang, Oh‐Seung Kwon   +5 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy

Epilepsia Open, EarlyView.
Abstract Objective Carbamazepine is the first line treatment for patients affected by KCNQ2 developmental and epileptic encephalopathy. It is efficient to reduce or stop seizures in this context. However, its effect on the neurodevelopmental outcomes is debated.
Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard   +7 more
wiley   +1 more source

ER Microsome Preparation and Subsequent IAA Quantification in Maize Coleoptile and Primary Root Tissue

Bio-Protocol, 2016
Auxin is a major growth hormone in plants and the first plant hormone to be discovered and studied (Darwin and Darwin, 1880). The auxin molecule in plants was first identified as indole-3-acetic acid (IAA) by Kögl et al. (1934).
Verena Kriechbaumer
doaj   +1 more source

A comparison of the prevalence of anti-Liver/Kidney Microsome antibody type-1(LKM-1) in individuals with chronic hepatitis C and those with autoimmune hepatitis

مجلة كلية الطب, 2007
Background: Autoantibodies are frequently found in patients with chronic hepatitis C, which suggests that HCV elicit an immune response in the host. ).
Eman Sh. AL- Obeidy, Nahida R. Abbs, Aida R. AL-Derzi   +2 more
doaj  

Analyzing the topology of N-linked glycans by PNGase F accessibility assay

STAR Protocols, 2023
Summary: While N-glycans are synthesized in the lumens, some of them reach the cytosolic side of membranes through retro-translocation independent of endoplasmic-reticulum-associated degradation.
Jingcheng Wang, Jin Ye
doaj  

The Oxidation of TPNH by Rat Liver Microsomes and its Stimulation by Inducing Agents. [PDF]

, 1959
Alexandra von der Decken, T. Hultin, Carl Axel Wachtmeister, Susanne Refn   +3 more
openalex   +1 more source

Toxicological Response of the BEAS‐2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m‐Xylene Alone and in Binary Mixtures

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzene, toluene, ethylbenzene, and xylenes (o‐, m‐, and p‐xylenes) constitute a family, named BTEX, of volatile organic compounds (VOCs) known for its toxicity. This study aimed to study the acute in vitro toxicity of ethylbenzene and m‐xylene on human bronchial epithelial cells exposed at the air–liquid interface (ALI).
Nour Jaber, Claude Emond, Fabrice Cazier, Sylvain Billet   +3 more
wiley   +1 more source

Antimutagenic activity of cashew apple (Anacardium occidentale Sapindales, Anacardiaceae) fresh juice and processed juice (cajuína) against methyl methanesulfonate, 4-nitroquinoline N-oxide and benzo[a]pyrene

Genetics and Molecular Biology, 2008
Cashew apple juice (CAJ), produced from the native Brazilian cashew tree (Anacardium occidentale), and has been reported to have antibacterial, antifungal, antitumor, antioxidant and antimutagenic properties.
Ana Amelia Melo-Cavalcante, Jaqueline N. Picada, Gabriel Rubensam, João A.P. Henriques   +3 more
doaj   +1 more source