Results 271 to 280 of about 1,677,689 (317)

A microsomal endoribonuclease from rat liver

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
An endoribonuclease has been purified about 320-fold from the microsomes of rat liver. The enzyme had an apparent molecular weight of 54 000-58 000 and produced oligonucleotides, each consisting of 3-7 nucleotides from poly(A) and poly(U). No mononucleotide was obtained by the enzymatic hydrolysis of poly(A) and poly(U) under standard coditions.
Seiyu Hirose, Kazuei Igarashi, Takemi Takayama, Kaori Watanabe, Hiroshi Kumagai, Kazue Sugimoto   +5 more
openaire   +2 more sources

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.

Chemical Research in Toxicology, 1993
Acetaminophen (APAP), a commonly used analgesic, is catalyzed by cytochrome P450 (P450) enzymes to a toxic intermediate which can be trapped by glutathione.
C. Patten, P. Thomas, R. Guy, Mao-Jun Lee, F. J. Gonzalez, F. Guengerich, C. Yang   +6 more
semanticscholar   +1 more source

Development of Liver Microsomal Oxidations in the Chick

Xenobiotica, 1976
1. Liver microsomal preparations from chick embryos (1 day before hatching) and from 1-7 day old chicks were assayed for oxidative drug-metabolizing activity with aminopyrine, aniline and naphthalene as substrates. 2. Activities for all three substrates were highest in preparations from 1 day-old chicks.
W. R. Jondorf, D. E. Macintyre, A. H. Drummond, Garth Powis   +3 more
openaire   +3 more sources

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.

Carcinogenesis, 1992
An acetyltransferase-overexpressing strain of Salmonella typhimurium (NM2009) has been used to investigate roles of human liver microsomal cytochrome P450 (P450) enzymes in the activation of carcinogenic nitrosamine derivatives, including N ...
H. Yamazaki, Y. Inui, C. Yun, F. Guengerich, T. Shimada   +4 more
semanticscholar   +1 more source

Metabolism of naphthalene by pigeon liver microsomes

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979
Abstract 1. Microsomal mixed-function oxidase of the pigeon liver shows maximum activity and stability at 44°C and 6.8 pH. Naphthalene is metabolized to 1-naphthol and 1,2-diol and a number of minor metabolites. The MFO activity and P-450 contents of pigeon liver microsomes, under optimum conditions show about 1 3 to 1 4 activity of ...
M.A.Q. Khan, J.C. Grossman
openaire   +3 more sources

THE MECHANISM OF SCHRADAN ACTIVATION BY LIVER MICROSOMES

Canadian Journal of Biochemistry and Physiology, 1957
The mechanism by which schradan is converted to a powerful anticholinesterase by fortified liver homogenates has been studied. A scheme is proposed involving the production from DPNH of hydrogen peroxide, which then oxidizes an unknown microsomal factor with the aid of catalase. The factor in turn oxidizes schradan.
openaire   +3 more sources

Ethylene Formation in Rat Liver Microsomes

Science, 1966
Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
Paul Hochstein, Morris Lieberman
openaire   +3 more sources

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

Biochemistry, 1990
Three cDNAs, designated IIA3, IIA3v, and IIA4, coding for P450s in the CYP2A gene subfamily were isolated from a lambda gt11 library prepared from human hepatic mRNA.
S. Yamano, Jun Tatsuno, F. J. Gonzalez
semanticscholar   +1 more source

Biotransformation of N-ethyl perfluorooctanesulfonamide by rainbow trout (Onchorhynchus mykiss) liver microsomes.

Environmental Science and Technology, 2004
Rainbow trout (Onchorhynchus mykiss) liver microsomes were incubated with N-ethyl perfluorooctanesulfonamide [N-EtPFOSA, C8F17SO2NH(C2H5)], to examine the possibility of in vitro biotransformation to perfluorooctane sulfonate (PFOS, C8F17SO3-) and ...
G. Tomy, S. Tittlemier, V. Palace, Wes R. Budakowski, Eric Braekevelt, Lyndon Brinkworth, K. Friesen   +6 more
semanticscholar   +1 more source

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.

Archives of Biochemistry and Biophysics, 1997
Roles of human cytochrome P450 (P450 or CYP) 2C9, 2C19, and 3A4 in the oxidation of progesterone and testosterone were studied in recombinant P450 enzymes and in human liver microsomes.
H. Yamazaki, T. Shimada
semanticscholar   +1 more source