Results 111 to 120 of about 56,066 (278)
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine ChanSu with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core
Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes
, 1987 1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. Covalent binding of [14C] 1,1-DCE to isolated lung and liver microsomes from CD-1 mice required NADPH and was strongly inhibited by carbon monoxide.
P. G. Forkert, W. J. Racz, M. Hofley
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo +10 more
wiley +1 more source
Comparative Metabolism of Cinobuafgin in Liver Microsomes from Mouse,Rat,Dog,Pig,Monkey and Human
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine Chan-Su with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core
A hepatic enigma: Pediatric presentation of primary biliary cholangitis
JPGN Reports, EarlyView.Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune condition characterized by destruction of intrahepatic bile ducts, leading to fibrosis and cirrhosis of the liver. It is an extremely rare pediatric disease with very few pediatric cases reported to date. Here, we report the case of a 14‐year‐old female who presented with elevated liver
Sindhura Kasturi +3 more
wiley +1 more source
In Vitro Metabolic Study of Boc5 in human tissues and Animal Liver Microsomes
, 2009 As the first nonpeptidic agonist of glucagon-like peptide 1 receptor, Boc5 can invoke sustained glycemic control and weight loss in diabetic C57BL/6J mice, and has become a promising hit compound for antidiabetic drug. Boc5 displays good efficiency via i.
梁思成 +4 more
core
rflaA:Ova is differently processed in mDC-derived microsomes.
, 2014 Microsomes were isolated from unstimulated BALB/c mDC and used for digestion of rOva and rflaA:Ova (A+B). Protein amounts equimolar to 5 µg rOva (5 µg rOva, 8.5 µg rflaA:Ova) were digested for each indicated time point.
Masako Toda (587290) +15 more
core +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Characterization Of In Vitro Metabolism of Brucine Using Human Liver Microsomes
, 2010 Background. Brucine, one of the bitter alkaloids isolated from Chinese folk medicine Strychnos nux-vomica L. (Loganiaceae), is known as an effective analgesic and anti- inflammatory agent for relieving arthritic and traumatic pain.
房中则 +4 more
core
Preparation of brain microsomes with cytochrome P450 activity using calcium aggregation method
, 1990 Microsomes have been conventionally prepared by centrifugation of the postmitochondrial supernatant at 100,000g using an ultracentrifuge. Liver microsomes have been prepared by low speed centrifugation following sedimentation of the microsomal membranes ...
Anandatheerthavarada, Hindupur K. +1 more
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