Results 131 to 140 of about 49,138 (216)

Development and Validation of an LC-MS/MS Method for the Quantitation of JNJ-64619178 (JNJ) in Mouse Plasma: Characterization of In Vitro and In Vivo Pharmacokinetic Properties. [PDF]

Molecules
Ahmed N, Kshirsagar P, Ding L, Murry DJ, Chaturvedi NK, Chhonker YS.   +5 more
europepmc   +1 more source

Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids. [PDF]

Pharmaceutics
Song IS, Pang M, Lee MS, Lee J, Liu KH, Choi MK, Park HJ, Kim H, Lee HS.   +8 more
europepmc   +1 more source

<i>In Vitro</i> Liver Models for Studying Pharmaceutical Metabolism in Fish - A Critical Analysis of Their Applications and Limitations. [PDF]

Environ Sci Technol
Matthee C, Pihlaja TLM, Järvinen P, Brown AR, Lange A, Sikanen TM, Tyler CR.   +6 more
europepmc   +1 more source

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and <i>in Vivo</i> in Mice. [PDF]

ACS Med Chem Lett
Simon KT, Hailemariam SE, Friedman E, Wen YW, Freaney M, Barker-Haliski M, Isoherranen N.   +6 more
europepmc   +1 more source

Discovery of <i>N</i>-Acetyltransferase 8-Like (NAT8L) inhibitors based on a <i>N</i>-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold. [PDF]

ACS Med Chem Lett
Nayeen MJ, Thomas AG, Kundu B, Carlyle E, Hin N, Hin P, Pal A, Paule J, Rais R, Slusher BS, Tsukamoto T.   +10 more
europepmc   +1 more source

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery. [PDF]

Proc Natl Acad Sci U S A
Davey SD, Forde-Thomas JE, Hulme BJ, Lees K, Costain AH, Evans M, Rinaldi G, Frame L, Stojanovski L, Simeons FRC, Tavendale A, MacLeod AK, Pichon R, Lee YH, Polak O, Chalmers IW, Dankwa B, Odhiambo BK, Guimaraes VH, Hegarty M, Swain MT, Aubrey W, Caldwell N, MacDonald AS, Gilbert IH, Baragaña B, Read KD, Hoffmann KF.   +27 more
europepmc   +1 more source

Fine-Tuning a Transformer Model for METTL3 Lead Optimization. [PDF]

ACS Bio Med Chem Au
Matter CM, Caflisch A.
europepmc   +1 more source

QSAR-ME Profiler 2025: A New Software for QSA(P)R Predictions Supported by Structural Analysis. [PDF]

Chem Res Toxicol
Chirico N, Sgariboldi A, Evangelista M, Papa E.   +3 more
europepmc   +1 more source

Development of highly potent EP2 antagonists as novel anti-inflammatory neuroprotectants. [PDF]

Bioorg Med Chem
Jiang C, Cho EB, Jin Z, Bahraminejad S, Ma D, Yu Y, Liu J, Jiang J.   +7 more
europepmc   +1 more source

Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies. [PDF]

ACS Med Chem Lett
Bouton J, Bretteville A, Tresadern G, Shaffer P, Austin N, Buijnsters P, Cedervall EP, Darville N, Fonteyn I, Leenaerts J, Lamenca CM, Mertens L, Peeters D, Velter AI, Roosbroeck YV, Ebneth A, Bartolomé JM, Trabanco AA, Oehlrich D.   +18 more
europepmc   +1 more source