Results 151 to 160 of about 49,138 (216)

Prediction of human exposure and first-pass metabolism of the fungicide trifloxystrobin using an in vitro intestinal pancreatin and Caco-2/HT29-MTX model. [PDF]

Arch Toxicol
Hallscheidt E, Bothe K, Hahn M, Hartmann K, Thevis M, Lamshoeft M.   +5 more
europepmc   +1 more source

Humanization of Drug Metabolism in the <i>Plasmodium berghei</i> Mouse Model for Antimalarial Drug Discovery. [PDF]

ACS Infect Dis
MacLeod AK, Merino C, Viera-Morilla S, Frame L, Tavendale A, Duncan C, Ferguson L, Pinto EG, Simeons FRC, Gomez-Jimenez V, García AB, Riley J, Shishikura Y, Martínez-Martínez MS, Wolf CR, Read KD.   +15 more
europepmc   +1 more source

Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs. [PDF]

Drug Metab Dispos
Shimizu M, Nii A, Uno Y, Yamazaki H.
europepmc   +1 more source

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats. [PDF]

Drug Des Devel Ther
Xie C, Guan T, Huang J, Chen J, Li Y, Zheng P.   +5 more
europepmc   +1 more source

Aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole attenuates pressure overload cardiac hypertrophy by activating the CYP1A1/19(S)-hydroxyeicosatetraenoic acid (HETE) and suppressing midchain-HETEs/G protein coupled receptor 31 pathways. [PDF]

Drug Metab Dispos
Alammari AH, Hamza SM, Isse FA, Gopal K, Ussher JR, El-Kadi AOS.   +5 more
europepmc   +1 more source

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The preparation of microsomes

Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie, 1965
Various methods of disrupting liver cells and preparing microsomes were studied. The quality and yield of the microsomes in the preparations was judged by the NADPH-dependent N- and p-hydroxylation of N-ethylaniline, protein content, and cyanide-sensitive respiration.
R, von Jagow, H, Kampffmeyer, M, Kiese
openaire   +2 more sources

Microsomal Proteomics

2009
Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
openaire   +2 more sources

Fusion of microsomal vesicles

Experientia, 1978
Studies which indicate the fusion of rat liver microsomal vesicles show that the rate of fusion of microsomal vesicles, as revealed by electron microscopic examinations, is dependent on the fusion temperature and the amount of detergent present in the microsomal suspension.
H U, Schulze, L, Pop
openaire   +2 more sources

Microsomal metabolism of fluoroanilines

Xenobiotica, 1989
1. The microsomal, cytochrome P-450-dependent metabolism of fluoroanilines was studied using 19F-n.m.r. and also by a chemical assay for the hydroxy derivatives. 2. 2-Fluoro- and 3-fluoroaniline were preferentially hydroxylated at the para-position. 3. 4-Fluoroaniline was both p- and o-hydroxylated to a significant extent. 4.
Rietjens, I.M.C.M., Vervoort, J.
openaire   +3 more sources