Results 141 to 150 of about 49,138 (216)

The novel third-generation antipsychotic drug brexpiprazole affects hepatic transcription factors, serum hormone levels, and cytochrome P450 enzymes after prolonged treatment: pharmacological significance. [PDF]

Pharmacol Rep
Danek PJ, Pukło R, Daniel WA.
europepmc   +1 more source

Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy. [PDF]

Blood Adv
Shen G, Song D, Li S, Chen X, Richter CE, Dong S, Guo Y, Liu H, Shen Y, Hao Z, Stafford DW, Shavit JA, Cao Q, Tie JK.   +13 more
europepmc   +1 more source

Effect of Cytochrome P450 2C9 genetic polymorphism on agomelatine metabolism <i>in vitro</i>. [PDF]

PeerJ
Fang P, Ni J, Shen T, Chen Q, Ye X, Jin J, Dai D, Hu G, Qian J, Cai J, Chen L.   +10 more
europepmc   +1 more source

Evaluation of Pyrrole Heterocyclic Derivatives as Selective MAO-B Inhibitors and Neuroprotectors. [PDF]

Molecules
Georgieva M, Sharkov M, Mateev E, Mateeva A, Kondeva-Burdina M.   +4 more
europepmc   +1 more source

Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. [PDF]

J Med Chem
Valderrama K, Horlacher O, Publicola G, Eisenring P, Kienle M, Boarbi S, Kiass M, Korduláková J, Chatagnon J, Piveteau C, Leroux F, Savková K, Záhorszká M, Cantrelle FX, Lherbet C, Mourey L, Mikušová K, Mathys V, Aichholz R, Maveyraud L, Altmann KH, Hartkoorn RC.   +21 more
europepmc   +1 more source

Metabolism of the Isoflavone Derivative Structural Isomers ACF-02 and ACF-03 in Human Liver Microsomes. [PDF]

Pharmaceutics
Liang Z, Kim EH, Kim GY, Choi JH, Seo HJ, Liu KH, Cho M.   +6 more
europepmc   +1 more source

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent. [PDF]

Front Pharmacol
Wang R, Jin Y, Zou B, Ding L.
europepmc   +1 more source

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively. [PDF]

Pharmaceuticals (Basel)
Grangeon A, Arwood ML, Thacker D, Gaudette F, Turgeon J, Michaud V.   +5 more
europepmc   +1 more source

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics. [PDF]

ACS Pharmacol Transl Sci
Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T, Faibille AB, Bourn LA, Ramdhan PA, Ricchezza J, Jordan S, Panasis D, Nguyen N, Kasarla N, Wang B, Garcia SS, Saez J, Paule J, Lee CB, Rais R, Slusher BS, Sibley DR, Li C, Keck TM, Boateng CA.   +24 more
europepmc   +1 more source

Eukaryotic cell-free protein synthesis: Chassis diversification, system engineering, and emerging applications. [PDF]

Synth Syst Biotechnol
Tong S, Wang Y, Wang X, Jin X, Tan D, Wang Z, Lu Y.   +6 more
europepmc   +1 more source