Results 121 to 130 of about 49,138 (216)

Structure-Based Drug Discovery of Non-SAM-Mimetic Bisubstrate Inhibitors against Nicotinamide <i>N</i>‑Methyltransferase. [PDF]

ACS Med Chem Lett
Yoshida S, Kondo N, Uehara S, Yoshimura N, Sako Y, Yamamoto S, Kitade M, Tachibana Y.   +7 more
europepmc   +1 more source

Combining <i>in vivo</i> and <i>in vitro</i> studies to elucidate the inhibitory effect of resveratrol on vorolanib metabolism. [PDF]

Front Pharmacol
Chen D, Xia H, Cao L, Fu H, Chen Y, Jiang S, Zhan R.   +6 more
europepmc   +1 more source

In Vitro Cytochrome P450 Interaction Profile and ADME Characterisation of Gold(I)-Triphenylphosphine Complexes with 6-Alkoxy-9-deazapurine Ligands. [PDF]

Pharmaceutics
Medvedíková M, Vančo J, Trávníček Z, Anzenbacher P.   +3 more
europepmc   +1 more source

Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies. [PDF]

Cell Biol Toxicol
Wang P, Fu H, Wu J, Li R, Cao L, Xu RA, Lin W.   +6 more
europepmc   +1 more source

Optimized UPLC-MS/MS Method for the Simultaneous Quantification of Pazopanib and GSK-1268997 and Its Application to Drug-Drug Interaction Studies. [PDF]

Drug Des Devel Ther
Cao L, Wang P, Li R, Fu H, Wu J, Xia H, Xie S, Zeng C.   +7 more
europepmc   +1 more source

Pharmacokinetics, distribution, metabolism, excretion and safety characterization of ZJCK-6-72: novel DYRK1A inhibitor with optimized brain exposure for Alzheimer's disease therapy. [PDF]

Front Pharmacol
Li Z, Chen H, Li X, Yang A, Wang X, Liu S, Ning X, Zhou L, Zheng F, Xun F, Hu B, Cui Y, Yao D, Gao X, Xu Z, Zhao Q.   +15 more
europepmc   +1 more source

Early ADME and Preliminary Toxicity Studies of I-152, an <i>N</i>-Acetyl-l-Cysteine/<i>S</i>-Acetylcysteamine Conjugate. [PDF]

Chem Res Toxicol
Bartoccini F, Valeri A, Gregori M, Masini S, Bruschi M, Goracci L, Fraternale A, Piersanti G.   +7 more
europepmc   +1 more source

In vitro thyroperoxidase inhibition assessment by LC-ICP-MS-based L-tyrosine iodination assay: comparison with Amplex Ultrared assay and its modifications. [PDF]

Arch Toxicol
Liu R, Novák J, Kuta J, Smutná M, Hilscherová K.   +4 more
europepmc   +1 more source

Epoxidation of cyclodiene compounds by rat liver microsomes

Rat liver microsomes are shown to contain an enzyme system which converts the cyclodiene insecticides, aldrin, heptachlor and isodrin to their corresponding epoxides, dieldrin, heptachlor epoxide, and endrin.
Wong, David Taiwai
core  

Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii. [PDF]

BMC Genomics
Muhammad A, Ibrahim SS, Ismail HM, Irving H, Paine MJI, Wondji CS.   +5 more
europepmc   +1 more source