Results 171 to 180 of about 56,066 (278)

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan, Oliver Krug, Gregor Fußhöller, Thomas Piper, Mario Thevis   +4 more
wiley   +1 more source

In vitro formation kinetics of two 2,5-dimethylfuran phase-I metabolites: cis-3-hexene-2,5-dione and 5-methylfurfuryl alcohol. [PDF]

Arch Toxicol
Appel J, Kulosa C, Becker N, Stegmüller S, Sadzik S, Richling E.   +5 more
europepmc   +1 more source

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

Effects of Normothermic Hepatic Ischemia-Reperfusion Injury on the Hepatic Disposition of Arachidonic Acid and Its Cytochrome P450-Generated Metabolites in Rats. [PDF]

Pharm Res
Edpuganti V, Mehvar R.
europepmc   +1 more source

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Influenza A virus modulates host innate immune pathways, including TLR, RIG‐I, MAPK, and NF‐κB signaling, to support replication and drive inflammatory pathology. Plant‐derived phytocompounds target these interconnected pathways, offering a potential host‐directed immunomodulatory approach complementary to conventional antivirals.
Dibakar Chowdhury, Hillary A. Vanderven, Phurpa Wangchuk, Subir Sarker   +3 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis. [PDF]

Angew Chem Int Ed Engl
Okunlola GA, Aleku GA.
europepmc   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Discovery of Novel Small-Molecule Toll-like Receptor 2 Agonists via a Scaffold Hopping Strategy. [PDF]

ACS Med Chem Lett
Zhu Y, Wang L, Chen Y, Wang Y, Chen Z, Li Y, Zhang W.   +6 more
europepmc   +1 more source

Development, Early Verification and Application of a North American Pediatric PBPK Model, Comparison With the North European Pediatric Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) models are increasingly used in pediatric drug development and matching such models to the target population is an important consideration. A US pediatric PBPK model was developed incorporating four sub‐groups describing physiology and enzymatic/transporter levels for White, African American ...
Trevor N. Johnson, Fiskani Kondowe, Joyce van der Heijden, Saskia N. de Wildt, Iain Gardner, Karen Rowland Yeo   +5 more
wiley   +1 more source

Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis. [PDF]

Chembiochem
Dhiman S, Manhas D, Jamwal A, Singh A, Kumar V, Vij B, Ojha PK, Singh SK, Ahmed Z, Nandi U.   +9 more
europepmc   +1 more source