Results 181 to 190 of about 96,126 (327)

AlphaFold‐driven discovery of oxysterol‐binding protein‐related protein‐phosphoinositide 3‐, 4‐, and 5‐phosphatase interactions using new generation confidence scores

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Non‐vesicular lipid transport contributes to the regulation of membrane composition and organelle function at membrane contact sites. OSBP‐related proteins (ORPs) are central to this process, yet their interaction networks remain incompletely defined. Here, we systematically screened potential interactions between ORPs and phosphoinositide 3‐,
Filippo Dall'Armellina, Sylvie Urbé, Daniel J. Rigden   +2 more
wiley   +1 more source

Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid [PDF]

, 1959
Luc E. Gosselin, G. Popják
openalex   +1 more source

Machine Learning Meets Pharmacokinetics: A Comparative Analysis of Predictive Models for Plasma Concentration‐Time Profiles

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predicting pharmacokinetic (PK) profiles from molecular structures represents a significant advancement in pharmaceutical research with substantial implications for expediting drug discovery processes. We evaluated five approaches to systematically compare five distinct methodological frameworks for predicting rat plasma concentration‐time ...
Felix Jost, Clemens Giegerich, Christoph Grebner, Hans Matter, Henrik Cordes   +4 more
wiley   +1 more source

Reductive dominance and limited cytochrome P450 activity in neonicotinoid metabolism by elephant liver microsomes. [PDF]

J Vet Med Sci
Watanabe K, Khidkhan K, Saengtienchai A, Somgrid C, Towiboon P, Angkawanish T, Langkaphin W, Namwongprom K, Kittisirik N, Yohannes YB, Ikenaka Y, Nakayama SM, Ishizuka M.   +12 more
europepmc   +1 more source

Population Pharmacokinetics and Exposure‐Response Analysis of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Ziftomenib, a potent, highly selective, oral menin inhibitor, has demonstrated significant clinical benefit and deep responses in relapsed and/or refractory (R/R) nucleophosmin 1‐mutated (NPM1‐m) acute myeloid leukemia (AML) patients. Here we present data from analyses conducted to characterize ziftomenib pharmacokinetics (PK) in healthy ...
Amitava Mitra, Xiaoyan Yang, Roberto H. Ortiz, Claudia Jomphe, Mollie Leoni, Nathalie H. Gosselin   +5 more
wiley   +1 more source

Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism. [PDF]

Sci Rep
Kinatukara N, Xu X, Shah P.
europepmc   +1 more source

The participation of sterol carrier protein2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes.

, 1981
K.L. Gavey, B.J. Noland, T J Scallen
openalex   +1 more source

Network Analysis Identifies Microsomal Glutathione S‐Transferase as a Potential Regulator of Oxidative Stress and Proteasome Dysfunction in Human Osteoarthritic Menisci

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Schematic diagram of the study design. OA = osteoarthritis, GSE = Genomic Spatial Event database, DEG = Differentially expressed genes, WGCNA = Weighted gene co‐expression network analysis, MCC = Maximal clique centrality. ABSTRACT Osteoarthritis (OA)‐related meniscal degeneration involves complex interactions between oxidative stress and proteasomal ...
Xinjie Wu, Amina Hamzatova, Cecilia Aulin, Wei Sun, Andre Struglics, David A. Hart, Paul W. Ackermann, Aisha S. Ahmed   +7 more
wiley   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Unraveling Cannabidiol's Bidirectional Regulation of Melatonin Pharmacokinetics via PEPT1/CYP1A2: Mechanistic Insights and Quantitative Projections. [PDF]

Pharmaceuticals (Basel)
Zheng B, Wang M, Zhang Q, Li C, Wang L, Zhang W, Liu C, Zhuang X.   +7 more
europepmc   +1 more source