Results 181 to 190 of about 56,066 (278)

Thiazolidine‐2,4‐dione and Thiazole Derivatives as Privileged Structures for Dengue Virus: A Review of Medicinal Chemistry Aspects

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
This graphical abstract summarizes thiazole, thiazolidine‐2,4‐dione, and hybrid compounds investigated as antiviral candidates against dengue virus. Representative structures and reported potencies are presented in the context of DENV serotypes. Proposed molecular targets include NS2B–NS3 protease and NS5.
Pedro César de Souza, Thaynara Paula Warren Bezerra, Matheus Vinicius Guimarães de Melo, Thayná da Silva Barros, Matheus Italo da Conceição, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo   +6 more
wiley   +1 more source

Design of aptamer peptides for immunomodulation. [PDF]

J Enzyme Inhib Med Chem
Chowdhury A, Shrestha P, Subramanian V, Mayandi V, Mahajan M, Jois SD.   +5 more
europepmc   +1 more source

A Fusion Between Common Bean Phaseolin and the N‐Terminal Domain of Maize 16 kDa Gamma Zein: Clues for Designing Nutritionally Improved Seed Storage Proteins

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5408-5424, October 2026.
ABSTRACT Increasing the nutritional value of seed storage proteins (SSPs) has been largely hindered by limited knowledge of how the features of the various SSP domains determine high accumulation in protein storage vacuoles (PSV) or as endoplasmic reticulum (ER)‐located insoluble protein bodies (PB).
Emma Costa, Lucrezia Luciani, Mahsa Taghipour Rahimi, Alessandro Vitale, Emanuela Pedrazzini   +4 more
wiley   +1 more source

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing. [PDF]

PLoS One
Meng Q, Wang X, Zhang Y, Pushpakom S, Yang J, Feng H, Wang M.   +6 more
europepmc   +1 more source

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, Volume 111, Issue 10, Page 4457-4497, 1 October 2026.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

Crocetin Halts Tumorigenesis in Metastatic Breast Cancer via Disrupting CYP2J2/EET Axis. [PDF]

ACS Omega
Manhas D, Jamwal A, Kaur G, Akhter MQ, Arora N, Kumar V, Ojha PK, Sawant SD, Bag S, Goswami A, Nandi U.   +10 more
europepmc   +1 more source

Expression of Active Apurinic Apyrimidinic Endodeoxyribonuclease 1 in Human Platelets

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Platelets (PLTs) isolated from healthy donors contain variable amounts of enzymatically active APE1, likely surveilling mitochondrial DNA integrity and overall mitochondria functioning. The use of the specific APE1 inhibitor compound #3 on platelet rich plasma (PRP) significantly impairs the PLTs' aggregation properties of activated PLTs triggered only
Isabella Parolini, Alessia Bellina, Giada Carpi, Evgeniia A. Diatlova, Giovanna Lippe, Elisabetta Fontanini, Giovanni Barillari, Miriam Isola, Antonio P. Beltrami, Gianluca Tell   +9 more
wiley   +1 more source

Age (juvenile to aged) and sex effects on in vitro CYP2A6 enzyme activity in African green monkeys using nicotine and coumarin. [PDF]

Drug Metab Dispos
Gu W, Tyndale RF.
europepmc   +1 more source

Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Ro 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Carlos Cruz‐Cortés, Jaroslava Šeflová, Guadalupe Guerrero‐Serna, Eric N. Jimenez‐Vazquez, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +5 more
wiley   +1 more source

Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications. [PDF]

Sci Rep
Lee MS, Song IS, Jang Y, Cho YY, Lee JY, Kang HC, Kim JH, Lee HS.   +7 more
europepmc   +1 more source