Results 151 to 160 of about 81,174 (219)

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions. [PDF]

Sci Rep
Zhao YC, Zhang YK, Gao W, Liu HY, Xiao CL, Hou JJ, Li JK, Zhang BK, Xiang DX, Sandaradura I, Yan M.   +10 more
europepmc   +1 more source

Noninvasive Evaluation of Prolonged‐Release Pirfenidone in Compensated Liver Cirrhosis. ODISEA Study, a Randomised Trial

Liver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background Advanced liver fibrosis (ALF) predicts an adverse prognosis in chronic liver disease. In addition to etiological treatment, a new approach to stop or reverse residual fibrosis is desirable. Objective To assess the efficacy and safety of prolonged‐release pirfenidone (PR‐PFD) versus placebo in compensated cirrhosis.
Linda E. Muñoz‐Espinosa, Aldo Torre, Laura Cisneros, Iaarah Montalvo, René Malé, Scherezada Mejía, Juan Ramón Aguilar, Javier Lizardi, Jaime Zuñiga‐Noriega, María Eugenia Icaza, Frida Gasca‐Díaz, Larissa Hernández‐Hernández, Paula Cordero‐Pérez, Luis Chi, Lilian Torres, Fátima Rodríguez‐Alvarez, Graciela Tapia, Jorge Luis Poo   +17 more
wiley   +1 more source

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia. [PDF]

RSC Chem Biol
Kasai T, Fujita K, Komatsu T, Ueno T, Kojima R, Hanaoka K, Urano Y.   +6 more
europepmc   +1 more source

Divergent Genetic Pathways Underlying Convergent Parasitic Behaviours in Blowflies

Molecular Ecology, Volume 34, Issue 11, June 2025.
ABSTRACT Blowfly (Diptera: Calliphoridae) exhibit diverse feeding strategies, with most species developing on decomposing organic matter. However, parasitism has evolved within the family, and some species convergently gained the ability to explore the tissues of living vertebrate hosts, which imposes critical veterinary, medical, and agricultural ...
Gisele Antoniazzi Cardoso, Pedro Mariano‐Martins, Gustavo Amaral Faria, Inoka Karunaratne, Patricia Jacqueline Thyssen, Tatiana Teixeira Torres   +5 more
wiley   +1 more source

Biochemical characterization of the human ubiquitous glucose-6-phosphatase in neutrophil granulocytes. [PDF]

FEBS Open Bio
Lédeczi Z, Németh K, Kardon T.
europepmc   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1988-2005, June 2025.
Schematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Basanta Lamichhane, Sarah‐Eve Gélinas, Natacha Merindol, Manoj Koirala, Karen Cristine Gonçalves dos Santos, Hugo Germain, Isabel Desgagné‐Penix   +6 more
wiley   +1 more source

Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling. [PDF]

J Pharm Anal
He Y, Zhu C, Lei P, Yang C, Zhang Y, Zheng Y, Diao X.   +6 more
europepmc   +1 more source

LY354740, an agonist of glutamatergic metabotropic receptor mGlu_2/3 increases the cytochrome P450 2D (CYP2D) activity in the frontal cortical area of rat brain. [PDF]

Pharmacol Rep
Bromek E, Haduch A, Pukło R, Daniel WA.
europepmc   +1 more source

Flavonoids and Saponins from Two <i>Chenopodium</i> Species (<i>C. foliosum</i> Asch. and <i>C. bonus</i>-<i>henricus</i> L.)-Preliminary Evaluation for hMAO-A/B, Neuroprotective Activity, and Validated UHPLC-HRMS Quantification of Ethanolic Extract from <i>C. foliosum</i>. [PDF]

Molecules
Kondeva-Burdina M, Panayotova D, Nedialkov PT, Kokanova-Nedialkova Z.   +3 more
europepmc   +1 more source