Results 261 to 270 of about 129,619 (377)

1-methylnicotinamide modulates IL-10 secretion and voriconazole metabolism. [PDF]

Front Immunol
Deng X, Li Y, Jiang L, Xie X, Wang X.
europepmc   +1 more source

The influence of severe hepatic dysfunction on the metabolic capacity of the liver in children : composition and characterization of a liver tissue bank [PDF]

, 2011
Boussery, K, De Bock, L, De Paepe, Peter, Sokal, E, Stephenne, X, Van Bocxlaer, J, Van Winckel, Myriam   +6 more
core   +1 more source

Lack of Chronic Morphine Effect on the Induction of Drug-Metabolizing Enzymes of Liver Microsomes by Phenobarbital in Female Rats.

, 1967
Ryuichi Kato, Akira Takanaka
openalex   +2 more sources

Prostaglandin E Receptor 2 (EP2) Dysregulation in Allergic Fungal Rhinosinusitis Nasal Polyp Epithelium

The Laryngoscope, Volume 135, Issue S1, Page S1-S8, April 2025.
This work represents the first report of dysregulated prostaglandin receptor synthesis in allergic fungal rhinosinusitis (AFRS). In an unbiased analysis of all genes expressed in AFRS versus healthy sinonasal epithelium at air–liquid interface, PTGER2 was the second most significantly upregulated gene. This finding was replicated by quantitative RT‐PCR
Prestina Smith‐Davidson, Khaled Altartoor, M.M. Kabongo, Henry Claussen, Robert A. Arthur, H.R. Johnston, John M. DelGaudio, Sarah K. Wise, C.A. Solares, Emily M. Barrow, Kelly R. Magliocca, Michael Koval, Joshua M. Levy   +12 more
wiley   +1 more source

Molecular Interactions of the Plant Steroid Hormone Epibrassinolide on Human Drug-Sensitive and Drug-Resistant Small-Cell Lung Carcinoma Cells. [PDF]

Cancers (Basel)
Sadava D, Chen S.
europepmc   +1 more source

Binding of Selected Ligands to Human Protein Disulfide Isomerase and Microsomal Triglyceride Transfer Protein Complex and the Associated Conformational Changes: A Computational Molecular Modelling Study

ChemistryOpen, Volume 14, Issue 4, April 2025.
The interactions of MTP, MTPα and MTPβ (PDI) with three representative small‐molecule ligands are investigated using computational structural and chemical analysis to characterize the binding site structures, the binding strength, the key residues involved, and the conformational changes.
Yong Xiao Yang, Peng Li, Bao Ting Zhu
wiley   +1 more source

ChatGPT does make up scientific references: should it be currently renamed CheatGPT? [PDF]

Eur J Clin Pharmacol
Mikus G.
europepmc   +1 more source

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics [PDF]

, 2017
Croubels, Siska, Deforce, Dieter, Devreese, Mathias, Gasthuys, Elke, Millecam, Joske, Van Bocxlaer, Jan   +5 more
core   +1 more source

Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss–Newton Method

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 770-780, April 2025.
ABSTRACT Grazoprevir (GZR), a direct‐acting agent for hepatitis C virus, is recognized as a substrate for organic anion transporting polypeptide 1B (OATP1B), cytochrome P450 3A (CYP3A), and P‐glycoprotein (P‐gp). The objective of the present study was to elucidate the contribution of these molecules to the nonlinear pharmacokinetics of GZR using a ...
Takashi Yoshikado, Yasunori Aoki, Ryo Nakamura, Saeko Shida, Yuichi Sugiyama, Koji Chiba   +5 more
wiley   +1 more source

Metabolic Activation of 2-Methylfuran to Acetylacrolein and Its Reactivity toward Cellular Proteins. [PDF]

Chem Res Toxicol
Schäfer V, Stegmüller S, Becker H, Richling E.   +3 more
europepmc   +1 more source