Results 321 to 330 of about 129,619 (377)
Some of the next articles are maybe not open access.
Microsomal metabolism of picene
Chemico-Biological Interactions, 1988Picene, a polycyclic aromatic hydrocarbon (PAH) of environmental relevance has recently been predicted to be carcinogenic, based on quantum mechanical calculation, although in several animal studies no carcinogenicity could be detected. In order to find out if the metabolism of this PAH can provide an explanation for its lack of carcinogenicity, picene
P. Petrovic +4 more
openaire +3 more sources
2009
Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
openaire +2 more sources
Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
openaire +2 more sources
Journal of Pharmacy and Science, 2011
Cytochrome P450 (CYP) proteins are involved in the biological oxidation and reduction of xenobiotics, affecting the pharmacological efficiency of drugs.
H. Kawakami +5 more
semanticscholar +1 more source
Cytochrome P450 (CYP) proteins are involved in the biological oxidation and reduction of xenobiotics, affecting the pharmacological efficiency of drugs.
H. Kawakami +5 more
semanticscholar +1 more source
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
Xenobiotica; the fate of foreign compounds in biological systems, 2009Acetaminophen is a widely used analgesic antipyretic agent. When used at low doses, it is a safe drug, but at higher doses it can cause acute hepatic necrosis in humans and experimental animals. The key mechanism in the hepatotoxicity is cytochrome P450 (
J. Laine +3 more
semanticscholar +2 more sources
Microsomal hydroxylation of decane
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969Abstract 1. 1. Aliphatic hydrocarbons (hexane, octane and decane) were oxidized in the microsomes from the livers of mouse, rat, rabbit, beef, pigeon and chick embryo. 2. 2. The oxidation of decane by mouse liver microsomes required NADPH and O 2 .
Kusunose Masamichi +2 more
openaire +3 more sources
Science, 1969
Deoxyribonucleic acid has been isolated from the microsomes of mouse liver homogenates under conditions designed to prevent or greatly reduce mitochondrial and nuclear contamination. The DNA rapidly incorporates tritiated thymidine, and this, together with its reannealing characteristics after thermal denaturation, shows that it is not mitochondrial or
Doris P. Courington +3 more
openaire +3 more sources
Deoxyribonucleic acid has been isolated from the microsomes of mouse liver homogenates under conditions designed to prevent or greatly reduce mitochondrial and nuclear contamination. The DNA rapidly incorporates tritiated thymidine, and this, together with its reannealing characteristics after thermal denaturation, shows that it is not mitochondrial or
Doris P. Courington +3 more
openaire +3 more sources
Lipid Peroxidation of Rat‐Liver Microsomes [PDF]
European Journal of Biochemistry, 1973 Rat liver microsomes were peroxidized in vitro and chemical, physical and morphological changes in the membrane were related to the effects on certain membrane‐bound microsomal enzymes.With increasing peroxidation, microsomal phospholipids revealed decreasing concentrations of 20:4 and 22:6 fatty acids.
Anders Bergstrand +2 more
openaire +2 more sources
Molecular Nutrition & Food Research, 2010
Glucuronidation constitutes an important pathway in the phase II metabolism of the mycotoxin zearalenone (ZEN) and the growth promotor α-zearalanol (α-ZAL, zeranol), but the enzymology of their formation is yet unknown.
E. Pfeiffer +3 more
semanticscholar +1 more source
Glucuronidation constitutes an important pathway in the phase II metabolism of the mycotoxin zearalenone (ZEN) and the growth promotor α-zearalanol (α-ZAL, zeranol), but the enzymology of their formation is yet unknown.
E. Pfeiffer +3 more
semanticscholar +1 more source
Drug Metabolism And Disposition, 2009
Species differences in the intrinsic clearance (CLint) and the enzymes involved in the metabolism of pyrethroid pesticides were examined in rat and human hepatic microsomes.
Edward J. Scollon +4 more
semanticscholar +1 more source
Species differences in the intrinsic clearance (CLint) and the enzymes involved in the metabolism of pyrethroid pesticides were examined in rat and human hepatic microsomes.
Edward J. Scollon +4 more
semanticscholar +1 more source
Chemical Research in Toxicology, 1993
Acetaminophen (APAP), a commonly used analgesic, is catalyzed by cytochrome P450 (P450) enzymes to a toxic intermediate which can be trapped by glutathione.
C. Patten +6 more
semanticscholar +1 more source
Acetaminophen (APAP), a commonly used analgesic, is catalyzed by cytochrome P450 (P450) enzymes to a toxic intermediate which can be trapped by glutathione.
C. Patten +6 more
semanticscholar +1 more source