Results 341 to 350 of about 129,619 (377)
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Drug Metabolism And Disposition, 2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported.
Y. Hijazi, R. Boulieu
semanticscholar +1 more source
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported.
Y. Hijazi, R. Boulieu
semanticscholar +1 more source
Non-Enzymic Lipid Peroxidation in Microsomes and Microsomal Phospholipids Induced by Anthracyclines
Free Radical Research Communications, 1986The stimulation of non-enzymic lipid peroxidation by doxorubicin, daunorubicin and 7 derivatives was investigated in extracted microsomal phospholipids and in intact microsomes. Evidence was obtained for the necessity of a free amino-sugar moiety for a stimulative effect on lipid peroxidation.
Jan Noordhoek +4 more
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Structure and chemistry of cytochrome P450.
Chemical Reviews, 2005Two decades have passed since the discovery in liver microsomes of a haemprotein that forms a reduced-CO complex with the absorptive maximum of the Soret at 450 nm (Klingenberg, 1958; Garfinkel, 1958) and the identification of this protein as a new ...
I. Denisov +3 more
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Microsomal Protein Mediates a pH-Dependent Fusion of Liposomes to Rat Brain Microsomes
Membrane Biochemistry, 1990The fusion between rat brain microsomes and liposomes is investigated by measuring the release of octadecylrhodamine B (R18) fluorescence self-quenching. In the experimental conditions used in this work, the method allows a rapid and quantitative evaluation of the mixing of microsome and liposome lipid phases.
PISTOLESI R +2 more
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The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.
Biochemistry, 1990Three cDNAs, designated IIA3, IIA3v, and IIA4, coding for P450s in the CYP2A gene subfamily were isolated from a lambda gt11 library prepared from human hepatic mRNA.
S. Yamano, Jun Tatsuno, F. J. Gonzalez
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Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding
Science, 1968Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ...
C. Lieber, L. Decarli
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The effect of deoxycholate on rat brain microsomes and microsomal (Na+K+)-ATPase
Brain Research, 1973Abstract Under carefully controlled conditions for the treatment of rat brain microsomal membranes with deoxycholate, a marked increase in the activities of (Na + K + )-ATPase and total ATPase were observed. The relationship between the increase in enzymic activities and the amount of protein rendered soluble could not explain the observed ...
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The formation of inorganic pyrophosphate in microsomes
Archives of Biochemistry and Biophysics, 1957Abstract The formation of inorganic pyrophosphate from orthophosphate in respiring liver homogenates has been investigated. The results indicate that the major source of the pyrophosphate-forming system is in the microsome fraction, and that the pyrophosphate is formed from ATP, which can be generated either oxidatively by mitochondria or ...
Sidney P. Colowick +2 more
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The stimulation of microsomal azoreduction by flavins
Biochimica et Biophysica Acta (BBA) - General Subjects, 1982The reduction of the azo dye, amaranth, by rat liver microsomes is inhibited about 90% by carbon monoxide, suggesting that the reaction largely depends on cytochrome P-450. Reducing equivalents for this reaction are supplied by NADPH. This reaction is stimulated by riboflavin, FMN and FAD, as well as by methylviologen.
Jack Peisach, Shoichi Fujita
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On the activation of microsomal UDPglucuronyltransferase by phospholipase A
Biochimica et Biophysica Acta (BBA) - Enzymology, 1974Abstract Activation of rat liver microsomal UDPglucuronyltransferase (EC 2.4.1.17) by phospholipase A (EC 3.1.1.4) was reversed by micellar dispersions of several phospholipids and by serum albumin. When microsomal membranes were treated with the phospholipase in presence of albumin, which binds and removes surface-active phospholipid degradation ...
Allan B. Graham, Geoffrey C. Wood
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