Results 141 to 150 of about 257,791 (336)

Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules

Neurology International
The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules.
Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Araki   +4 more
doaj   +1 more source

Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules

Ecotoxicology and Environmental Safety, 2021
Acute exposure to cadmium (Cd) causes vacuolar degeneration in buffalo rat liver 3 A (BRL 3 A) cells. The present study aimed to determine the relationship between Cd-induced microtubule damage and intracellular vacuolar degeneration.
Junzhao Yuan, Yumeng Zhao, Yuni Bai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Hui Zou, Jianchun Bian   +8 more
doaj  

Microtubule-associated proteins of HeLa cells: heat stability of the 200,000 mol wt HeLa MAPs and detection of the presence of MAP-2 in HeLa cell extracts and cycled microtubules. [PDF]

, 1982
J A Weatherbee, P Sherline, Renato N. Mascardo, Jonathan G. Izant, Ronald B. Luftig, Robert R. Weihing   +5 more
openalex   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

A novel microtubule-associated protein from mammalian nerve shows ATP-sensitive binding to microtubules. [PDF]

, 1986
Peter J. Hollenbeck, Kevin Chapman
openalex   +1 more source

Microtubule Organization and Microtubule-Associated Proteins (MAPs)

, 2016
Dendrites have a unique microtubule organization. In vertebrates, dendriticmicrotubules are organized in antiparallel bundles, oriented with their plusends either pointing away or toward the soma. The mixed microtubule arrayscontrol intracellular trafficking and local signaling pathways, and are essential fordendrite development and function.
Tortosa Binacua, E., Kapitein, L.C., Hoogenraad, C.C.   +2 more
openaire   +3 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2

Frontiers in Immunology
Aggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules.
Vadym Sulimenko, Vladimíra Sládková, Tetyana Sulimenko, Eduarda Dráberová, Věra Vosecká, Lubica Dráberová, Omar Skalli, Pavel Dráber   +7 more
doaj   +1 more source

A Supramolecular Material for Controlling Kiwifruit Bacterial Canker

Advanced Science, EarlyView.
The matrine‐5‐methylsalicylic acid salt (MOS) is reported for its excellent antibacterial activity against Pseudomonas syringae pv. actinidiae (Psa), with advanced cell membrane penetration ability and strong affinities for potential targets. Furthermore, a nanosupramolecular delivery system MOS@hydroxypropyl‐beta‐cyclodextrin (HPCD) with improved ...
Xile Deng, Qiang Bian, Mingqing Zhou, Le Xie, Jichuan Zhang, Tianqi Liu, Yizhuo Zhang, Li Zhang, Jiaheng Zhang, Lianyang Bai   +9 more
wiley   +1 more source

Model of ionic currents through microtubule nanopores and the lumen

, 2009
It has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its ...
A. M. Gomez, Avner Priel, D. K. Meyer, Eric Carpenter, Holly Freedman, J. A. Tuszynski, J. A. Tuszynski, Jack A. Tuszynski, Sergei Y. Noskov, V. A. Maltsev, Vahid Rezania   +10 more
core   +1 more source